Relationship between Hyperuricemia and Body Fat Distribution

Abstract

Objective We investigated the relationship between serum uric acid (SUA)

Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

“…Numerous epidemiological studies have shown a positive correlation between body weight and serum uric acid levels (31,32). Recently, it was reported in a cross-sectional study that serum uric acid levels were associated with visceral fat accumulation (33). Compared with previous studies, the follow-ing features are unique to the present study; 1) inclusion of a large number (1,520 (34,35), and that hyperinsulinemia associated with visceral fat obesity may reduce urinary urate excretion in parallel with a decrease in urinary sodium excretion (36).…”

Uric Acid Secretion from Adipose Tissue and Its Increase in Obesity

“…In humans, uric acid is the final oxidation product of purine catabolism (1). Elevated serum uric acid (hyperuricemia) is closely associated with visceral fat accumulation (2)(3)(4) and various metabolic disorders, such as glucose intolerance, elevated blood pressure, dyslipidemia, and atherosclerotic cardiovascular diseases, conceptualized as metabolic syndrome (5)(6)(7)(8)(9)(10). The level of serum uric acid is determined by a balance between purine dietary uptake and production and excretion of uric acid.…”

“…Xanthine oxidoreductase (XOR) 2 is an enzyme known to catalyze purines, such as xanthine and hypoxanthine, to uric acid. XOR is also a pharmacological target of the antihyperuricemic agents allopurinol and febuxostat.…”

Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis

“…13) Hyperuricemia is also linked to metabolic syndromes or renal disorders. 14,15) Epidemiological studies have shown an increasing incidence of gout and hyperuricemia, diseases which are common to men. 16,17) The prevalence of gout and hyperuricemia in Japanese males 18) and males in other countries 17,19) is about 1-2% and 10-25%, respectively.…”