Relationship between hydrogen ion concentration and flow of gastric juice during inhibition of gastric secretion in the cat.

Hirst, Barry H.; Labib, L A; Reed, J. D.; Stephen, J. G.

doi:10.1113/jphysiol.1980.sp013385

Cited by 4 publications

(11 citation statements)

References 19 publications

(12 reference statements)

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“…In a previous study, we have shown that this relationship between [H+] and flow of gastric juice is similar during stimulation of gastric secretion by pentagastrin, histamine and insulin (Hirst, Labib, Reed & Stephen, 1980). Moreover, the relationship is not altered during inhibition of gastric secretion by histamine H2-receptor antagonists, anticholinergics or somatostatin.…”

Section: Introductionmentioning

confidence: 76%

“…The calculated non-parietal volumes from data during stimulation with pentagastrin, insulin or histamine agree closely with the observed volume of unstimulated gastric secretion which contains very little H+ (Table 1). In addition, substances which have been shown not to affect the relationship between [H+] and gastric flow (Hirst et al 1980) do not alter the calculated non-parietal volume (Table 1 and Fig. 7).…”

Section: (B) Prostaglandinsmentioning

confidence: 85%

“…The normal relationship between [H+] and gastric flow during stimulation with pentagastrin was determined as described in detail previously, and is the same data as presented in Fig. 1 of Hirst et al (1980) PGE2,16, PGF2a were determined during the formation of a dose-response curve to pentagastrin by the continuous infusion method; pentagastrin, 1 jug kg-' h-1, was infused for 0 75 h and thereafter the dose of pentagastrin was doubled every half hour up to a maximum of 16 jug kg-' h-1 (Hirst, Labib & Reed, 1978 Hirst et al (1980), Fig. 1A.…”

Section: Analyses Of Resultsmentioning

confidence: 99%

“…First, we studied the effects of three inhibitors of gastric acid secretion which have been shown not to alter the normal relationship between [H+] and gastric flow, viz. cimetidine, atropine and somatostatin (Hirst et al 1980). Secondly, we investigated the effects of prostaglandins which in the present study were shown to alter the relationship between [H+] and flow (Figs.…”

mentioning

confidence: 90%

“…1-5). (a) Cimetidine, atropine and somatostatin Full details of the experiments with cimetidine, atropine and somatostatin are described elsewhere (Hirst et al 1980). The doses of these three antagonists produced significant inhibition of acid secretion.…”

mentioning

confidence: 99%

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Prostaglandins alter the relationship between gastric hydrogen ion concentration and flow: evidence for stimulation of non‐parietal secretion in the cat

Gascoigne

Hirst

1981

The Journal of Physiology

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SUMMARY1. The effect of i.v. administration of prostaglandin (PG) E2 (10-40 jug kg-' h-'), 16,16-dimethyl PGE2 (0-1-0-5 jag kg-h-'), PGE, (16)(17)(18)(19)(20) jg kg-h-1), PGA, (5-11 #ug kg-' h-') and PGF2a (40 , 3. At the dose tested, PGF2a had little effect on acid output, and did not alter the relationship between [H+] and gastric flow.4. There is a linear relationship between acid output and gastric flow and this relationship is similar during stimulation of gastric secretion by pentagastrin, histamine or insulin. Gastric acid inhibitory doses of cimetidine, atropine and somatostatin did not alter this relationship. In contrast the A-and E-type prostaglandins displaced this relationship to the right of the normal line observed with the acid stimulants alone. A-and E-type prostaglandins reduced the slope of the line relating acid output and gastric flow from -150-170 ,uequiv/ml-1 to 100-120 #equiv ml-', this being taken as evidence of dilution of the parietal H+ secretion with a non-parietal secretion.5. The volume of non-parietal gastric secretion was calculated as the gastric flow at zero acid output by extrapolation of linear plots of acid output versus gastric flow. Unstimulated gastric flow measured directly was 0 75 ml 15 min'. The calculated non-parietal flow was in the range 0-52-0 90 ml 15 min' during stimulation of gastric secretion with pentagastrin, histamine and insulin, and inhibition of pentagastrinstimulated acid secretion with cimetidine, atropine and somatostatin. PGE2 (1-51 ml 15 min-') and 16,16-dimethyl PGE2 (1-20 ml 15 min') nearly doubled the calculated non-parietal flow.

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Section: Introductionmentioning

confidence: 76%

Section: (B) Prostaglandinsmentioning

confidence: 85%

Section: Analyses Of Resultsmentioning

confidence: 99%

mentioning

confidence: 90%

mentioning

confidence: 99%

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Prostaglandins alter the relationship between gastric hydrogen ion concentration and flow: evidence for stimulation of non‐parietal secretion in the cat

Gascoigne

Hirst

1981

The Journal of Physiology

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The Gastric Mucosal Barrier

Hirst

1989

Comprehensive Physiology

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The effect of prostaglandins on gastric parietal and non-parietal secretion in the anaesthetized rat

1987

Journal of Pharmacy and Pharmacology

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The effects of prostaglandin E2 (PGE2), 16,16-dimethyl prostaglandin E2 (dmPGE2) and prostaglandin F2 alpha (PGF2 alpha) on gastric secretion have been examined in the anaesthetized rat. The prostaglandins stimulated the secretion of a non-parietal juice which was rich in Na+ and Cl- with smaller amounts of K+ and HCO3-. Doses of the prostaglandins that stimulated gastric non-parietal secretion also inhibited histamine stimulated gastric acid secretion, and thus the same rank order of potency was obtained for the prostaglandins on the two secretory mechanisms, viz. dmPGE2 greater than PGE2 greater than PGF2 alpha. During the secretion of endogenous gastric acid the secretagogue effect of the prostaglandins on non-parietal secretion was diminished, and this effect appeared to be due to the presence of intraluminal acid since it was mimicked by application of exogenous HCl to the gastric mucosal surface. Thus, the present results show that prostaglandins affect both the parietal and non-parietal secretions in the rat stomach and that these mechanisms show some interdependence.

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Relationship between hydrogen ion concentration and flow of gastric juice during inhibition of gastric secretion in the cat.

Cited by 4 publications

References 19 publications

Prostaglandins alter the relationship between gastric hydrogen ion concentration and flow: evidence for stimulation of non‐parietal secretion in the cat

Prostaglandins alter the relationship between gastric hydrogen ion concentration and flow: evidence for stimulation of non‐parietal secretion in the cat

The Gastric Mucosal Barrier

The effect of prostaglandins on gastric parietal and non-parietal secretion in the anaesthetized rat

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