Relationship Between Knee Biomechanics and Pain in People With Knee Osteoarthritis: A Systematic Review and <scp>Meta‐Analysis</scp>

Hutchison, Laura; Grayson, Jane; Hiller, Claire E.; D'Souza, N.; Kobayashi, Sarah; Simić, Milena

doi:10.1002/acr.25001

Cited by 16 publications

(13 citation statements)

References 90 publications

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“…Primary osteoarthritis (OA) [ 17 ] is defined as a chronic disabling disease with a familial genetic predisposition [ 18 ], whereas secondary OA is frequently initiated by excessive joint loads or overuse that cause wear and tears at the surface of the articular joint cartilage [ 19 ]. Primary OA is mostly related to overweight, aging, and heredity.…”

Section: Definition and Treatment Of Osteoarthritis (Oa)mentioning

confidence: 99%

Autologous Adipose-Derived Tissue Stromal Vascular Fraction (AD-tSVF) for Knee Osteoarthritis

Vargel

Tuncel

Baysal

et al. 2022

IJMS

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Adipose tissue contains adult mesenchymal stem cells that may modulate the metabolism when applied to other tissues. Stromal vascular fraction (SVF) can be isolated from adipose tissue mechanically and/or enzymatically. SVF was recently used to decrease the pain and improve the function of knee osteoarthritis (OA) patients. Primary and/or secondary OA causes inflammation and degeneration in joints, and regenerative approaches that may modify the natural course of the disease are limited. SVF may modulate inflammation and initiate regeneration in joint tissues by initiating a paracrine effect. Chemokines released from SVF may slow down degeneration and stimulate regeneration in joints. In this review, we overviewed articular joint cartilage structures and functions, OA, and macro-, micro-, and nano-fat isolation techniques. Mechanic and enzymatic SVF processing techniques were summarized. Clinical outcomes of adipose tissue derived tissue SVF (AD-tSVF) were evaluated. Medical devices that can mechanically isolate AD-tSVF were listed, and publications referring to such devices were summarized. Recent review manuscripts were also systematically evaluated and included. Transferring adipose tissues and cells has its roots in plastic, reconstructive, and aesthetic surgery. Micro- and nano-fat is also transferred to other organs and tissues to stimulate regeneration as it contains regenerative cells. Minimal manipulation of the adipose tissue is recently preferred to isolate the regenerative cells without disrupting them from their natural environment. The number of patients in the follow-up studies are recently increasing. The duration of follow up is also increasing with favorable outcomes from the short- to mid-term. There are however variations for mean age and the severity of knee OA patients between studies. Positive outcomes are related to the higher number of cells in the AD-tSVF. Repetition of injections and concomitant treatments such as combining the AD-tSVF with platelet rich plasma or hyaluronan are not solidified. Good results were obtained when combined with arthroscopic debridement and micro- or nano-fracture techniques for small-sized cartilage defects. The optimum pressure applied to the tissues and cells during filtration and purification of the AD-tSVF is not specified yet. Quantitative monitoring of articular joint cartilage regeneration by ultrasound, MR, and synovial fluid analysis as well as with second-look arthroscopy could improve our current knowledge on AD-tSVF treatment in knee OA. AD-tSVF isolation techniques and technologies have the potential to improve knee OA treatment. The duration of centrifugation, filtration, washing, and purification should however be standardized. Using gravity-only for isolation and filtration could be a reasonable approach to avoid possible complications of other methodologies.

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Section: Definition and Treatment Of Osteoarthritis (Oa)mentioning

confidence: 99%

Autologous Adipose-Derived Tissue Stromal Vascular Fraction (AD-tSVF) for Knee Osteoarthritis

Vargel

Tuncel

Baysal

et al. 2022

IJMS

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“…11 It may also limit their overall selfcare ability and motivation, their endurance capacity, their ability to live independently, plus the pursuit of a desirable life quality. [10][11][12] In particular, the older adult suffering from disabling osteoarthritis may be more severely compromised than ever, 8 especially among those cases where COVID-19 post infection symptoms of fatigue, weakness, and dizziness prevail unabated 11 if the oxidative processes associated with COVID-19 further induce abnormal cell-matrix interactions within the osteoarthritic cartilage tissue, 13 as well as exacerbating prevailing levels of inflammation, pain, low selfefficacy perceptions, 14 and matrix damage attributable to the release of destructive enzymes. 15 This is supported by numerous loading studies ranging from those examining the impacts of joint immobilization to those examining the outcomes of excessive joint loading 16 and others that imply that both too little movement as well as excessive repetitive movements can foster cartilage damage or render the bone beneath this tissue noncompliant 17 with dire functional and pain consequences, even if the individual is initially in good health, and especially if the older adult already suffers from osteoarthritis of one or more joints, 18 and is a woman.…”

Section: Osteoarthritismentioning

confidence: 99%

Untitled

2022

IPMRJ

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Background: Osteoarthritis, a highly common, disabling joint disease affecting a large number of older adults is presently incurable, and not always amenable to surgery or pharmacologic interventions.Purpose: Further complicated by multiple past and ongoing COVID-19 pandemic issues and disease consequences, the purpose was to examine what current data reveal as to the prevailing epidemiological features of osteoarthritis and its pathology. Another was to review the utility of some non-pharmacological and non-operative treatment strategies that have been advocated for alleviating the pain and disability of this disease in later life.Methods: Building on a 35 year prior review conducted in 2015, this current review was conducted to identify relevant literature published on this topic over the last 5 years, particularly since COVID-19 onset in 2019. Key words included osteoarthritis, COVID-19, prevention, and intervention. Results:As in prior years, osteoarthritis continues to induce considerable physical disability and consistently impedes the attainment of a high life quality for many older adults. Although not studied to any degree, COVID-19 factors may be expected to render further challenges that compound the disease presentation and its mitigation over time, especially among the long COVID affected older adult. In the face of closures, limited resources, and complex disease presentations, it does appear a variety of non-operative and non-pharmacologic approaches may yet influence the disease process and functional outcomes more positively than not with low safety risks. They may help the older adult more effectively even if surgery is indicated and multiple medications are yet required. Conclusion:The application of one or more carefully designed conservative interventions is likely to reduce the functional disability and pain experienced by older people with any form of osteoarthritis, regardless of whether surgical and or pharmacologic strategies are indicated.

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“…However, when pain scores and facial activity do not fully explain the variation in movement asymmetry in the statistical models, the question is whether this assumption is valid. In human research, the difficulties reported in correlating biomechanical parameters to self-reports of pain illustrate that movement asymmetry may not represent the full pain experience (as reviewed by Hutchison et al, 2022). Instead, facial expressions of pain in humans are sensitive and specific (Kunz et al, 2004;Prkachin & Solomon, 2009).…”

Section: Using Movement Asymmetry As a Proxy For Painmentioning

confidence: 99%

The look of lameness - Behaviors and facial expressions associated with orthopedic pain in horses

Ask¹

2022

Acta Universitatis Agriculturae Sueciae

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There are increasing concerns about equine welfare in equestrian sports, where early detection of orthopedic pain remains a major challenge since reliable and valid pain assessment tools are lacking. Movement asymmetry may be present in horses perceived as free from lameness by their owners, as well as in horses with confirmed orthopedic pain. It is therefore important to differentiate movement asymmetry due to pain from that due to other reasons, which may be achievable by improving orthopedic pain assessment. The aim of this thesis was thus to identify body behaviors and changes in facial activity related to orthopedic pain and movement asymmetry in horses. Progression and regression of movement asymmetry after induced orthopedic pain was monitored and measured with gait analysis in eight horses. A number of behaviors including altered posture, head position, location in the box stall, focus and human interaction were found to be associated with orthopedic pain, as were facial expressions. Only one of four equine pain scales tested detected orthopedic pain reliably and accurately. Dynamic and diverse facial displays were identified in resting and moving horses during pain, illustrating that the concept of one prototypical pain face may be a simplification of the full pain-related facial repertoire. Horses trotted by hand showed a great inter-individual variation in facial expressiveness, highlighting the need for further analysis of facial activity during motion before its use for pain detection. The new knowledge on the relationship between pain and movement asymmetry provided in this thesis, can lead to improved pain assessments, pain management and equine welfare.

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Relationship Between Knee Biomechanics and Pain in People With Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

Cited by 16 publications

References 90 publications

Autologous Adipose-Derived Tissue Stromal Vascular Fraction (AD-tSVF) for Knee Osteoarthritis

Autologous Adipose-Derived Tissue Stromal Vascular Fraction (AD-tSVF) for Knee Osteoarthritis

Untitled

The look of lameness - Behaviors and facial expressions associated with orthopedic pain in horses

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