Relationship between irritable bowel syndrome, psychological comorbidities and the consumption of high-fructose corn syrup in a low-income community in a food desert area

Paripati, Nikita; Dugan, Connor; Nesi, Lauren; Mone, Anjali; Patel, Sanket; Gaughan, John; DeSipio, Joshua; Phadtare, Sangita

doi:10.1016/j.nutos.2022.10.001

Cited by 2 publications

(4 citation statements)

References 33 publications

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“…Previously, we observed a higher consumption of HFCS-containing food items in our IBS patient population [14]. Consistent with that observation, a higher estimated consumption of HFCS in all IBS subtypes relative to control participants was also observed in the present study using ANOVA followed by Dunn's post hoc tests (F(3,41) = 3.4, p = 0.026, Figure 5A).…”

Section: Monthly Hfcs Consumption With Respect To Ibs Groupssupporting

confidence: 93%

“…Surveys were also collected from the participants regarding their demographic information and dietary history. We have described these surveys previously [14]. In brief, the survey included questions about demographic variables (sex, gender, ethnicity/race), lifestyle factors (residence, education level, marital status, household income, persons per household, alcohol, and tobacco use), dietary factors (consumption of HFCS-rich foods), and clinical data (height, weight, type of IBS, colonoscopy/endoscopy, medications, hypertension, diabetes, cholesterol, and psychological comorbidities).…”

Section: Patients and Sample Collectionmentioning

confidence: 99%

“…Recently, we reported a significantly high consumption of HFCS in our IBS patients. These patients suffer from socioeconomic challenges [14]. Our hospital is located in Camden, New Jersey.…”

Section: Introductionmentioning

confidence: 99%

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Gut Microbiome and Lipidome Signatures in Irritable Bowel Syndrome Patients from a Low-Income, Food-Desert Area: A Pilot Study

Paripati,

Nesi,

Sterrett

et al. 2023

Microorganisms

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Irritable bowel syndrome (IBS) is a common gastroenterological disorder with triggers such as fructose. We showed that our IBS patients suffering from socioeconomic challenges have a significantly high consumption of high-fructose corn syrup (HFCS). Here, we characterize gut microbial dysbiosis and fatty acid changes, with respect to IBS, HFCS consumption, and socioeconomic factors. Fecal samples from IBS patients and healthy controls were subjected to microbiome and lipidome analyses. We assessed phylogenetic diversity and community composition of the microbiomes, and used linear discriminant analysis effect size (LEfSe), analysis of compositions of microbiomes (ANCOM) on highly co-occurring subcommunities (modules), least absolute shrinkage and selection operator (LASSO) on phylogenetic isometric log-ratio transformed (PhILR) taxon abundances to identify differentially abundant taxa. Based on a Procrustes randomization test, the microbiome and lipidome datasets correlated significantly (p = 0.002). Alpha diversity correlated with economic factors (p < 0.001). Multiple subsets of the phylogenetic tree were associated with HFCS consumption (p < 0.001). In IBS patients, relative abundances of potentially beneficial bacteria such as Monoglobaceae, Lachnospiraceae, and Ruminococcaceae were lower (p = 0.007), and Eisenbergiella, associated with inflammatory disorders, was higher. In IBS patients, certain saturated fatty acids were higher and unsaturated fatty acids were lower (p < 0.05). Our study aims first to underscore the influence of HFCS consumption and socioeconomic factors on IBS pathophysiology, and provides new insights that inform patient care.

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Section: Monthly Hfcs Consumption With Respect To Ibs Groupssupporting

confidence: 93%

Section: Patients and Sample Collectionmentioning

confidence: 99%

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Gut Microbiome and Lipidome Signatures in Irritable Bowel Syndrome Patients from a Low-Income, Food-Desert Area: A Pilot Study

Paripati,

Nesi,

Sterrett

et al. 2023

Microorganisms

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“…Dietary intake is a key component in IBS pathophysiology and is known to affect symptom severity and gut microbiome composition of IBS patients [ 49 ]. A recent study in 2022 found significantly elevated high-fructose corn syrup consumption among IBS patients in low SES communities, indicating that both cultural and financial dietary variations may impact IBS subtype distribution among different populations [ 50 ]. Additional investigation is needed to further elucidate the role of cultural factors and diet on IBS symptoms in the background of a multiracial and socioeconomically diverse population.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Irritable Bowel Syndrome in a Large Academic Safety-Net Hospital

Cheng,

Lee,

Garniene

et al. 2024

JCM

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(1) Background: Irritable bowel syndrome (IBS) is a highly prevalent disorder of gut–brain interaction (DGBI) that is known to reduce the quality of life and raise healthcare costs. The aim of this study was to describe the epidemiology of IBS in a large multiracial academic safety-net hospital. (2) Methods: An electronic query was performed using ICD-9 codes to identify 740 IBS outpatients seen at the Boston Medical Center (BMC) between 1 January 2005 and 30 September 2007. Demographic data were collected from electronic medical records. Bivariate analyses using chi-square tests and ANOVA were used to calculate the significance of categorical and continuous dependent variables, respectively. (3) Results: Compared with the general BMC outpatient population, the IBS cohort consisted of significantly higher proportions of White and Asian patients and lower proportions of Black and Hispanic patients (p < 0.0001). White and Asian patients predominantly had private insurance, while Black and Hispanic patients mostly had government/state-funded or no insurance (p < 0.0001). The IBS subgroup frequencies were similar across racial groups; however, Hispanic patients had IBS with constipation (32%, p < 0.02) more often compared to non-Hispanic patients. (4) Conclusions: Significant differences were found across the racial groups studied in this large outpatient IBS cohort. These findings are likely attributed to racial and socioeconomic disparities in healthcare access and utilization.

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Relationship between irritable bowel syndrome, psychological comorbidities and the consumption of high-fructose corn syrup in a low-income community in a food desert area

Cited by 2 publications

References 33 publications

Gut Microbiome and Lipidome Signatures in Irritable Bowel Syndrome Patients from a Low-Income, Food-Desert Area: A Pilot Study

Gut Microbiome and Lipidome Signatures in Irritable Bowel Syndrome Patients from a Low-Income, Food-Desert Area: A Pilot Study

Epidemiology of Irritable Bowel Syndrome in a Large Academic Safety-Net Hospital

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