Relationship between interleukin-6 polymorphism and susceptibility to chronic hepatitis B virus infection

Zhao, Xiaomiao; Gao, Yufeng; Zhou, Qin; Pan, Faming; Xu, Li

doi:10.3748/wjg.v19.i40.6888

Cited by 16 publications

(17 citation statements)

References 26 publications

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“…IL-6 also induces an inhibitory effect on HBV replication [41]. In addition, IL-6 polymorphisms have been shown to have a close relationship to HBV infection [42]. Therefore, in this section, we focused on the influence of IL-6 and its polymorphisms on HBV infection.…”

Section: Effects Of Il-6 On Hepatitis B Infectionmentioning

confidence: 99%

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Involvement of Interleukin 6 in Hepatitis B Viral Infection

Xia

Liu

Chen

et al. 2015

Cell Physiol Biochem

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Hepatitis B is a major global health problem and a potentially life-threatening liver infection caused by hepatitis B virus (HBV). Many cytokines including interleukin 6 (IL-6) have been shown to be involved in the HBV infection process. IL-6 is a typical cytokine made up of 184 amino acids, and the gene is located in chromosome 7p21. For healthy people, serum IL-6 levels are usually too low to be detected. However, dysregulated synthesis of IL-6 has been discovered in chronic inflammatory diseases such as hepatitis B, Crohn's disease and rheumatoid arthritis. IL-6 also plays an important role in HBV replication and in the development of hepatitis B disease. This review aims to present the latest discoveries concerning the role of IL-6 in hepatitis B disease progression, and HBV entry and replication, and evaluate polymorphisms that are associated with the development of hepatitis B disease.

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Section: Effects Of Il-6 On Hepatitis B Infectionmentioning

confidence: 99%

“…Single nucleotide polymorphisms (SNPs) play a role in causing the diversity of HBV clinical courses. Recent studies have demonstrated that IL-6 polymorphisms are involved with chronic HBV infection progression [42].…”

Section: Relationship Between Il-6 Polymorphisms and The Development mentioning

confidence: 99%

Involvement of Interleukin 6 in Hepatitis B Viral Infection

Xia

Liu

Chen

et al. 2015

Cell Physiol Biochem

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“…Previous genetic association studies have reported a protective effect of the A allele in rs2069837 in late-onset Alzheimer's disease, cervical cancer, chronic hepatitis B virus infection, colorectal cancer, and hepatocellular carcinoma (11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

“…The Takayasu arteritis associated risk allele in this variant is associated with longevity, spastic tetraplegia, cerebral palsy, and antipsychotic-induced weight gain (7)(8)(9)(10). In contrast, the Takayasu arteritis risk allele in rs2069837 was shown to be protective against late-onset Alzheimer's disease, cervical cancer, chronic hepatitis B virus infection, colorectal cancer, and hepatocellular carcinoma (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 95%

Multi-disease associated risk locus inIL6represses the anti-inflammatory geneGPNMBthrough chromatin looping and recruiting MEF2-HDAC complex

Kong

Sawalha

2019

Preprint

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We have previously revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within IL6 (rs2069837 A/G). The risk allele in this variant (allele A) has a protective effect against chronic viral infection and cancer. Using a combination of experimental and bioinformatics tools, we identified the monocyte/macrophage anti-inflammatory gene GPNMB, ~520kb away, as a target gene regulated by rs2069837. We revealed preferential recruitment of myocyte enhancer factor 2-histone deacetylase (MEF2-HDAC) repressive complex to the Takayasu arteritis risk allele. Further, we demonstrated suppression of GPNMB expression in monocyte-derived macrophages from healthy individuals with the AA compared to AG genotype, which was reversed by histone deacetylase inhibition. Our data suggest that the A allele in rs2069837 represses the expression of GPNMB by recruiting MEF2-HDAC complex, enabled through a long-range intra-chromatin looping mediated by CTCF. Suppression of this anti-inflammatory gene might mediate increased susceptibility in Takayasu arteritis and enhance protective immune responses in chronic infection and cancer. Our data highlight long-range chromatin interactions in functional genomic studies.

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“…This pattern of response to environmental stimuli has been suggested to be genetically influenced and may predispose to chronic inflammatory disorders, as demonstrated by Fishman et al (15). The IL6 gene has been associated with many conditions, such as acute coronary syndrome (16) and end-stage renal disease (17), and with susceptibility to infection with chronic hepatitis B virus (18). Strong evidence indicates that the risk of developing periodontitis, as well as the age at onset of periodontitis and its severity, are affected by genetic and environmental factors (19).…”

mentioning

confidence: 99%

Complete physical mapping of IL6 reveals a new marker associated with chronic periodontitis

Farhat

Souza

Braosi

et al. 2016

J of Periodontal Research

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Relationship between interleukin-6 polymorphism and susceptibility to chronic hepatitis B virus infection

Abstract: The four tag SNPs of IL-6 gene may be associated with susceptibility to chronic HBV infection in the Han Chinese population.

Cited by 16 publications

References 26 publications

Involvement of Interleukin 6 in Hepatitis B Viral Infection

Involvement of Interleukin 6 in Hepatitis B Viral Infection

Multi-disease associated risk locus inIL6represses the anti-inflammatory geneGPNMBthrough chromatin looping and recruiting MEF2-HDAC complex

Complete physical mapping of IL6 reveals a new marker associated with chronic periodontitis

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