Relationship between inflammation and progression of an abdominal aortic aneurysm in a rabbit model based on 18F-FDG PET/CT imaging

Abstract

In the early stages of abdominal aortic aneurysm development, the inflammatory response of the arterial wall is significant, the local metabolic activity is strengthened, the SUVmax value of 18F-FDG is high, and the abdominal aortic aneurysm diameter experiences rapid growth. In the later stages of abdominal aortic aneurysm development, the diameter continues to increase; however, there are decreases in the wall inflammatory response, the local metabolic activity, and the SUVmax value of 18F-FDG. Thus, inflammation plays an important role in the early development of abdominal aortic aneurysm.

Prospect of positron emission tomography for abdominal aortic aneurysm risk stratification

“…[35][36][37] Both preclinical and clinical studies of gold-standard [ 18 F]FDG PET to assess glucose metabolism and inflammation in AAA have yielded varying results of both increased and variable [ 18 F]FDG uptake. [38][39][40][41] Some studies have shown that [ 18 F]FDG PET may be useful to predict AAA expansion and/or progression, 42,43 while other studies have contradicted this. 38,44 40,43,44 In a study of [ 18 F]FDG PET and contrast-enhanced magnetic resonance imaging (MRI), Kuzniar et al demonstrated that the hotspots of [ 18 F]FDG uptake and late gadolinium enhancement rarely coincide in AAA, although both are associated with aneurysm growth, raising interesting questions about the distribution of cellular activity in AAA.…”

“… Species Radiotracer Targeted biomarker Key conclusions 65 Rats [ 18 F]FDG, [ 11 C]PBR28 Aortic wall inflammation AAA wall inflammation can be detected using [ 18 F]FDG and [ 11 C]PBR28 39 Rats [ 18 F]FDG Rupture prediction Increased pre-rupture glucose uptake may be associated with increased inflammation in the ruptured AAA wall 17 Rats [ 64 Cu]DOTA-ECL1i Expression of chemokine receptor 2 There is no change in [ 64 Cu]DOTA-ECL1i uptake from day 7 to day 14 in PPE AAA, regardless of aortic diameter, and there is approx. 2× more uptake in AAA that proceeds to rupture 19 Mice [ 18 F]FLT Cell proliferation [ 18 F]FLT uptake is increased during the active growth phase of AngII AAA compared to that in saline control mice and late-stage AAA 52 Mice [ 18 F]FPPRGD2 α v β 3 expression [ 18 F]FPPRGD2 uptake in AAA may correlate with vascular inflammation and neoangiogenesis but not with AAA diameter 25 Mice [ 18 F]CLIO Macrophages [ 18 F]CLIO may be used to quantify macrophage content in AAA 66 Rats [ 18 F]FDG Intraluminal thrombus occurrence Increased [ 18 F]FDG uptake and growth may be associated with intraluminal thrombus occurrence in AAA 41 …”

Molecular Imaging of Thoracic Aortic Aneurysm Inflammation: A Review of Clinical and Experimental Studies

“…Выводы авторов были подтверждены в экспериментальном исследовании Nie M.X. [46] на биологической модели аневризмы брюшной аорты у кроликов. Автор установил, что на ранних стадиях развития аневризмы отмечается выраженная воспалительная реакция артериальной стенки, усиливается местная метаболическая активность, повышается значение SUVmax 18 F-ФДГ, а диаметр аневризмы брюшной аорты быстро увеличивается.…”

Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm

“…The data on [ 18 F]FDG uptake in AAA are mixed and conflicting. [6][7][8][9] Some studies suggest that increased [ 18 F]FDG uptake positively correlates with AAA progression, [10][11][12] , while others indicate an inverse relationship or lack of correlation between [ 18 F]FDG uptake and aortic size. 13,14 The Sodium Fluoride Imaging of AAA (SoFIA3) trial recently demonstrated that fluorine-18 sodium fluoride AAA uptake (reflecting microcalcification) predicts AAA progression and rupture, providing the first proof-of-concept data for PET/CT as a AAA stratification biomarker 15 ; however, the mechanism remains unclear.…”