Relationship between life-time exposure to ambient fine particulate matter and carotid artery intima-media thickness in Australian children aged 11–12 years

Guo, Yang; Ampon, R; Hanigan, Ivan; Knibbs, Luke D.; Geromboux, Christy; Su, Ta‐Chen; Negishi, Kazuaki; Poulos, L; Morgan, Geoffrey; Marks, Guy B.; Jalaludin, Bin

doi:10.1016/j.envpol.2021.118072

Cited by 8 publications

(12 citation statements)

References 45 publications

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“…Although prior research has not examined the link between air pollution, HIV and subclinical vascular disease, exposure to even mild levels of air pollution similarly has been shown to contribute to atherosclerotic changes during childhood. Findings from a large longitudinal study in Australia in 1063 uninfected children aged 11 -12 years found that IMT was significantly associated with PM 2.5 concentration after adjusting for confounders, suggesting that life-time exposure to low levels of PM 2.5 at a young age could have an adverse impact on vascular structure [29].…”

Section: Discussionmentioning

confidence: 99%

Ambient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents

Toe

Nagy

Albar

et al. 2022

Aids

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Objective: In this study, we aim to investigate the relationship between particulate matter, a common proxy indicator for air pollution, and markers of inflammation, monocyte activation, and subclinical vascular disease.Design: A cross-sectional study.Methods: Adolescents with perinatally acquired HIV (PHIV) and HIV-uninfected adolescents between 10 and 18years living near Kampala, Uganda were included. Daily ambient concentrations of particulate matter (PM 2.5 ) were measured from the Eastern Arica GEOHealth Hub. Outcome variables measured were carotid intimamedia thickness (IMT), as well as plasma markers of systemic inflammation, oxidized lipids, and gut integrity. Multivariable quantile regression models were used to explore the relationship between PM 2.5 and IMT.Results: One hundred and nineteen participants (69 PHIV, 50 HIV-uninfected) were included. The median (Q1, Q3) age was 12.7 (11.4,14.2) years, 55% were girls. Median daily PM 2.5 exposure was 29.08 mg/m 3 (23.40, 41.70). There was no significant difference in exposure of PM 2.5 between groups (P ¼ 0.073). PM 2.5 significantly correlated with intestinal permeability (zonulin; r ¼ 0.43, P < 0.001), monocyte activation (soluble CD163: r ¼ 0.25, P ¼ 0.053), and IMT (r ¼ 0.35, P ¼ 0.004) in PHIV but not in HIV-uninfected (P ! 0.05). In multivariable quantile regression, after adjusting for age, sex, poverty level, soluble CD163, and zonulin, daily PM 2.5 concentrations remained associated with IMT [b ¼ 0.005, 95% CI (0.0003-0.010), P ¼ 0.037] in adolescents with PHIV. Conclusion:Adolescents in urban Uganda are exposed to high levels of air pollution. Both PM 2.5 and HIV have independently been observed to contribute to atherosclerotic disease, and our findings suggest the combined effects of HIV and air pollution may amplify the development of cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Ambient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents

Toe

Nagy

Albar

et al. 2022

Aids

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“…This study demonstrated the positive associations between PM 2.5 and CIMTs in young populations, which agrees with a recent study in Australian children aged 11–12 years . The individuals in the present study were exposed to higher annual exposure concentrations of PM 2.5 (24.9 μg/m 3 ) than those reported in published studies in Western countries and may contribute to this particular finding. , Nevertheless, the point estimate of the percent difference in CIMT with PM 2.5 exposure (0.92% with exposure to 4.5 μg/m 3 PM 2.5 ) in the present study was lower than that in a previous meta-analysis, showing that a 5 μg/m 3 increase in long-term exposure to PM 2.5 is associated with a 1.66% change in CIMT .…”

Section: Discussionmentioning

confidence: 99%

“…Breton et al (2012) also demonstrated that the estimate of CIMT with cumulative O 3 exposure is stronger among subjects who have been exposed since early childhood than those exposed later in life . The point estimates in our study are also lower than those in Australian children with estimates equivalent to 2% increase of CIMT with 1.8 μg/m 3 lifetime exposure of PM 2.5 , which may suggest the geographical and individual heterogenicity in the relationship between PM 2.5 and subclinical atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported that gaseous pollutants, including nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), and ozone, were associated with a variety of markers of vascular damage in children or young adults; however, they have failed to demonstrate the relationships between particulate matter and carotid intima-media thickness (CIMT). − Nevertheless, an epidemiological study of children in the Netherlands reported that PM 2.5 was associated with decreased carotid artery distensibility, a surrogate of atherosclerosis . An Australian study first demonstrated the relationship between PM 2.5 and CIMTs in children aged 11–12 years, but whether PM 2.5 exposure accelerates atherosclerotic process in adolescents or young adults is not evident. The variation of individual characteristics and source-specific air pollutants is considered to result in heterogeneous findings.…”

Section: Introductionmentioning

confidence: 99%

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Urban Fine Particulate Matter and Elements Associated with Subclinical Atherosclerosis in Adolescents and Young Adults

Chen

et al. 2022

Environ. Sci. Technol.

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The relationships between the elemental constituents of PM2.5 and atherosclerosis remain limited, especially in young populations. This study included 755 subjects aged 12–30 years in the Taipei metropolis. A land use regression model was used to estimate residential annual mean concentrations of PM2.5 and eight elemental constituents. We evaluated the percent differences in carotid intima-media thickness (CIMT) with PM2.5 and elemental constituent exposures by linear regressions. Interquartile range increments for PM2.5 (4.5 μg/m3), sulfur (108.6 ng/m3), manganese (2.0 ng/m3), iron (34.5 ng/m3), copper (3.6 ng/m3), and zinc (20.7 ng/m3) were found to associate with 0.92% (95% confidence interval (CI): 0.17–1.66), 0.51% (0.02–1.00), 0.36% (0.05–0.67), 0.98% (0.15–1.82), 0.74% (0.01–1.48), and 1.20% (0.33–2.08) higher CIMTs, respectively. Factor analysis identified four air pollution source-related factors, and the factors interpreted as traffic and industry sources were associated with higher CIMTs. Stratified analyses showed the estimates were more evident in subjects who were ≥18 years old, females, or who had lower household income. Our study results provide new insight into the impacts of source-specific air pollution, and future research on source-specific air pollution effects in young populations, especially in vulnerable subpopulations, is warranted.

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“…Association between PM and health-related disease has been explored by animal models and populationbased studies [12][13], but the results were not generally consistent. Long-term exposure to PM was demonstrated as an important risk factor for CIMT in both cross-sectional and longitudinal studies among late midlife women [14] or women transitioning through menopause [15], adolescents or young adults [16], children [17], general population [18,19] and even HIV-positive adolescents [20]. But such association was not found in some other studies for either PM 2.5 [21,22] or PM 10 [16].…”

Section: Introductionmentioning

confidence: 99%

Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

Han

Zhao

et al. 2022

Preprint

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Background Time-location information, including time spent indoors and outdoors around residential and work places and on commuting, physical activity, infiltrated ambient pollution and traffic transportations, was less considered estimating individual exposure to ambient pollution. Studies investigating the association between individual exposure to particulate matter (PM) with aerodynamic diameter <10 μm (PM10) and <2.5 μm (PM2.5) and carotid atherosclerosis obtained inconsistent results. Moreover, combined effect of mixed pollutants on carotid atherosclerosis was not fully explored because of high collinearity. We aimed to investigate the association between long-term individual time-weighted exposure to PM2.5 and PM10 and the risk of carotid atherosclerosis, and further explore the overall effects of multiple pollutants on carotid atherosclerosis. Methods Daily concentration of ambient pollutants was estimated by land-use regression model at both residential and work addresses, and 1-5 years’ time-weighted individual exposure was calculated by further considering personal activity pattern and infiltrated ambient pollution. We explored the association of PM2.5and PM10 with carotid atherosclerosis and pooled the overall effect of multiple pollutants by quantile g-computation. Results The significant association between time-weighted exposure to PM2.5 and PM10and carotid atherosclerosis was observed. Per interquartile range increase in 2-year exposure to PM2.5 (Hazard ratio (HR): 1.322, 95% confidence interval (CI): 1.219-1.434) and PM10 (HR:1.213, 95% CI: 1.116-1.319) showed the strongest association with carotid atherosclerosis, respectively. Individuals in higher quartiles of pollutants were at higher risk for carotid atherosclerosis. The linear and nonlinear relationships interpreted the upward trend of the risk for carotid atherosclerosis with increasing level of pollutant concentrations. Moreover, the overall adverse effects of multiple pollutants were further demonstrated. Conclusions Individual time-weighted exposure to PM2.5, PM10 and mixed pollutants was associated with carotid atherosclerosis. It is necessary to reduce individual pollutant exposure to inhibit the risk of carotid atherosclerosis and subsequently alleviate disease burdens of atherosclerotic diseases.

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Relationship between life-time exposure to ambient fine particulate matter and carotid artery intima-media thickness in Australian children aged 11–12 years

Cited by 8 publications

References 45 publications

Ambient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents

Ambient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents

Urban Fine Particulate Matter and Elements Associated with Subclinical Atherosclerosis in Adolescents and Young Adults

Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

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