Relationship between iron deficiency anemia and febrile seizures in children: A systematic review and meta-analysis

Kwak, Byung Ok; Kim, Kyungmin; Kim, Soo-Nyung; Lee, Ran

doi:10.1016/j.seizure.2017.09.009

Cited by 46 publications

(45 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Comparison of clinical and laboratory findings of patient and control groups showed that Hb, platelet counts, and blood sodium levels were significantly lower in the FS group than those in the FC and HC groups. It has been shown that iron deficiency anemia may be related to the increased risk of children suffering from FS and is one of the risk factors for FS (15). Similarly, studies have found that the reduction of peripheral blood platelet counts in children with FS may be related to the release of a large number of inflammatory mediators caused by platelet activation caused by infection (16,17).…”

Section: Discussionmentioning

confidence: 99%

Acute Phase Serum Leptin, Adiponectin, Interleukin-6, and Visfatin Are Altered in Chinese Children With Febrile Seizures: A Cross-Sectional Study

et al. 2020

View full text Add to dashboard Cite

Adipokines, including leptin, visfatin, adiponectin, and interleukin-6 (IL)-6, play multiple roles in the pathophysiology of epilepsy and febrile seizures (FS). We aimed to investigate the associations among plasma adipokines, mainly leptin, visfatin, adiponectin, or IL-6, and the prognosis of FS. This prospective cross-sectional study was conducted from January 2017 to December 2018 at the Wuxi Second People' Hospital China. The levels of serum leptin, visfatin, adiponectin, and IL-6 in 55 children with FS (FS group) were compared with 42 febrile children without seizure (FC group) and 48 healthy children (HC group) in an acute phase. The correlation with clinical indicators was determined by logistic regression analysis. Serum adiponectin and IL-6 levels were significantly higher in the FS group than in the FC and HC groups (p < 0.05), but there was no statistical difference between the FC and HC groups. In addition, logistic regression analysis showed that high concentrations of adiponectin and IL-6 were significantly associated with the occurrence of FS. For leptin and visfatin, they were significantly lower in the FS and FC groups than in the normal control group, but there was no statistical difference between the FS and FC groups. Our results suggest that higher plasma levels of IL-6 and adiponectin may serve as an additional biomarker in the early treatment or follow-up of the FS children.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute Phase Serum Leptin, Adiponectin, Interleukin-6, and Visfatin Are Altered in Chinese Children With Febrile Seizures: A Cross-Sectional Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Following these conflicting results, four recent meta-analyses indicated that iron deficiency anemia significantly increased the risk of febrile seizures with an OR of 1.27–3.78 [25–28]. In the meta-analysis by Kwak et al [32], iron deficiency anemia, diagnosed based on plasma ferritin (OR 3.78; 95% CI, 1.80–7.94; P < 0.001) or MCV (OR 2.08; 95% CI, 1.36–3.17; P = 0.001), was associated with febrile seizures. Karimi et al [33] performed subgroup analyses of simple febrile seizures and first febrile seizures, and obtained an OR of 2.98 (95% CI, 1.67–5.31) and 2.23 (95% CI, 1.33–3.73), respectively.…”

Section: Discussionmentioning

confidence: 99%

Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea

2019

View full text Add to dashboard Cite

Background Febrile seizures are the most common type of seizure in the first 5 years of life, and many factors that increase seizure risk have been identified. This study was performed to examine the association between iron status and febrile seizures in children in South Korea. Methods A prospective unmatched case control study was performed in 63 cases of febrile seizures and 65 controls with febrile illness but no seizures. Results Serum iron, plasma ferritin, and transferrin saturation were significantly lower in children with febrile seizures compared to the controls. Iron deficiency, defined as ferritin < 30 ng/mL, was more prevalent in the febrile seizure group (49.2%) than in the control group (16.9%). Serum iron < 22 ng/dL (odds ratio 3.42, 95% confidence interval [CI] 1.31–8.9, P = 0.012) and ferritin < 30 ng/mL (odds ratio 6.18, 95% CI 2.32–16.42, P < 0.001) were associated with increased risk of developing febrile seizures in multivariate logistic regression analysis. Conclusion These observations suggest that iron deficiency prior to development of anemia may increase risk of febrile seizures.

show abstract

“…23,2 Iron deficiency anaemia may predispose to febrile seizures. 22,[24][25][26][27][28][29][30] Studies have also shown that the stress from fever or seizure results in leucocytosis with neutrophilic predominance following release of epinephrine. 31 Recurrence of seizure episodes and concern about epilepsy are major parental concerns regarding long term effects of febrile seizure.…”

mentioning

confidence: 99%

Clinical, epidemiological and laboratory characteristics of children with febrile seizures

Shankar

Mahamud

2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Febrile seizure is the most common type of seizure disorder that occurs in children aged 6-60 months. Recurrences are common. This study was conducted to evaluate the epidemiology, clinical profile and laboratory parameters of children presenting with febrile seizure in a teaching hospital.Methods: This was a descriptive retrospective study among children presenting with febrile seizure admitted to KIMS, Bengaluru from March (2018-2019). Children between six months to five years were included in the study while patients with prior episodes of afebrile seizures, abnormal neurodevelopment and not meeting the age criteria were excluded. Patient’s demographic and clinical data were collected from the in-patient records and analysed.Results: Among 60 children with febrile seizures were enrolled in our study with highest prevalence in males (58%) and amongst 13-24 months age group (37%). Majority (20%) presented in the monsoon season (June) and in the morning hours (43%). Simple febrile seizures and complex febrile seizures were observed in 60% and 40% respectively. Majority (73%) who developed first episode of seizure were below 24 months ago with mean age of 18.71±11.50 months. 42% had recurrence and was significantly associated with first episode of febrile seizures at age ≤1 year and family history of seizures. Upper respiratory tract infections were the commonest cause of fever. Anaemia and leucocytosis were seen in 72% and 70% cases respectively.Conclusions: Febrile seizure was observed predominantly in children below two years, simple febrile seizure being the commonest. Recurrence was common and significantly associated with the first episode of febrile seizure at the age one year or below and family history. Majority had anaemia which showed that iron deficiency anaemia could be a risk factor. Leucocytosis was present in most which could be either due to underlying infection or due to the stress of seizure itself.

show abstract

Relationship between iron deficiency anemia and febrile seizures in children: A systematic review and meta-analysis

Abstract: The results of this meta-analysis suggest that IDA is associated with an increased risk of FS in children.

Cited by 46 publications

References 39 publications

Acute Phase Serum Leptin, Adiponectin, Interleukin-6, and Visfatin Are Altered in Chinese Children With Febrile Seizures: A Cross-Sectional Study

Acute Phase Serum Leptin, Adiponectin, Interleukin-6, and Visfatin Are Altered in Chinese Children With Febrile Seizures: A Cross-Sectional Study

Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea

Clinical, epidemiological and laboratory characteristics of children with febrile seizures

Contact Info

Product

Resources

About