Relationship between increased systemic immune-inflammation index and coronary slow flow phenomenon

Abstract

Background Systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio), a new marker of inflammation, is associated with adverse cardiovascular events, but its relationship with coronary slow flow phenomenon (CSFP) is unclear. Therefore, we aimed to investigate the relationship between SII and CSFP. Methods We enrolled consecutive patients who presented with chest pain, with normal/near-normal coronary angiography findings (n = 89 as CSFP group; n = 167 as control group). The baseline characteristics, laboratory parameters and angiographic characteristics of the two groups were compared. Results SII levels were significantly higher in the CSFP group than in the control group (409.7 ± 17.7 vs. 396.7 ± 12.7, p < 0.001). A significant positive correlation between SII and the mean thrombolysis in myocardial infarction frame count (mTFC) was found (r = 0.624, p < 0.001). SII increased with the number of coronary arteries involved in CSFP. In multivariate logistic regression analysis, SII/10 was an independent predictor of CSFP (odds ratio: 1.739, p < 0.001). In addition, the SII level > 404.29 was a predictor of CSFP with 67.4% sensitivity and 71.9% specificity. Conclusions SII can predict the occurrence of CSFP.

Analysis of correlative factors of female coronary slow-flow phenomenon: A retrospective study

“…[14] Diabetes and smoking were identified as independent risk factors for cardiovascular disease, whereas disorders in lipid metabolism independently predicted the risk of atherosclerotic cardiovascular disease. [15] Our study revealed a higher prevalence of smoking and an increased incidence of diabetes among female patients with CSFP, which is consistent with the findings in male patients and previous studies.…”

Comparison of Systemic Immune-Inflammation Index and Naples Prognostic Score for Prediction Coronary Artery Severity Patients Undergoing Coronary Computed Tomographic Angiography

“…38-40 It has been linked to pathologies that may result in serious cardiac adverse events such as an ectatic coronary artery, slow flow phenomenon, and microvascular dysfunction. 41-43 Recent studies have found that SII is a reliable predictor of the severity of CAD and poor long-term prognosis in patients with acute coronary syndrome. 9-44 It is also an independent predictor of hospitalization, non-fatal MI, ischemic stroke, and death in CV diseases.…”

Evaluation of systemic immune-inflammation index efficacy in predicting complicated appendicitis in pediatric emergency department

“…It has also appeared to be associated with poor outcomes in many different clinical conditions, including cardiovascular disease and autoimmune disorders. [ 15 - 19 ] However, studies evaluating the usability of SII in pediatric patients are limited. [ 47 - 49 ] In our study, a cut-off value of 923 (sensitivity 78.30% and specificity 95.33%) was found for SII to diagnose AA.…”

“…[ 12 - 14 ] It has also been reported that in addition to oncological diseases, SII can be used to predict prognosis in coronary artery disease, infective endocarditis, rheumatological diseases, and COVID-19 disease, as well as to evaluate disease activity in inflammatory bowel diseases. [ 15 - 22 ]…”