Relationship between indices of circulating blood cells and bone homeostasis in osteoporosis

Li, Yuan; Hao, WeiMin; Guan, Jianming; Li, Bo; Li, Meng; Sun, Shi‐Gang; Tianyuan, Sheng; Dong, Shuangxi; Zhou, Qian; Liu, Mingjie; Zhang, Zhiqing Philippe; Shen, Tao; Shen, Yuemao; Zhao, Baobing

doi:10.3389/fendo.2022.965290

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…These data are consistent with the literature. Recently, Li et al [19] investigated a large cohort of osteoporotic patients and healthy subjects (more than 1100 people in total) and reported higher white blood cell, neutrophil and monocyte counts in cases than in controls. These results were con rmed even when the analysis was restricted to men (about 6% of this population).…”

Section: Discussionmentioning

confidence: 99%

“…Speci cally, a close and complex interaction between the immune system and cells involved in bone remodelling has emerged, leading to the genesis of the eld of osteoimmunology [27]. Many factors including immune cells, glutamate signalling, mesenchymal stromal cells, and endothelial cells, play a crucial role in bone homeostasis and thus in osteoporosis [19,[28][29][30]. Non-metastatic [ 18 F]PSMA-1007 bone uptake might be the result of bone remodelling typical of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

“…Osteoporosis is the most common metabolic disease, with an overall prevalence in elderly men worldwide of 12.5% (95% con dence interval: 9.3-16.7%) [18]. We aimed to explore the association between surrogate markers of osteoporosis (i.e., blood count parameters [19], BMI [20], and bone Houns eld Units (HU) values on CT [21]) and the occurrence of non-metastatic bone [ 18 F]PSMA-1007 uptake.…”

Section: Introductionmentioning

confidence: 99%

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The potential role of osteoporosis in unspecific [18F]PSMA-1007 bone uptake

Ninatti,

Pini,

Gelardi

et al. 2023

Eur J Nucl Med Mol Imaging

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We investigated the association between surrogate markers of osteoporosis and the occurrence of nonmetastatic [ 18 F]PSMA-1007 bone uptake. Materials and MethodsWe retrospectively analysed treatment-naïve patients with a con rmed diagnosis of prostate adenocarcinoma who underwent staging [ 18 F]PSMA-1007 Positron Emission Tomography (PET) and blood count within 3 months. Qualitative image analysis was performed independently by three experienced nuclear medicine physicians. Patients were divided in two groups according to the presence/absence of non-metastatic bone uptake. Clinical information, blood count parameters, Body Mass Index (BMI) and bone density as estimated by Computed Tomography were collected. The Kruskal-Wallis and t-test were used to compare parameters. ResultsWe analysed 77 patients: 29 of them had non-metastatic bone uptake at [ 18 F]PSMA-1007 PET, most commonly in the pelvic bones (69%) and ribs (62%). Clinical parameters did not differ in the two groups.In patients with non-metastatic bone uptake, white blood cell and neutrophil counts were signi cantly higher; in the same group, we observed lower values of BMI and bone density, although not statistically different. ConclusionsWe observed non-metastatic bone uptake on [ 18 F]PSMA-1007 PET in more than 1/3 of patients. We found a signi cant correlation between blood count parameters and non-metastatic [ 18 F]PSMA-1007 bone uptake. Given the prevalence of the nding and the molecular alterations induced by osteoclastogenic processes, we may speculate that [ 18 F]PSMA-1007 non-metastatic bone uptake could be secondary to underlying osteoporosis. This hypothesis needs to be further investigated in larger populations and exploring more speci c markers of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The potential role of osteoporosis in unspecific [18F]PSMA-1007 bone uptake

Ninatti,

Pini,

Gelardi

et al. 2023

Eur J Nucl Med Mol Imaging

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“…Approximately one-third of postmenopausal women aged > 50 years are affected by OP. As the population ages, the incidence of osteoporotic fractures increases [19]. Growing evidence has suggested that systematic diseases such as diabetes and rheumatic inflammatory diseases are strongly associated with the development of OP [20,21].…”

Section: Oxidative Stress In Menopausal Women Elderly Patients and Di...mentioning

confidence: 99%

Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration

Li¹,

Li²

2022

Pharmaceuticals

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Gastrodin, a traditional Chinese medicine ingredient, is widely used to treat vascular and neurological diseases. However, recently, an increasing number of studies have shown that gastrodin has anti-osteoporosis effects, and its mechanisms of action include its antioxidant effect, anti-inflammatory effect, and anti-apoptotic effect. In addition, gastrodin has many unique advantages in promoting bone healing in tissue engineering, such as inducing high hydrophilicity in the material surface, its anti-inflammatory effect, and pro-vascular regeneration. Therefore, this paper summarized the effects and mechanisms of gastrodin on osteoporosis and bone regeneration in the current research. Here we propose an assumption that the use of gastrodin in the surface loading of oral implants may greatly promote the osseointegration of implants and increase the success rate of implants. In addition, we speculated on the potential mechanisms of gastrodin against osteoporosis, by affecting actin filament polymerization, renin–angiotensin system (RAS) and ferroptosis, and proposed that the potential combination of gastrodin with Mg2+, angiotensin type 2 receptor blockers or artemisinin may greatly inhibit osteoporosis. The purpose of this review is to provide a reference for more in-depth research and application of gastrodin in the treatment of osteoporosis and implant osseointegration in the future.

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“…Bone marrow mesenchymal stem cells (BMSCs) are non-hematopoietic stem cells and progenitor cells that have the potential to differentiate into various cell types, including osteoblasts, adipocytes, and chondrocytes ( 1 , 2 ). BMSCs are characterized by their abundance, high capacity for self-renewal, pluripotency, weak immunogenicity, and ease of transfection ( 3 ), which makes them as an ideal source of stem cells for transplantation and they are broadly used for the treatment of bone-related diseases ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Andrographis paniculata ameliorates estrogen deficiency-related osteoporosis by directing bone marrow mesenchymal stem cell fate

Song¹,

Zhou²,

Du³

et al. 2023

Ann Transl Med

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Background Although Andrographis paniculata (AP) exhibits various biological functions such as anticancer, anti-inflammatory, antimalarial, antimicrobial, antioxidant, cardioprotective and immunomodulatory, its role in estrogen deficiency-related osteoporosis remains unclear. Methods Ovariectomy (OVX)-induced estrogen deficiency-related osteoporotic mouse models and sham mouse models were established using 8-week-old female C57BL/6J mice. Micro-computed tomography (µCT) scanning was performed to assess the skeletal phenotype. The differentiation potential of bone marrow mesenchymal stem cells (BMSCs) from the OVX and sham groups was assessed by osteogenic or adipogenic induction medium in vitro . To verify the effects of AP, alizarin red S (ARS) staining, alkaline phosphatase (ALP) staining and oil red O (ORO) staining, reverse transcription assay and quantitative real-time polymerase chain reaction were applied to detect the lineage differentiation ability of BMSCs. Results µCT scanning showed that AP treatment attenuated the osteoporotic phenotype in OVX-induced estrogen deficiency-related osteoporotic mice. The results of ARS staining, ALP staining, ORO staining and quantitative real-time polymerase chain reaction indicated that BMSCs from OVX-induced osteoporotic mice displayed a significant reduction in osteogenic differentiation and an increase in adipogenic differentiation, which could be reversed by AP treatment. Conclusions Our findings suggested that AP regulated the differentiation potential of BMSCs and ameliorated the development of estrogen deficiency-related osteoporosis, which might be an effective therapeutic method for estrogen deficiency-related osteoporosis.

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Relationship between indices of circulating blood cells and bone homeostasis in osteoporosis

Cited by 6 publications

References 55 publications

The potential role of osteoporosis in unspecific [18F]PSMA-1007 bone uptake

The potential role of osteoporosis in unspecific [18F]PSMA-1007 bone uptake

Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration

Andrographis paniculata ameliorates estrogen deficiency-related osteoporosis by directing bone marrow mesenchymal stem cell fate

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