Relationship between local and total bone mass in osteoporosis

Manzke, E; Chesnut, Charles H.; Wergedal, Jon E.; Baylink, David J.; Nelp, Wil B.

doi:10.1016/0026-0495(75)90140-7

Cited by 84 publications

(33 citation statements)

References 12 publications

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“…Figures 5a and 5b show the correlation of BMM with TBC. The normal men are given by the regression lines, the variation (SEE) is larger for this normal population than previously reported [20]. For the SI and S2 sites, the correlations (r = 0.484 and 0.455, respectively) are signifi cant (p<0.01).…”

Section: Pa Tien L Characteristicsmentioning

confidence: 82%

“…Measure ments were performed at SI and S2 (reprectively '/»> and Vs of the forearm length proximal to the styloid process) sites of the nondom inant arm (distal radius). The SI site has been shown to contain both cortical and trabecular bone, whereas S2 contains essentially corti cal bone [20], This technique has a precision of 2% and an accuracy of 4-7% [10], In a subsidiary study, BMM was determined in 39 normal, healthy men aged 21-96 years. These cross-sectional data form the basis for the regression line of BMM vs. age in normals reported here.…”

Section: Gamma Photon Ahsorbtiometrymentioning

confidence: 99%

“…Model 178, as previously described [20], In this technique, gamma photon absorption by a segment of bone is proportional to the mineral mass present in that segment. Measure ments were performed at SI and S2 (reprectively '/»> and Vs of the forearm length proximal to the styloid process) sites of the nondom inant arm (distal radius).…”

Section: Gamma Photon Ahsorbtiometrymentioning

confidence: 99%

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Calcium Balance in Uremia: Longitudinal Study of Long-Term Survivors

Schuster

Chesnut

Baylink

et al. 1985

Nephron

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Twelve male patients surviving uremia of 9–15 years duration were studied sequentially over a mean period of 9.2 years. Radiographs, bone biopsies, bone mineral mass (BMM) measured by photon absorptiometry, and total body calcium (TBC) determined by in vivo neutron activation analysis (NAA) were used. Pathologic fractures correlated with TBC corrected for height: 4 of 5 patients without fractures had TBC above 80% predicted, whereas 5 of 7 patients with fractures fell below this value. Unlike previous studies, negative calcium balance was seen in 3 patients with prolonged hyperparathyroidism. Though soft tissue calcification occurred in 6 patients, only 1 with massive shoulder calcification had an increase in TBC; this drawback of NAA has been previously overemphasized. Moreover, radial BMM also increased in 2 patients due to soft tissue calcification. When viewed at a single point in time, nearly all patients fell within the wide normal limits of BMM vs TBC. However, 6 patients with variable bone histology studied sequentially over a mean of 8.5 years showed significant preferential loss of radial bone mass compared to TBC. Aluminium retention did not influence calcium balance in these subjects.

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Section: Pa Tien L Characteristicsmentioning

confidence: 82%

Section: Gamma Photon Ahsorbtiometrymentioning

confidence: 99%

Section: Gamma Photon Ahsorbtiometrymentioning

confidence: 99%

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Calcium Balance in Uremia: Longitudinal Study of Long-Term Survivors

Schuster

Chesnut

Baylink

et al. 1985

Nephron

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“…Even at the distal radial site where trabecular bone makes up about 12% of the total bone [. Manzke et al, 1975], there is no increase in bone mineral content, as determined by photon absorptiometry.…”

Section: Clinical Findingsmentioning

confidence: 99%

Monofluorophosphate Physiology: The Effects of Fluoride on Bone

Baylink¹,

Duane²,

Farley³

et al. 1983

Caries Res

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Fluoride is an effective agent in the treatment of osteoporosis and is the only available agent that is capable of producing a large increment in bone mass. Fluoride stimulates bone formation largely through its action to increase osteoblast number. In vitro work suggests that the effect of fluoride to increase osteoblast number is due to a direct action of fluoride to stimulate the proliferation of osteoblast precursors. In fluoride-treated patients the increase in bone formation leads to an increase in bone mass as manifested by an increase in X-ray density, which in turn leads to a decrease in bone pain and a decrease in fracture rate. These positive effects are limited to the axial skeleton and are not observed in the appendicular skeleton in the dose used. The increase in bone formation is reflected by an increase in serum total alkaline phoshatase activity, which is due to an increase in the bone isoenzyme and which can be used to assess serially the action of fluoride on bone. Serum total alkaline phosphatase activity measurements indicate that, during 2 years of fluoride treatment, about 80% of patients respond and that the magnitude of the response is quite variable. The major disadvantages of fluoride in the treatment of osteoporosis include: (1) All patients do not exhibit a response. (2) Fluoride treatment causes gastric and joint side effects in a significant proportion of patients.

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“…Although this measurement is made at the radius, there is evidence from population surveys that the changes of bone mineral with age measured in the radius are as great or greater than the changes of bone mineral measured in other bones, including vertebra (7,8). Changes in radial mass The Journal of Clinical Investigation Volume 58 September 1976-716-721 may also occur at a faster rate than changes in total body calcium measured by neutron activation (9). Thus, measurement of rate of mineral loss in the radius should adequately reflect changes that occur in the skeleton as a whole.…”

Section: Introductionmentioning

confidence: 99%

Age and activity effects on rate of bone mineral loss.

Smith¹,

Khairi²,

Norton³

et al. 1976

J. Clin. Invest.

137

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A B S T R A C T It has been postulated that the rate of mineral loss in postmenopausal women remains constant with aging and that the decreased activities of daily living associated with aging contribute to mineral loss. These hypotheses were examined by measuring the bone mineral content at the midshaft of the radius with the photon absorption technique. The estimated rate of loss was calculated in a cross-sectional study as the regression coefficient of bone mineral content vs. age and in a longitudinal study as the regression coefficient of bone mineral content vs. time.In the cross-sectional study, Group A, which consisted of 264 women aged 50-72 yr, had an estimated rate of loss of -0.0114±0.0014 (SE) g/cm per yr.Group B, which consisted of 266 women aged 73-96 yr, had an estimated rate of loss of -0.0055+0.0017 g/cm per yr.In the longitudinal study, Group C consisted of 33 women aged 51-65 yr who were followed for an average of 4.5 yr with a mean number of 16 visits per subject; they were found to have a mean rate of loss of -0.00990 ±0.00107 g/cm per yr. Group D consisted of 38 women aged 70-91 yr who were followed for an average of 3.8 yr with a mean number of 31 visits per subjects; they were found to have a mean rate of loss of -0.00020± 0.00236 g/cm per yr.The estimated and directly measured rates of loss were more rapid in the younger groups than in the older groups (A vs. B, P < 0.001; C vs. D, P < 0.001). jects it is significantly slower than that of the earlier postmenopausal years. Since the elderly women were the less active, these findings suggest that factors other than decreased physical activity are more important in determining the rates of mineral loss. INTRODUCTIONThe study of the pathogenesis of postmenopausal osteoporosis has been hampered until recently by the lack of a sufficiently precise method of bone mineral measurement to detect the low rate of mineral loss which ultimately leads to the disease state. Consequently, clinical investigations have been approached primarily by means of cross-sectional (population survey) studies of subjects over a wide age range. These studies have suggested that mineral loss from the skeleton is widespread within the population, if not a universal phenomenon (1)(2)(3)(4)(5). Furthermore, they have demonstrated that a primary consequence of the reduction of bone mineral is an increase in the incidence of fractures (1, 3-5).The inability to directly measure rates of mineral loss has largely prevented further studies such as the relationship of rates of loss to the development of osteoporosis, i.e., to determine if osteoporotics are rapid or slow losers of mineral, and the variables which affect rates of mineral loss. Recently, the value of the photon absorption technique to measure rates of loss of mineral has been demonstrated (6). The precision of the photon absorption method and ability to make multiple measurements on the same individual has made the direct measurement of rates feasible in longitudinal studies (6). Although this measurement is made...

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Relationship between local and total bone mass in osteoporosis

Cited by 84 publications

References 12 publications

Calcium Balance in Uremia: Longitudinal Study of Long-Term Survivors

Calcium Balance in Uremia: Longitudinal Study of Long-Term Survivors

Monofluorophosphate Physiology: The Effects of Fluoride on Bone

Age and activity effects on rate of bone mineral loss.

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