Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer

Liu, Y.; Zhang, Q.-Y.; Qian, Ny; Zhou, Ruanbao

doi:10.1093/annonc/mdl394

Cited by 47 publications

(40 citation statements)

References 20 publications

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“…Previous studies indicated that LAPTM4B polymorphism was associated with susceptibility to liver cancer, 26,33 gall bladder carcinoma 26 cervical carcinoma, 34 gastric cancer, 27 breast cancer, 24,25 colon cancer, 28 endometrial carcinoma, 20 and ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

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Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

Hashemi

Rezaei

Narouie

et al. 2016

Molecular & Cellular Oncology

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Lysosome associated protein transmembrane 4 b (LAPTM4B) is an oncogene associated with many human cancers. In the present study we aimed to examine the possible association between LAPTM4B polymorphism and risk of prostate cancer (PCa) in an Iranian population. This case control study was performed on 168 patients with PCa and 176 controls with benign prostatic hyperplasia (BPH). Genomic DNA was extracted from whole blood and LAPTM4B genotypes were identified by polymerase chain reaction. The distributions of LAPTM4B genotypes were significantly different between PCa patients (60.7% for Ã 2 was associated with a decreased risk of PCa but the clinicopathological characteristics of PCa were not linked to LAPTM4B polymorphism. Further studies with larger sample sizes and different ethnicities are needed to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

“…14,[24][25][26][27][28][29][30][31] To the best of our knowledge, there is no report on the impact of LAPTM4B genotype on PCa. Therefore, in the present study we aimed to evaluate the possible association between LAPTM4B gene polymorphism and the risk of PCa in a sample of the Iranian population.…”

Section: Introductionmentioning

confidence: 99%

Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

Hashemi

Rezaei

Narouie

et al. 2016

Molecular & Cellular Oncology

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“…LAPTM4b is a candidate oncogene whose expression is increased in hepatocellular carcinoma, ovarian cancer and gastric cancer (Kasper et al, 2005;Liu et al, 2007;Yang et al, 2010). Furthermore, expression of LAPTM4b contributes to chemotherapy resistance in breast cancer by preventing transport of the anthracycline doxorubicin to the nucleus (Li et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV

Vergarajaúregui

Martina

Puertollano

2011

Journal of Cell Science

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SummaryLoss-of-function mutations in mucolipin 1 (MCOLN1) result in mucolipidosis type IV (MLIV), a lysosomal storage disorder characterized by severe mental and psychomotor retardation. MCOLN1 is a lysosomal ion channel that belongs to the transient receptor potential (TRP) superfamily. To better understand the cellular function of MCOLN1, a split-ubiquitin yeast two-hybrid screen was performed with the purpose of revealing new MCOLN1 interaction partners. The screen identified two members of the lysosomeassociated protein transmembrane (LAPTM) family as novel interaction partners of MCOLN1. The binding between MCOLN1 and LAPTM members (LAPTMs) was confirmed by co-immunoprecipitation and yeast two-hybrid assays. In addition, MCOLN1 and LAPTMs extensively colocalize at late endosomes and lysosomes. Overexpression of LAPTM4b caused enlargement of lysosomes and defective lysosomal degradation, indicating that LAPTMs are important for proper lysosomal function. Interestingly, lysosomal swelling induced by LAPTM4b was rescued by expression of MCOLN1, suggesting a functional connection between the two proteins. Finally, depletion of endogenous LAPTMs by siRNA induced accumulation of concentric multi-lamellar structures and electron-dense inclusions that closely resemble the structures found in MLIV cells. Overall, our data provide new insight into the molecular mechanisms of MCOLN1 function and suggest a potential role for LAPTMs in MLIV pathogenesis.

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“…Allele *1 contains only one copy of a 19-bp sequence at the 5'UTR in the first exon, whereas the sequence in allele *2 is duplicated and tandemly repeated [14]. Previous study showed that LAPTM4B *2/2-type allele was significantly associated with the susceptibility of various adenocarcinoma including breast cancer [15][16][17], HCC [18,19], non-small lung cancer [20], gastric cancer [21], cervical cancer [22], colorectal cancer [23], lymphoma [24], gallbladder carcinoma [25], ovarian carcinoma [26] and malignant melanoma [27]. Therefore, we hypothesized that if there are some specific transcription factors binding to the LAPTM4B polymorphism region which play important roles in regulating LAPTM4B expression.…”

Section: Introductionmentioning

confidence: 99%

The Transcription Factor AP4 Promotes Oncogenic Phenotypes and Cisplatin Resistance by Regulating LAPTM4B Expression

Wang

Yue

et al. 2018

Molecular Cancer Research

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Lysosomal-associated protein transmembrane-4 beta (LAPTM4B) is a novel oncogene, whose overexpression is involved in cancer occurrence and progression.However, the mechanism of LAPTM4B transcriptional regulation remains unclear. In this study, the results of transcription factor (TF) profiling plate arrays indicated that AP4 was a potential transcription factor regulating LAPTM4B expression. LAPTM4B was positively correlated with AP4 and they were both associated with poor overall and disease-free survival. Luciferase and EMSA assays confirmed that AP4 directly bound to the polymorphism region of LAPTM4B promoter and modulated its transcription. Functionally, AP4 promoted cell proliferation, migration, invasion and assisted drug resistance in part through up-regulation of LAPTM4B. Taken together, Implications: This study demonstrates that AP4 promotes cell growth, migration, invasion and cisplatin resistance through up-regulation of LAPTM4B expression, thus representing an attractive therapeutic target for breast cancer.

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Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer

Abstract: This study indicated that allele *2 of LAPTM4B might be the risk factor of gastric cancer, which could be associated with genetic susceptibility of gastric cancer.

Cited by 47 publications

References 20 publications

Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV

The Transcription Factor AP4 Promotes Oncogenic Phenotypes and Cisplatin Resistance by Regulating LAPTM4B Expression

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