Relationship between immunological parameters and survival of patients with liver metastases from breast cancer given immuno-chemotherapy

Yamasaki, Seiji; Kan, Norimichi; Harada, Tomohiro; Ichinose, You; Moriguchi, Yoshio; Li, Li; Sugie, Tomoharu; Kodama, Hiroshi; Satoh, Kasumi; Ohgaki, K

doi:10.1007/bf00682700

Cited by 16 publications

(12 citation statements)

References 16 publications

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“…NK cells are considered to be the most active component of the anti-tumor response (Ader et al, 1991;Garssen and Goodkin, 1999), (Mackay et al, 1983). However, other studies have found either no such relationship (Levy et al, 1991) or in a similar way to the present study, have reported that high NKA predicts shorter survival time (Yamasaki et al, 1993). While NK cells and NKA assays appeared to be relevant markers of tumor immunology 10-15 years ago, the empirical evidence from prospective studies is very weak.…”

Section: Discussionsupporting

confidence: 43%

“…The strengths of the present study include sampling of a homogenous sample of subjects on a consecutive admission basis, consideration of known clinical prognostic variables in analyses and the comprehensiveness of the immune and psychosocial measures. While the number of individual parameters measured and the associated costs in this study precluded inclusion of a larger number of subjects, the sample size is comparable to previous studies (30-81 subjects) of the influence of NKA or PNI on survival in breast cancer (Levy et al, 1991;Mackay et al, 1983;Yamasaki et al, 1993) or other cancer patients (Fawzy et al, 1993). For the present study, we had only sufficient power to detect large hazards ratios.…”

Section: Discussionmentioning

confidence: 60%

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Immune function and adjustment style: Do they predict survival in breast cancer?

et al. 2003

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The aim of this study was to investigate the role of immune status and psychosocial factors in survival from early breast cancer (N=61). Baseline assessments included lymphocyte number and function, natural killer cell activity (NKA), plasma cortisol and prolactin level. Psychosocial measures included anxiety, depression and mental adjustment to cancer and social support. Length of follow-up was 6.1-7.9 years with 14 (23%) breast cancer deaths. In Cox proportional hazards models adjusting for lymph node status two parameters predicted longer survival, low NKA (HR 29 per LLU, p=0.003) and minimizing the illness adjustment (HR 0.64 per scale point, p=0.012). These data provide little evidence for a psychoneuroimmunological mechanism in the survival from breast cancer. While this study is limited due to small sample size, and therefore the possibility of inflated estimates, longer survival in those minimizing the illness is a finding consistent with recent studies; however, the counter-intuitive finding that high NKA predicts shorter survival may be a marker for current disease or response to treatments.

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Section: Discussionsupporting

confidence: 43%

Section: Discussionmentioning

confidence: 60%

Immune function and adjustment style: Do they predict survival in breast cancer?

et al. 2003

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“…In a study of ovarian cancer patients, greater levels of distress were associated with reduced natural killer cell cytotoxicity (NKCC) in peripheral blood and also NKCC in the tumor microenvironment (Lutgendorf et al, 2005). Breast cancer patients show significantly lower NKCC compared to healthy controls, even among Stage I–III patients, and NKCC appears to be even lower in Stage IV patients (Baxevanis et al, 1993; Konjevic & Spuzic, 1993) and in those with liver metastases (Yamasaki et al, 1993). Among patients with solid tumors, higher NKCC predicted longer survival time without metastases over a 13-year period (Pross & Baines, 1988).…”

Section: Stress Influences On Cancer Relevant Biological Processesmentioning

confidence: 99%

Psychological intervention and health outcomes among women treated for breast cancer: A review of stress pathways and biological mediators

McGregor

Antoni

2009

Brain, Behavior, and Immunity

207

162

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Breast cancer is a common cancer among American women. The diagnosis, treatment, and the challenges of survivorship all have potential to increase women's levels of distress to levels that might influence their adaptation and possibly the course of disease. Psychological distress can influence tumor progression via many different pathways (e.g., genetic changes, immune surveillance, pro-angiogenic processes). Psychological intervention has been shown to facilitate psychological adaptation to breast cancer. But can psychological intervention influence cancer relevant biological outcomes among breast cancer survivors? We review the literature on how psychological intervention can influence cancer-relevant biological outcomes among breast cancer patients. We limited the present review to randomized controlled trials reported in the past 6 years that tested the effects of psychological intervention on biological dependent variables among patients with non-metatstic breast cancer. There are data to suggest that psychological intervention can influence neuroendocrine (e.g. cortisol) and immune function indicators, especially lymphocyte proliferation and TH1 cytokine production. Future psychological intervention studies should also focus on more newly discovered stress-tumor pathways (e.g., neuroendocrine processes promoting tumor growth and metastasis) and follow larger cohorts of the most vulnerable patients over longer periods to evaluate the lasting effects of these interventions on health and quality of life and their underlying biobehavioral mechanisms.

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“…T-cell proliferative response has been correlated with breast cancer recurrence [36] and survival [21,37]. LPR to phytohemagluttinin (PHA) and concanavalin A (Con A) was determined, as described [5,32].…”

Section: Lymphocyte Proliferative Response (Lpr)mentioning

confidence: 99%

Immune, endocrine, and behavioral precursors to breast cancer recurrence: a case-control analysis

Thornton

Andersen

Carson

2008

Cancer Immunol Immunother

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Relationship between immunological parameters and survival of patients with liver metastases from breast cancer given immuno-chemotherapy

Cited by 16 publications

References 16 publications

Immune function and adjustment style: Do they predict survival in breast cancer?

Immune function and adjustment style: Do they predict survival in breast cancer?

Psychological intervention and health outcomes among women treated for breast cancer: A review of stress pathways and biological mediators

Immune, endocrine, and behavioral precursors to breast cancer recurrence: a case-control analysis

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