Relationship between left ventricular ejection fraction and mortality in asymptomatic and minimally symptomatic patients with severe aortic stenosis

Bohbot, Y.; Meester, Christophe de; Chadha, Gagandeep; Ruşinaru, Dan; Belkhir, Khadija; Pasquet, Agnès; Maréchaux, Sylvestre; Vanoverschelde, J.-L.; Tribouilloy, Christophe

doi:10.1016/j.acvdsp.2018.10.146

Cited by 5 publications

(7 citation statements)

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“…Intervention should be considered in asymptomatic patients with severe aortic stenosis and systolic LV dysfunction (LVEF <55%) without another cause. 9,240,241 IIa B…”

Section: Cmentioning

confidence: 99%

2021 ESC/EACTS Guidelines for the management of valvular heart disease

Vahanian¹,

Beyersdorf²,

Praz³

et al. 2022

EuroIntervention

547

581

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The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their dating. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of health care or therapeutic strategies. Health professionals are encouraged to take the ESC Guidelines fully into account when exercising their clinical judgment as well as in the determination and the implementation of preventive, diagnostic or therapeutic medical strategies. However, the ESC Guidelines do not override in any way whatsoever the individual responsibility of health professionals to make appropriate and accurate decisions in consideration of each patient's health condition and in consultation with that patient and the patient's caregiver where appropriate and/or necessary. Nor do the ESC Guidelines exempt health professionals from taking careful and full consideration of the relevant official updated recommendations or guidelines issued by the competent public health authorities in order to manage each patient's case in light of the scientifically accepted data pursuant to their respective ethical and professional obligations. It is also the health professional's responsibility to verify the applicable rules and regulations relating to drugs and medical devices at the time of prescription.

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“…Intervention should be considered in asymptomatic patients with severe aortic stenosis and systolic LV dysfunction (LVEF <55%) without another cause. 9,240,241 IIa B…”

Section: Cmentioning

confidence: 99%

2021 ESC/EACTS Guidelines for the management of valvular heart disease

Vahanian¹,

Beyersdorf²,

Praz³

et al. 2022

EuroIntervention

547

581

View full text Add to dashboard Cite

show abstract

“…A study by Bohbot et al. 27 observed a significant reduction in 5‐year survival rates in those with an LVEF < 55% (59% ± 4%) compared to participants with an LVEF between 55%–59% (74% ± 2%) and >60% (72% ± 2%) in asymptomatic or minimally symptomatic severe AS ( p < .001). Findings provided by Dahl et al.…”

Section: A Measure Of Systolic Function: Left Ventricular Ejection Fr...mentioning

confidence: 96%

Current and novel echocardiographic assessment of left ventricular systolic function in aortic stenosis—A comprehensive review

2022

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Aortic stenosis (AS) is a complex and progressive condition that can significantly reduce the quality of life and increase the incidence of premature mortality. Transthoracic echocardiography (TTE) is the gold standard imaging modality for the assessment of AS severity. While left ventricular ejection fraction (LVEF) derived from TTE is a very well-understood parameter, limitations such as high inter and intra-observer variability, insensitivity to sub-clinical dysfunction, and influence of loading conditions make LVEF a complicated and unreliable parameter. Myocardial deformation imaging has been identified as a promising parameter for identifying subclinical left ventricular dysfunction, however, this parameter is still afterload dependent. Myocardial Work is a promising novel assessment technique that accounts for afterload by combining the use of myocardial deformation imaging and non-invasive blood pressure to provide a more comprehensive assessment of mechanics beyond LVEF. This review evaluates the evidence for various echocardiographic assessment parameters used to quantify left ventricular function including myocardial work in patients with AS.

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“…Subsequently, the utilization of a minimally invasive procedure such as transcatheter aortic valve replacement (TAVR) has been validated for patients at high risk for surgical intervention [ 3 , 4 ]. In terms of prognosis, several parameters have been established to predict poor outcomes in patients with AS, including low transvalvular gradient (MPG), low stroke volume index (SVI), and low ejection fraction (EF) [ [5] , [6] , [7] , [8] ]. Systolic dysfunction has long been established to confer poor outcomes after surgical aortic valve replacement (SAVR) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%