Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX

Oh, Sung Yong; Shin, Aesun; Kim, Seong Geun; Hwang, Jaehoon; Hong, Seung Hyun; Lee, Yeon Su; Kwon, Hyuk Chan

doi:10.18632/oncotarget.9100

Cited by 11 publications

(11 citation statements)

References 28 publications

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“…6 Gallagher et al 7 have reported that patients with Laron syndrome have a decreased susceptibility of developing cancer. 17 Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is encoded by the IGF2BP2 gene and acts as an RNA-binding protein of IGF2 mRNA. 8 Recently, some case-control studies have focused on the relationship of IGFBP3 and IGF1 single nucleotide polymorphisms (SNPs) with the risk of cancer.…”

Section: Introductionmentioning

confidence: 99%

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

Tang

Chen

Liu

et al. 2018

J of Cellular Biochemistry

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Esophagogastric junction adenocarcinoma (EGJA) may be associated with obesity and overweight. Thus, any variant in energy metabolism–related gene may influence the development of EGJA. In this study, we recruited 720 EGJA cases and 1541 noncancer controls. We selected IGF2BP2 rs4402960 G > T, rs1470579 A > C, IGF1 rs5742612 A > G and IGFBP3 rs3110697 G > A, rs2270628 C > T and rs6953668 G > A loci and assessed the relationship of these polymorphisms with lymph node status and susceptibility of EGJA. We found that IGF2BP2 rs1470579 A > C and IGFBP3 rs6953668 G > A polymorphisms were associated with the decreased risk of EGJA ( IGF2BP2 rs1470579: CC vs AA: adjusted odds ratio [OR] = 0.65, 95% confidence interval [CI] = 0.43‐0.98, P = 0.041 and CC vs AA/AC: adjusted OR = 0.62, 95% CI = 0.41‐0.93, P = 0.021 and IGFBP3 rs6953668: GA vs GG: adjusted OR = 0.66, 95% CI = 0.47‐0.93, P = 0.019 and GA/AA vs GG: adjusted OR = 0.68, 95% CI = 0.48‐0.95, P = 0.026). However, we also found that IGF1 rs5742612 A > G polymorphism increased the risk of LNM among patients with EGJA (GG vs AA: adjusted OR = 1.88, 95% CI = 1.02‐3.46, P = 0.042 and GG vs AA/AG: adjusted OR = 1.92, 95% CI = 1.06‐3.47, P = 0.032). This study suggests that IGF2BP2 rs1470579 A > C and IGFBP3 rs6953668 G > A polymorphisms may decrease genetic susceptibility to EGJA in eastern Chinese Han population. In addition, our findings also indicate that IGF1 rs5742612 A > G polymorphism may increase the susceptibility of LNM among patients with EGJA.

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Section: Introductionmentioning

confidence: 99%

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

Tang

Chen

Liu

et al. 2018

J of Cellular Biochemistry

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“…This SNP includes rs6214, rs6220, rs35767, and rs5742612. It is reported that the substitution of G to C at the rs5742612 site leads to an increase in plasma IGF1 levels, which increases the risk of the malignant tumor ( 20 ). Since rs5742612 has a relatively small frequency of about 10–40% in the population included in the third phase of the Human 1000 Genome Project, so this study pays special attention to rs5742612 ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Association between insulin-like growth factor 1 gene rs5742612 polymorphism and malignant tumor susceptibility: a meta-analysis

Zhou¹,

Zhang²,

Zheng³

et al. 2021

Transl Cancer Res TCR

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Background: Malignant tumor is a serious threat to human health and life, which is a difficult problem in the world. Insulin-like growth factor 1 (IGF1) is an important mitotic factor in vivo. It usually acts in the way of autocrine and paracrine to control the proliferation, differentiation, and apoptosis of various cells, IGF1 has a strong mitotic and anti-apoptosis activity in malignant cells. Single nucleotide polymorphism (SNP) is an important part of individual genetic variation. A large number of studies have shown that IGF1 SNP associated with the risk of a malignant tumor may be an important biomarker for the diagnosis of malignant tumors. Therefore, the article will investigate the association between rs5742612 polymorphism of IGF1 gene and malignant tumor susceptibility. Methods:We searched for studies in five databases (PubMed, Embase, Web of Science, CNKI and Wanfang) regarding the association between IGF1 gene rs5742612 and malignant tumor susceptibility. Odds ratios (ORs) and the related 95% confidence intervals (CIs) were employed to assess the strength of the associations.Results: Ultimately this study identified seven articles that met the inclusion criteria, involving 2,581 cases and 2,445 controls. There was no significant correlation between IGF1 gene rs5742612 polymorphism and malignant tumor susceptibility [thymidine (T) vs. cytimidine (C),

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“…BCL2 is a well-known anti-apoptosis gene in multiple cancers [ 37 , 38 ]. The IGF axis-pathway SNPs can influence FOLFOX chemotherapy in patients with advanced gastric cancer [ 39 ]. Secreted VEGFC can enhance gastric cancer cell invasion and conferred cisplatin resistance to Rho GDP dissociation inhibitor 2 (RhoGDI2)-overexpressing cells [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis of GLI1 and Related Signaling Pathways in Chemosensitivity of Gastric Cancer

Jia

et al. 2018

Med Sci Monit

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BackgroundThis study assessed the prognostic value of GLI1 in gastric cancer and analyzed the possible GLI1-related signaling network in chemosensitivity.Material/MethodsBioinformatic data mining was performed by using data in the TCGA-Stomach Cancer (TCGA-STAD) and the Kaplan-Meier plotter. GLI1 co-expressed genes in TCGA-STAD were subjected to KEGG pathway analysis. The genes enriched in the KEGG pathways were further subjected to Protein-Protein Interaction (PPI) analysis.ResultsIn TCGA-STAD, high GLI1 gene/exon expression was associated with significantly worse survival (p=0.016 and 0.0023 respectively). In the Kaplan-Meier plotter, high GLI1 expression was associated with unfavorable overall survival (OS) (HR: 1.68, 95%CI: 1.42–2, p<0.0001) and first progression-free survival (FPS) (HR: 1.72, 95%CI: 1.4–2.11, p<0.0001). In TCGA-STAD, 600 GLI1 co-expressed genes were identified (absolute Pearson’s r ≥0.5). The most significant pathways were pathways in cancer (p=230.0E-12) and the Hedgehog signaling pathway (p=6.9E-9). PI3K-AKT pathway (p=17.0E-9) has the largest proportion of gene enrichment. Some GLI1 co-expressed genes in the PI3K-AKT pathway are central nodes in the PPI network and also play important roles in chemosensitivity of gastric cancer. Nevertheless, the mechanisms underlying their co-expression are still largely unexplored.ConclusionsHigh GLI1 expression is associated with unfavorable OS and FPS in patients with gastric cancer. As a member of the Hedgehog signaling pathway, GLI1 co-expressed genes are also largely enriched in PI3K/AKT pathway in gastric cancer, which is closely related to chemoresistance. The underlying mechanisms are still largely unexplored and need further study.

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Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX

Cited by 11 publications

References 28 publications

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

Association between insulin-like growth factor 1 gene rs5742612 polymorphism and malignant tumor susceptibility: a meta-analysis

Bioinformatic Analysis of GLI1 and Related Signaling Pathways in Chemosensitivity of Gastric Cancer

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