Relationship between Humoral Immunoaugmenting Properties of DHEAS and IgD‐Receptor Expression in Young and Aged Mice<sup>a</sup>

Swenson, Christina D.; Gottesman, Susan; Belsito, D.; Samanich, Karen M.; Edington, Joanne; Thorbecke, G. J.

doi:10.1111/j.1749-6632.1995.tb17385.x-i1

Cited by 11 publications

(1 citation statement)

References 28 publications

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“…Up-regulation of T cell IgD receptor is associated with an increase of all immunoglobulin phenotypes except IgD. Swenson showed that the in vivo administration of DHEAS caused enhanced antibody formation in young and old mice [72].…”

Section: Studies Of Dhea(s) In Models Of Atopymentioning

confidence: 98%

Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders

Dillon

2005

CDTIA

106

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Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are metabolic intermediates in the production of potent androgens, estrogens and other less well-characterized steroids. DHEA(S) and closely related steroid hormones have a variety of immunological effects both in vitro and in vivo in experimental animals and humans. Many of these effects have been demonstrated in animal models where there is little circulating DHEA(S), and the demonstrated effects are generally seen at concentrations of DHEA(S) which are supra-physiological in man. The physiological role of DHEA(S) in the immunological system is unknown. Furthermore, the molecular mechanism of action of DHEA(S) is unclear. In this review, I focus on studies of the immunological effects of DHEA(S) and closely related steroid metabolites and analogs, mainly derived from literature published in the last five years. My purpose is to describe the demonstrated effects and to highlight some of the remaining major research issues in this field. These issues include defining the molecular mechanism of DHEA(S) action; determining whether the effect of DHEA(S) is related to the steroid itself or to a metabolic product of DHEA; determining the relationship of physiological function to the pharmacological effects; and determining the molecular basis for species-specific differences in effects.

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Section: Studies Of Dhea(s) In Models Of Atopymentioning

confidence: 98%

Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders

Dillon

2005

CDTIA

106

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Immunology of Aging

Burns¹,

Goodwin²

Geriatric Medicine

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Effects of Aging on Immune Function

Burns

Goodwin²

2011

Principles and Practice of Geriatric Surgery

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Relationship between Humoral Immunoaugmenting Properties of DHEAS and IgD‐Receptor Expression in Young and Aged Mice^a

Cited by 11 publications

References 28 publications

Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders

Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders

Immunology of Aging

Effects of Aging on Immune Function

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Relationship between Humoral Immunoaugmenting Properties of DHEAS and IgD‐Receptor Expression in Young and Aged Micea

Cited by 11 publications

References 28 publications

Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders

Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders

Immunology of Aging

Effects of Aging on Immune Function

Contact Info

Product

Resources

About

Relationship between Humoral Immunoaugmenting Properties of DHEAS and IgD‐Receptor Expression in Young and Aged Mice^a