Relationship between impulsive sensation seeking traits, smoking, alcohol and caffeine intake, and Parkinson's disease

Evans, Andrew; Lawrence, Andrew David; Potts, Jim; MacGregor, Lachlan; Katzenschlager, Regina; Shaw, Karen; Zijlmans, J.C.M.; Lees, Andrew J.

doi:10.1136/jnnp.2005.065417

Cited by 177 publications

(134 citation statements)

References 40 publications

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“…A study conducted in Singapore reported an inverse association between alcohol intake as a continuous variable and PD (p value 0.001) [358]. Two studies reported decreasing risk of PD with increasing amount of alcohol intake, although comparisons between categories of alcohol intake were generally non-significant [417,458]. One relatively large (342 cases) German study observed risk estimates below unity for beer and spirits, but not for wine [458].…”

Section: Case-control Studiesmentioning

confidence: 99%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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Section: Case-control Studiesmentioning

confidence: 99%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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“…Both associations might be correct and are consistent with a unifying explanation involving contrasting behavioural characteristics of the two conditions: ie, patients with Parkinson's disease may lead a conservative lifestyle Á avoiding smoking, alcohol, coffee etc. [23 Á 26] Á while those with MS may do the opposite Á that is they have 'impulsive seeking traits' leading to health adverse conduct [26,27]. This proposition could be tested by a case-control questionnaire or, better still, by a prospective cohort study.…”

Section: Combinedmentioning

confidence: 99%

Smoking is a risk factor for multiple sclerosis: a metanalysis

Hawkes¹

2007

Mult Scler

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Several case control studies have probed a link between cigarette smoking and subsequent multiple sclerosis (MS). Data collection and statistical methods have varied, and frequently, case numbers have been small. Publications relating to MS and smoking are reviewed and combined where comparable methods have been used. Metanalysis of six informative studies show significantly elevated odds or rate ratios, ranging from 1.22 to 1.51, depending on the method of analysis, confirming that the risk of MS is increased for those who smoke prior to disease onset, as measured by commencement of symptoms. A variety of direct causative mechanisms are discussed, but an indirect association through health adverse conduct is favoured. Multiple Sclerosis 2007; 13: 610 Á 615.

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“…brza vožnja automobila ili ekstremni sportovi) [3,16]. Pobrojane karakteristike su inače suprotne klasičnom, anhedoničnom profilu ličnosti koji je označen kao dominantan kod oboljelih od Parkinsonove bolesti, s obzirom na manju učestalost pušenja, upotrebe alkohola ili kafe od učestalosti ovih pojava u opštoj populaciji [25]. Konačno, moguće je da i kulturološke osobenosti i različite socijalne norme imaju značajan uticaj na učestalost patološkog kockanja, s obzirom da je prevalencija ovog poremećaja značajno manja kod oboljelih od Parkinsonove bolesti u Kini i Koreji (0,32% i 1,3%) [26,27], zemljama u kojima su mogućnosti za kockanje limitirane.…”

Section: Učestalost I Faktori Rizikaunclassified

Поремећај Контроле Импулса И Облици Репетитивног Понашања У Паркинсоновој Болести

Петровић¹,

Митровић²,

Петровић³

et al. 2011

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Kratak sadržajDopamin je jedan od ključnih neurotransmitera u mozgu čiji poremećaj funkcije dovodi do brojnih neuroloških i psihijatrijskih poremećaja. Parkinsonova bolest predstavlja prototip poremećaja motorike, ponašanja i pamćenja u čijoj osnovi se nalazi poremećaj funkcije dopamina. Antiparkinsona terapija dovodi do značajnog poboljšanja motornih poremećaja, ali istovremeno može biti uzrok čitavog spektra nemotornih ispoljavanja i dezinhibisanog ponašanja čija je osnova karakteristika repetitivno ponavljanje obrazaca ponašanja sa brojnim štetnim posljedicama. U psihopatološka ispoljavanja povezana sa aberantnom stimulacijom dopaminskih receptora ubrajaju se poremećaj kontrole impulsa, sindrom dopaminergičke disregulacije i poseban oblik repetitivnog ponašanja označen kao punding. U ovom pregledu literature fokusiraćemo se na fenomenologiju i epidemiologiju ovih ispoljavanja, kao i na mogućnosti njihovog dijagnostikovanja. U skladu sa do sada poznatim činjenicama, kod oboljelih od Parkinsonove bolesti, kao i brojnih eksperimentalnih modela, osvrnućemo se na aktuelni stav o ulozi bazalnih ganglija u regulaciji motorike i ponašanja. Konačno, shodno pretpostavljenom neurobiološkom supstratu razmotrićemo i mogući racionalan terapijski pristup ovim poremećajima.Ključne riječi: Parkinsonova bolest, poremećaj kontrole impulsa, sindrom dopaminergičke disregulacije, punding, terapija Uvod Dopaminergički sistem mozga jedan je od osnovnih neurotransmiterskih sistema koji učestvuju u regulaciji procesa motornog i nemotornog učenja neophodnih za efikasno odvijanje motorike, svrsishodnog ponašanja, donošenja odluka i regulacije prirodnih nagona [1].Parkinsonova bolest je neurodegenerativna bolest koja nastaje usljed progresivnog odumiranja dopaminergičkih neurona supstancije nigre pars compacta (SNpc) i posljedičnog deficita dopamina u predjelu strijatuma. Širok spek-

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Relationship between impulsive sensation seeking traits, smoking, alcohol and caffeine intake, and Parkinson's disease

Abstract: This study raises the possibility that there is a neurobiological link between low sensation seeking traits--which might underlie the parkinsonian personality--and the hypothetical protective effect of cigarette smoking and caffeine consumption on PD.

Cited by 177 publications

References 40 publications

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Smoking is a risk factor for multiple sclerosis: a metanalysis

Поремећај Контроле Импулса И Облици Репетитивног Понашања У Паркинсоновој Болести

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