Relationship between laboratory mice and the subspecies Mus musculus domesticus based on restriction endonuclease cleavage patterns of mitochondrial DNA.

Yonekawa, Hiromichi; Moriwaki, Kazuo; Gotoh, Osamu; Watanabe, Junko; Hayashi, Jun‐Ichi; Miyashita, Nobumoto; Petras, Michel L.; Tagashira, Yusaku

doi:10.1266/jjg.55.289

Cited by 135 publications

(93 citation statements)

References 27 publications

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“…Although data on RFLPs have placed the divergence inside the Mus musculus species 1-2 million yr ago (Yonekawa et al 1981), long before the ∼370,000 yr ago that we obtained, our estimated coalescence times for the wild-derived strains fall within values obtained more recently with other markers (Suzuki et al 2004). The estimates of coalescence times of the inbred strains, however, were much higher than the known divergence of the strains.…”

Section: Different Mtdna Evolution In Wild and Inbred Strainssupporting

confidence: 73%

mtDNA phylogeny and evolution of laboratory mouse strains

Goios¹,

Pereira²,

Bogue³

et al. 2007

Genome Res.

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Inbred mouse strains have been maintained for more than 100 years, and they are thought to be a mixture of four different mouse subspecies. Although genealogies have been established, female inbred mouse phylogenies remain unexplored. By a phylogenetic analysis of newly generated complete mitochondrial DNA sequence data in 16 strains, we show here that all common inbred strains descend from the same Mus musculus domesticus female wild ancestor, and suggest that they present a different mitochondrial evolutionary process than their wild relatives with a faster accumulation of replacement substitutions. Our data complement forthcoming results on resequencing of a group of priority strains, and they follow recent efforts of the Mouse Phenome Project to collect and make publicly available information on various strains.

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Section: Different Mtdna Evolution In Wild and Inbred Strainssupporting

confidence: 73%

mtDNA phylogeny and evolution of laboratory mouse strains

Goios¹,

Pereira²,

Bogue³

et al. 2007

Genome Res.

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“…The aim of such comparative analysis is to identify conserved, functionally transcribed sequences such as protein-coding genes and non-coding RNA genes, and other functional sequences such as regulatory regions 4,5 , as well as other genomic features. Here, we have compared the entire human chromosome 21 with syntenic regions of the mouse genome, and have identified a large number of conserved blocks of unknown function.…”

Section: Determination Of Snp Low-and High-rate Regionsmentioning

confidence: 99%

“…As a result, we would expect to see in these strains recognizable contributions from several other subspecies such as M. m. musculus (and possibly M. m. castaneus through the hybrid M. m. molossinus). Indeed, most of these inbred laboratory strains carry a M. m. musculus Y chromosome 4 (previous work had shown that most carry M. m. domesticus mitochondrial DNA 5,6 ).…”

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confidence: 99%

The mosaic structure of variation in the laboratory mouse genome

Wade

Kulbokas

Kirby

et al. 2002

Nature

431

376

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Most inbred laboratory mouse strains are known to have originated from a mixed but limited founder population in a few laboratories 1,2 . However, the effect of this breeding history on patterns of genetic variation among these strains and the implications for their use are not well understood. Here we present an analysis of the fine structure of variation in the mouse genome, using single nucleotide polymorphisms (SNPs). When the recently assembled genome sequence from the C57BL/6J strain 3 is aligned with sample sequence from other strains, we observe long segments of either extremely high (,40 SNPs per 10 kb) or extremely low (,0.5 SNPs per 10 kb) polymorphism rates. In all strain-to-strain comparisons examined, only one-third of the genome falls into long regions (averaging >1 Mb) of a high SNP rate, consistent with estimated divergence rates between Mus musculus domesticus and either M. m. musculus or M. m. castaneus. These data suggest that the genomes of these inbred strains are mosaics with the vast majority of segments derived from domesticus and musculus sources. These observations have important implications for the design and interpretation of positional cloning experiments.Patterns of genetic variation provide insight into the evolutionary history of a species and define the complexity of mapping phenotypes in that organism. The commonly used inbred laboratory strains of mice constitute the primary mammalian model system and are an integral component of medical genetic research. These inbred laboratory strains were predominantly derived in the early twentieth century from mouse breeders who originally bred 'fancy' mice (for unusual coat colours and behaviours) as a hobby. Many of the most commonly used strains trace their origins to W. Castle's laboratory at Harvard University and even more strains originate from his supplier A. Lathrop of Granby, Massachusetts. Although these mice are generally thought to reflect predominantly the M. m. domesticus subspecies, there are some historical contributions from 'fancy' mice bred in Japan and China 1,2 (Fig. 1a). As a result, we would expect to see in these strains recognizable contributions from several other subspecies such as M. m. musculus (and possibly M. m. castaneus through the hybrid M. m. molossinus). Indeed, most of these inbred laboratory strains carry a M. m. musculus Y chromosome 4 (previous work had shown that most carry M. m. domesticus mitochondrial DNA 5,6 ).

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“…Two subspecies of mouse, Mus musculus domesticus and M. m. musculus, diverged from their common ancestor 0.3-1.0 MYA (Yonekawa et al 1980;Moriwaki 1994;Bonhomme and Guénet 1996;Boursot et al 1996;Din et al 1996). M. m. domesticus ranges across western Europe and the Middle East, whereas M. m. musculus ranges throughout eastern Europe and northern Asia (Bonhomme and Guénet 1996).…”

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confidence: 99%

Reproductive Isolation in Hybrid Mice Due to Spermatogenesis Defects at Three Meiotic Stages

et al. 2010

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Early in the process of speciation, reproductive failures occur in hybrid animals between genetically diverged populations. The sterile hybrid animals are often males in mammals and they exhibit spermatogenic disruptions, resulting in decreased number and/or malformation of mature sperms. Despite the generality of this phenomenon, comparative study of phenotypes in hybrid males from various crosses has not been done, and therefore the comprehensive genetic basis of the disruption is still elusive. In this study, we characterized the spermatogenic phenotype especially during meiosis in four different cases of reproductive isolation: B6-ChrX MSM , PGN-ChrX MSM , (B6 3 Mus musculus musculus-NJL/Ms) F 1 , and (B6 3 Mus spretus) F 1 . The first two are consomic strains, both bearing the X chromosome of M. m. molossinus; in B6-ChrX MSM , the genetic background is the laboratory strain C57BL/6J (predominantly M. m. domesticus), while in PGN-ChrX MSM the background is the PGN2/Ms strain purely derived from wild M. m. domesticus. The last two cases are F 1 hybrids between mouse subspecies or species. Each of the hybrid males exhibited cell-cycle arrest and/or apoptosis at either one or two of three distinct meiotic stages: premeiotic stage, zygotene-to-pachytene stage of prophase I, and metaphase I. This study shows that the sterility in hybrid males is caused by spermatogenic disruptions at multiple stages, suggesting that the responsible genes function in different cellular processes. Furthermore, the stages with disruptions are not correlated with the genetic distance between the respective parental strains.

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Relationship between laboratory mice and the subspecies Mus musculus domesticus based on restriction endonuclease cleavage patterns of mitochondrial DNA.

Cited by 135 publications

References 27 publications

mtDNA phylogeny and evolution of laboratory mouse strains

mtDNA phylogeny and evolution of laboratory mouse strains

The mosaic structure of variation in the laboratory mouse genome

Reproductive Isolation in Hybrid Mice Due to Spermatogenesis Defects at Three Meiotic Stages

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