Relationship between limbic and cortical 5-HT neurotransmission and acquisition and reversal learning in a go/no-go task in rats

Masaki, Daiki; Yokoyama, Chihiro; Kinoshita, Shingo; Tsuchida, Hideto; Nakatomi, Yasuhito; Yoshimoto, Kanji; Fukui, Kenji

doi:10.1007/s00213-006-0559-0

Cited by 67 publications

(58 citation statements)

References 55 publications

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“…Relevant to the behavioral inhibition hypothesis, 5-HT depletion also impaired the ability to inhibit in go/no-go tasks, possibly because their ability to withhold responding was impaired (Harrison et al, 1999;Masaki et al, 2006). However, conventional go/no-go tasks also contain a decision-making component in selectionFthe go or no-go response, and 5-HT function is clearly implicated in aspects of decision-making across species on other tasks such as reversal learning (Clark et al, 2004(Clark et al, , 2005Ruotsalainen et al, 1997;Ward et al, 1999).…”

Section: -Ht Depletion Impairs Waiting But Not Ssrtmentioning

confidence: 97%

“…For example, premature response control ('waiting') on the rat 5-CSRT task and human CPT is influenced by 5-HT receptor manipulations and central 5-HT depletion (Carli et al, 2006;Carli and Samanin, 2000;Dougherty et al, 2007;Harrison et al, 1997;Robinson et al, 2007;Walderhaug et al, 2002Walderhaug et al, , 2008. Furthermore, 5-HT depletion also impaired go/no-go inhibition in rats and hostile aggressive children with ADHD (Harrison et al, 1999;Masaki et al, 2006;Zepf et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Serotonin Depletion Impairs Waiting but not Stop-Signal Reaction Time in Rats: Implications for Theories of the Role of 5-HT in Behavioral Inhibition

Eagle

Lehmann

Theobald

et al. 2008

Neuropsychopharmacol

121

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Central serotonin (5-HT) function is thought to be a critical component of behavioral inhibition and impulse control. However, in recent clinical studies, 5-HT manipulations failed to affect stop-signal reaction time (SSRT), which is a fundamental process in behavioral inhibition. We investigated the effect of central 5-HT depletion (intracerebroventricular 5,7-dihydroxytryptamine) in rats on two aspects of behavioral inhibition, SSRT and 'waiting', using the stop-signal task. 5-HT depletion had no effects on SSRT or any other primary measure on the stop-signal task. However, within the same task, there was a deficit in 'waiting' in 5-HT-depleted rats when they were required to withhold from responding in the terminal element of the stop-signal task for an extended period. D-Amphetamine had dosedependent, but not 5-HT-dependent effects on SSRT. Conversely, the dose that tended to improve, or decrease, SSRT (0.3 mg/kg) impaired the ability to wait, again independently of 5-HT manipulation. These findings suggest that SSRT and 'waiting' are distinct measures of behavioral inhibition, and show that 5-HT is critical for some forms of behavioral inhibition but not others. This has significant implications for the treatment of conditions such as attention deficit and hyperactivity disorder, substance abuse, and affective disorders, in which inhibitory and impulse-control deficits are common.

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Section: -Ht Depletion Impairs Waiting But Not Ssrtmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Serotonin Depletion Impairs Waiting but not Stop-Signal Reaction Time in Rats: Implications for Theories of the Role of 5-HT in Behavioral Inhibition

Eagle

Lehmann

Theobald

et al. 2008

Neuropsychopharmacol

121

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“…In rats, global 5-HT depletion following intra-cerebroventricular (i. c. v.) infusions of 5,7-DHT (5,7-dihydroxytryptamine) profoundly disrupted the acquisition of action restraint in response to a no-go signal and also impaired the ability of previously trained rats to subsequently inhibit correctly to a no-go signal (Harrison et al 1999) with no change in other task measures. Similarly, rats administered parachloroamphetamine, to induce 5-HT depletion in the brain, showed impaired acquisition of a go/no-go task (Masaki et al 2006).…”

Section: Role Of 5-ht In Action Restraintmentioning

confidence: 98%

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

2008

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Background and rationale The term 'action inhibition' encapsulates the ability to prevent any form of planned physical response. Growing evidence suggests that different 'stages' or even subtypes of action inhibition activate subtly different neuropharmacological and neuroanatomical processes. Objectives In this review, we present evidence from two commonly used and apparently similar behavioural tests, the stop-signal task and the go/no-go task, to determine if these have similar neuroanatomical and neurochemical modulation. Results Whilst performance of the stop-signal and go/no-go tasks is modulated across only subtly different anatomical networks, serotonin (5-HT) is strongly implicated in inhibitory control on the go/no-go but not the stop-signal task, whereas the stop-signal reaction time appears more sensitive to the action of noradrenaline. Conclusions There is clear neuropharmacological and neuroanatomical evidence that stop-signal and go/no-go tasks represent different forms of action inhibition. This evidence translates with remarkable consistency across species. We discuss the possible implications of this evidence with respect to the development of novel therapeutic treatments for disorders in which inhibitory deficits are prominent and debilitating.

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“…There is now considerable evidence linking reversal learning with 5-HT mechanisms, including in rodents (Masaki et al, 2006;Boulougouris et al, 2008;Lapiz-Bluhm et al, 2009), non-human primates (Clarke et al, 2004(Clarke et al, , 2005Walker et al, 2009), and human beings (Park et al, 1994;Rogers et al, 1999a;Evers et al, 2005) based on pharmacological, neurochemical and dietary manipulations, and evidence of genetic polymorphisms in rhesus monkeys (Izquierdo et al, 2007). Generally, reducing brain serotonin, especially in specific regions such as the OFC (eg Clarke et al, 2004), impairs reversal learning.…”

Section: Translational Models Of Impulsivity and Compulsivitymentioning

confidence: 99%

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

Fineberg

Potenza

Chamberlain

et al. 2009

Neuropsychopharmacol

591

468

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Failures in cortical control of fronto-striatal neural circuits may underpin impulsive and compulsive acts. In this narrative review, we explore these behaviors from the perspective of neural processes and consider how these behaviors and neural processes contribute to mental disorders such as obsessive-compulsive disorder (OCD), obsessive-compulsive personality disorder, and impulse-control disorders such as trichotillomania and pathological gambling. We present findings from a broad range of data, comprising translational and human endophenotypes research and clinical treatment trials, focussing on the parallel, functionally segregated, cortico-striatal neural projections, from orbitofrontal cortex (OFC) to medial striatum (caudate nucleus), proposed to drive compulsive activity, and from the anterior cingulate/ventromedial prefrontal cortex to the ventral striatum (nucleus accumbens shell), proposed to drive impulsive activity, and the interaction between them. We suggest that impulsivity and compulsivity each seem to be multidimensional. Impulsive or compulsive behaviors are mediated by overlapping as well as distinct neural substrates. Trichotillomania may stand apart as a disorder of motor-impulse control, whereas pathological gambling involves abnormal ventral reward circuitry that identifies it more closely with substance addiction. OCD shows motor impulsivity and compulsivity, probably mediated through disruption of OFC-caudate circuitry, as well as other frontal, cingulate, and parietal connections. Serotonin and dopamine interact across these circuits to modulate aspects of both impulsive and compulsive responding and as yet unidentified brain-based systems may also have important functions. Targeted application of neurocognitive tasks, receptor-specific neurochemical probes, and brain systems neuroimaging techniques have potential for future research in this field.

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Relationship between limbic and cortical 5-HT neurotransmission and acquisition and reversal learning in a go/no-go task in rats

Cited by 67 publications

References 55 publications

Serotonin Depletion Impairs Waiting but not Stop-Signal Reaction Time in Rats: Implications for Theories of the Role of 5-HT in Behavioral Inhibition

Serotonin Depletion Impairs Waiting but not Stop-Signal Reaction Time in Rats: Implications for Theories of the Role of 5-HT in Behavioral Inhibition

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

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