Relationship between Keloid and Hypertension

Arima, Juri; Ogawa, Rei; Iimura, Takeshi; Azuma, H.

doi:10.1272/jnms.79.494

Cited by 7 publications

(3 citation statements)

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“…With regard to circulation dynamics, many cases of severe keloid are associated with high blood pressure (hypertension). 51 , 52 An analysis of 100 consecutive patients with keloid in our department revealed that patients with large keloids (more than 10 cm 2 ) were significantly more likely to have hypertension than patients with mild keloids (less than 10 cm 2 ). 51 This study suggests that either hypertension adversely affects keloid tissues at a physiological level (eg, by elevating tissue pressure, capillary growth, or endothelial damage) or keloids and hypertension share an etiological mechanism.…”

Section: Hypotheses On the Etiology Of Pathological Scarringmentioning

confidence: 99%

Keloids and Hypertrophic Scars

Huang

Murphy

Akaishi

et al. 2013

Plastic and Reconstructive Surgery Global Open

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122

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Summary:The development of cutaneous pathological scars, namely, hypertrophic scars (HSs) and keloids, involves complex pathways, and the exact mechanisms by which they are initiated, evolved, and regulated remain to be fully elucidated. The generally held concepts that keloids and HSs represent “aberrant wound healing” or that they are “characterized by hyalinized collagen bundles” have done little to promote their accurate clinicopathological classification or to stimulate research into the specific causes of these scars and effective preventative therapies. To overcome this barrier, we review here the most recent findings regarding the pathology and pathogenesis of keloids and HSs. The aberrations of HSs and keloids in terms of the inflammation, proliferation, and remodeling phases of the wound healing process are described. In particular, the significant roles that the extracellular matrix and the epidermal and dermal layers of skin play in scar pathogenesis are examined. Finally, the current hypotheses of pathological scar etiology that should be tested by basic and clinical investigators are detailed. Therapies that have been found to be effective are described, including several that evolved directly from the aforementioned etiology hypotheses. A better understanding of pathological scar etiology and manifestations will improve the clinical and histopathological classification and treatment of these important lesions.

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Section: Hypotheses On the Etiology Of Pathological Scarringmentioning

confidence: 99%

Keloids and Hypertrophic Scars

Huang

Murphy

Akaishi

et al. 2013

Plastic and Reconstructive Surgery Global Open

Self Cite

122

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“…There are reports of association of hypertension with keloid and hypertrophic scar indicating a common etiology of elevated ACE expression [34][35][36]. In a study by Arima et al [37] it was observed that there was increased incidence of hypertension in patients who had more than 3 in number keloids and larger than 10cm…”

Section: Ace Inhibitors and Fibrosismentioning

confidence: 99%

“…2 keloids [37]. Iannello et al [38] presented 2 case reports using low-dose enalapril to treat postoperative keloids.…”

Section: Ace Inhibitors and Fibrosismentioning

confidence: 99%

Effect of Enalapril on Hypertrophic Scars and Keloids

Vijayakumar

Sanghvi

Murdeshwar

2015

J. Adv. Plast. Surg. Res.

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Scarring is a major concern to patient and surgeon following any kind of trauma. Excessive scarring can dramatically affect a patient’s quality of life, both physically and psychologically. Incidence rates of hypertrophic scarring vary from 40% to 70% following surgery to up to 91% following burn injury, depending on the depth of the wound. Most current treatment give unsatisfactory results. Recent studies have explored the role of tissue Angiotensin receptors in tissue healing. With potential benefit of Angiotensin converting enzyme inhibitors in preventing cardiac and pulmonary fibrosis, its role in cutaneous scarring needs to be explored. There is need for randomized control trials to study the role of Enalapril in cutaneous scarring. Angiotensin converting enzyme inhibitors and angiotensin receptor antagonist could be potential candidates for management of hypertrophic scars. Key words: Hypertrophic scars, Keloids, Angiotensin converting enzyme inhibitors, Enalapril.

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