Relationship Between IL-10 Gene Polymorphism and Spinal Tuberculosis

Ma, Jinming; Lv, Zhongzhe; Wang, Jianchuan; Lu, Jianrong

doi:10.12659/msm.914039

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…ST is the most common type of bone and joint TB. M.tb in the primary focus of ST as it can spread directly to the edge of the vertebral body through blood and lymphatic vessels ( 15 , 16 ), causing destruction of the vertebral body or intervertebral disc, spinal deformities, dysfunction, paraplegia and death, particularly in certain severe cases ( 4 , 17 ). The immune response of M.tb infection is mainly cell-mediated immune response, during which specific Th1 cells are sensitized with the M.tb antigen to produce IFN-γ.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of CXCR3 and its ligands in spinal tuberculosis

et al. 2020

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The present study aimed to investigate whether C-X-C motif chemokine receptor 3 (CXCR3) and its ligands may aid in diagnosing spinal tuberculosis (ST). A total of 36 patients with ST and 20 healthy controls were enrolled in the present study. The morphology of tuberculous granuloma in spinal tissue was observed by hematoxylin and eosin staining. The presence and distribution of acid-fast bacilli (AFB) were observed by Ziehl-Neelsen (ZN) staining. The protein expression of Ag85B, IFN-γ, and CXCR3 and its ligands (CXCL9 and CXCL10) were detected by immunohistochemistry. The levels of IFN-γ, CXCR3, CXCL9 and CXCL10 in peripheral blood of patients with ST and healthy controls were detected by reverse transcription-quantitative polymerase chain reaction and ELISA. Typical tuberculous granuloma was observed in the ST close tissue. AFB was observed by ZN staining. Positive expression of Ag85B was found in the surrounding caseous necrotic tissue of the tuberculous granuloma. IFN-γ, CXCR3, CXCL9 and CXCL10 were expressed in the tissue surrounding the tuberculous granuloma and their expression levels were markedly higher than those in the distant tissues. The levels of IFN-γ, CXCR3, CXCL9 and CXCL10 in peripheral blood of patients with ST were significantly higher than those in the healthy controls. Receiver operating characteristic curve analysis demonstrated that IFN-γ, CXCR3 and CXCL10 were more reliable diagnostic markers in terms of sensitivity and specificity. IFN-γ, CXCR3, CXCL9 and CXCL10 were highly expressed in the lesion tissue and peripheral blood samples of patients with ST, and IFN-γ, CXCR3 and its ligands aided in diagnosing ST.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of CXCR3 and its ligands in spinal tuberculosis

et al. 2020

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“…After an early stage of inadequate control, Mycobacterium tuberculosis infection often reaches a state of equilibrium characterized by immune control and bacterial persistence ( Chandra et al., 2022 ). It has been discovered that inflammation-associated cytokines play a crucial role in the progression of inflammation while Mycobacterium tuberculosis infects the host ( Ma et al., 2019 ). Interleukin-10 (IL-10) plays a role in reducing the inflammatory response by interacting with other inflammatory factors, thereby impacting the progression of spinal tuberculosis ( Liu et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

IL-10 and TGF-β1 may weaken the efficacy of preoperative anti-tuberculosis therapy in older patients with spinal tuberculosis

Li,

Wu,

Feng

et al. 2024

Front. Cell. Infect. Microbiol.

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Spinal tuberculosis is a common extrapulmonary type that is often secondary to pulmonary or systemic infections. Mycobacterium tuberculosis infection often leads to the balance of immune control and bacterial persistence. In this study, 64 patients were enrolled and the clinicopathological and immunological characteristics of different age groups were analyzed. Anatomically, spinal tuberculosis in each group mostly occurred in the thoracic and lumbar vertebrae. Imaging before preoperative anti-tuberculosis therapy showed that the proportion of abscesses in the older group was significantly lower than that in the younger and middle-aged groups. However, pathological examination of surgical specimens showed that the proportion of abscesses in the older group was significantly higher than that in the other groups, and there was no difference in the granulomatous inflammation, caseous necrosis, inflammatory necrosis, acute inflammation, exudation, granulation tissue formation, and fibrous tissue hyperplasia. B cell number was significantly lower in the middle-aged and older groups compared to the younger group, while the number of T cells, CD4+ T cells, CD8+ T cells, macrophages, lymphocytes, plasma cells, and NK cells did not differ. Meaningfully, we found that the proportion of IL-10 high expression and TGF-β1 positive in the older group was significantly higher than that in the younger group. TNF-α, CD66b, IFN-γ, and IL-6 expressions were not different among the three groups. In conclusion, there are some differences in imaging, pathological, and immune features of spinal tuberculosis in different age groups. The high expression of IL-10 and TGF-β1 in older patients may weaken their anti-tuberculosis immunity and treatment effectiveness.

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“…Some studies have shown that the levels of IL‐10 in TAK the active phase were lower than that in the stable phase 5 . The link between the IL‐10 gene polymorphism and certain disorders has been investigated, such as type 2 diabetes mellitus, 6 diabetic retinopathy, 7 Alzheimer's disease, 8 spinal tuberculosis, 9 psoriasis 10 . However, there are limitations for individual studies.…”

Section: Introductionmentioning

confidence: 99%

Systemic review and meta‐analysis of the association between interleukin‐10 and Takayasu arteritis

Zhou

Liang

et al. 2023

Int J of Rheum Dis

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Takayasu arteritis (TAK) is a chronic, large-vessel systemic vasculitis, 1 which affects large arteries, such as the aorta and its major branches and the pulmonary arteries. TAK mainly occurs in young adults, and may even affect children. 2 This disease occurs in both genders, but is more common in women during the second and third decades. TAK is distributed globally, with a greater prevalence in Asia. The variation in incidence and age of diagnosis among different ethnic groups is considerable. 3 In the acute phase of TAK, intima thickens with fibroblasts due to inflammation and mucopolysaccharide deposition. In the chronic phase, vascular fibrosis, vascular stenosis and occlusion, aneurysmal dilation occur in the aorta and major branches, which leads to hypertension, renal artery stenosis, pulmonary hypertension and congestive heart failure. 3 Interleukin (IL)-10 is a prototypical anti-inflammatory cytokine which plays a role in the maintenance and restoration of immunological homeostasis. Also, it can enhance the immune responses. 4

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Relationship Between IL-10 Gene Polymorphism and Spinal Tuberculosis

Cited by 9 publications

References 19 publications

Diagnostic value of CXCR3 and its ligands in spinal tuberculosis

Diagnostic value of CXCR3 and its ligands in spinal tuberculosis

IL-10 and TGF-β1 may weaken the efficacy of preoperative anti-tuberculosis therapy in older patients with spinal tuberculosis

Systemic review and meta‐analysis of the association between interleukin‐10 and Takayasu arteritis

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