Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes: a case-series report

Gómez‐Marcos, Manuel A.; Recio-Rodríguez, José I.; Patino-Alonso, María C.; Agudo‐Conde, Cristina; Gómez‐Sánchez, Leticia; Rodríguez‐Sánchez, Emiliano; Martín-Cantera, Carlos; García‐Ortiz, Luis

doi:10.1186/1475-2840-10-3

Cited by 42 publications

(37 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[25,26]. These findings have been supported by clinical observations, which have shown associations between increased aortic PWV and type 1 or type 2 DM [5,27,28]. In accordance with previous studies, we demonstrate increased aortic stiffness in STZ-diabetic rats compared to nondiabetic rats.…”

Section: Discussionsupporting

confidence: 92%

Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes

Salum

Kampus

Zilmer

et al. 2012

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundDiabetes mellitus is associated with micro- and macrovascular complications and increased cardiovascular risk. Elevated levels of serum asymmetric dimethylarginine (ADMA) may be responsible for endothelial dysfunction associated with diabetes-induced vascular impairment. Vitamin D may have potential protective effects against arterial stiffening. This study aimed to examine both the effects of diabetes on the functional/structural properties of the aorta and the endothelial function and the effects of vitamin D supplementation.MethodsMale Wistar rats (n = 30) were randomly assigned to control untreated, diabetic untreated, and diabetic + cholecalciferol groups. Diabetes was induced by intraperitoneal injection of streptozotocin, followed by oral administration of cholecalciferol (500 IU/kg) for 10 weeks in the treatment group. Aortic pulse wave velocity (PWV) was recorded over a mean arterial pressure (MAP) range of 50 to 200 mmHg using a dual pressure sensor catheter. Intravenous infusion of phenylephrine and nitroglycerine was used to increase and decrease MAP, respectively. Serum 25-hydroxyvitamin D [25(OH)D] levels were measured using a radioimmune assay. ADMA levels in serum were measured by enzyme-linked immunoassay. Aortic samples were collected for histomorphometrical analysis.ResultsPWV up to MAP 170 mmHg did not reveal any significant differences between all groups, but in diabetic rats, PWV was significantly elevated across MAP range between 170 and 200 mmHg. Isobaric PWV was similar between the treated and untreated diabetic groups, despite significant differences in the levels of serum 25(OH)D (493 ± 125 nmol/L vs 108 ± 38 nmol/L, respectively). Serum levels of ADMA were similarly increased in the treated and untreated diabetic groups, compared to the control group. The concentration and integrity of the elastic lamellae in the medial layer of the aorta was impaired in untreated diabetic rats and improved by vitamin D supplementation.ConclusionPWV profile determined under isobaric conditions demonstrated differential effects of uncontrolled diabetes on aortic stiffness. Diabetes was also associated with elevated serum levels of ADMA. Vitamin D supplementation did not improve the functional indices of aortic stiffness or endothelial function, but prevented the fragmentation of elastic fibers in the aortic media.

show abstract

Section: Discussionsupporting

confidence: 92%

Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes

Salum

Kampus

Zilmer

et al. 2012

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…This suggests reliability and validity problems. In any case, as has been reported elsewhere, 26,27 it must be remembered that the association between PWV and other arterial stiffness parameters behaves differently depending on the patient disease; as a result, the measures are not inter-exchangeable in clinical practice. As a main limitation to our study, the reference standard used was not an invasive method but the SphygmoCor, which has already been validated vs. invasive techniques, and is known to slightly underestimate CASP depending on the calibration method used.…”

Section: Discussionmentioning

confidence: 69%

Comparison of two measuring instruments, B-pro and SphygmoCor system as reference, to evaluate central systolic blood pressure and radial augmentation index

García‐Ortiz¹,

Recio-Rodríguez²,

Canales-Reina³

et al. 2012

Hypertens Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, the circulating level of microparticles, oxidized low-density lipoproteins, and intima-media thickness are associated with the arterial elasticity of diabetes patient [42-44]. However, these techniques are expensive and inconvenient, and are therefore not suitable for the early and fast diagnosis of arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

Using the spring constant method to analyze arterial elasticity in type 2 diabetic patients

Wei

Shi

Bau

2012

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundThis study tests the validity of a newly-proposed spring constant method to analyze arterial elasticity in type 2 diabetic patients.MethodsThe experimental group comprised 66 participants (36 men and 30 women) ranging between 46 and 86 years of age, all with diabetes mellitus. In the experimental group, 21 participants suffered from atherosclerosis. All were subjected to the measurements of both the carotid-femoral pulse wave velocity (cfPWV) and the spring constant method. The comparison (control) group comprised 66 normal participants (37 men and 29 women) with an age range of 40 to 80 years who did not have diabetes mellitus. All control group members were subjected to measurement by the spring constant method.ResultsStatistical analysis of the experimental and control groups indicated a significant negative correlation between the spring constant and the cfPWV (P < .001; r = - 0.824 and – 0.71). Multivariate analysis similarly indicated a close relationship. The Student’s t test was used to examine the difference in the spring constant parameter between the experimental and control groups. A P-value less than .05 confirmed that the difference between the 2 groups was statistically significant. In receiver operating characteristic curve (ROC), the Area Under Curve (AUC, = 0.85) indicates good discrimination. These findings imply that the spring constant method can effectively identify normal versus abnormal characteristics of elasticity in normal and diabetic participants.ConclusionsThis study verifies the use of the spring constant method to assess arterial elasticity, and found it to be efficient and simple to use. The spring constant method should prove useful not only for improving clinical diagnoses, but also for screening diabetic patients who display early evidence of vascular disease.

show abstract

Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes: a case-series report

Cited by 42 publications

References 34 publications

Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes

Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes

Comparison of two measuring instruments, B-pro and SphygmoCor system as reference, to evaluate central systolic blood pressure and radial augmentation index

Using the spring constant method to analyze arterial elasticity in type 2 diabetic patients

Contact Info

Product

Resources

About