Relationship between homocysteine levels, anterior chamber depth, and pseudoexfoliation glaucoma in patients with pseudoexfoliation

Koç, Hacı; Kaya, Faruk

doi:10.1007/s10792-020-01341-4

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…Other hypothesized epigenetic risk factors to evaluate further include hypertension, elevated homocysteine levels, UV exposure and smoking. All of which can result in changes at the epigenetic level leading to disruption of gene expression, including LOXL1 and repair of essential ECM proteins (Altobelli et al, 2018;Aune et al, 2018;Bleich et al, 2004;Cao et al, 2014;Chan CYT & Cheng SWK, 2017;Hayat et al, 2020;Koc & Kaya, 2020;Krishna et al, 2013;Lonn et al, 2006;Mohod et al, 2014;Norman & Curci, 2013;Rebecca et al, 2019;Ritch, 2014;Zong et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Abdominal aortic aneurysm and exfoliation syndrome: A literature review comparing single site findings

Patil

Conley

Paulson

et al. 2022

Acta Ophthalmologica

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Several studies have suggested a possible relationship between exfoliation syndrome (XFS) and abdominal aortic aneurysm (AAA). A systematic literature review was undertaken to investigate this potential association. The systematic literature review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines. Clear definitions of XFS and AAA were used to identify eligible studies via an unrestricted search of the PubMed interface from 1979 to October 31st, 2021. After review, 876 citations were gathered and evaluated for inclusion, from which 22 articles were included. Of these 22, 16 were excluded because they did not assess the relationship between AAA and XFS or provide primary data. Ultimately, six studies were included in this literature review. Half of the studies explored AAA prevalence in a population with or without XFS, and the other half explored the opposite. Three studies supported XFS as a risk factor for the development of AAA, and the other three found this relationship to be inconclusive. This systematic review revealed inconsistent results regarding an association between AAA and XFS. A large database study including XFS and AAA patients would be useful in further determining if an association does in fact exist.

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Section: Discussionmentioning

confidence: 99%

Abdominal aortic aneurysm and exfoliation syndrome: A literature review comparing single site findings

Patil

Conley

Paulson

et al. 2022

Acta Ophthalmologica

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“…According to Rebecca et al hyperhomocysteinemia in XFS causes structural changes promoting elastin aggregation (Rebecca et al, 2019). Serine metabolism also intersects with the methionine cycle (Yang and Vousden, 2016), in which methionine synthase remethylates homocysteine in a vitamin B12-dependent reaction (Yang and Vousden, 2016;Koc and Kaya, 2020). It is suggested that the intake of vitamin B6 and vitamin B12 may reduce the risk of pseudoexfoliation glaucoma (Kang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Reveals Differences in Aqueous Humor Composition in Patients With and Without Pseudoexfoliation Syndrome

Dmuchowska

Pietrowska

Krasnicki

et al. 2021

Front. Mol. Biosci.

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Pseudoexfoliation syndrome (XFS) is stress- or inflammation-induced elastosis accompanied by excessive production of microfibrils and their deposition in the anterior segment of the eye. Approximately 60–70 million people are affected by XFS worldwide. It is a component of a systemic disorder, considered a major risk factor for accelerated cataract formation, cataract surgery complications and development of glaucoma, which untreated or inadequately treated may lead to blindness. Moreover, XFS has been associated with cardiovascular and cerebrovascular morbidity, dementia, sensorineural hearing loss and pelvic organ prolapse. The pathogenesis of XFS has not been fully elucidated yet. Aqueous humor (AH) is a transparent fluid filling the anterior and posterior chambers of the eye. Determination of AH metabolites that are characteristic for XFS may provide valuable information about the molecular background of this ocular disorder. The aim of this study was to compare the composition of AH in XFS and non-XFS patients undergoing cataract surgery. The AH samples from 34 patients (15 with XFS and 19 without) were analyzed using liquid chromatography coupled to a Quadrupole Time-of-Flight mass spectrometer (LC-QTOF-MS). The obtained metabolic fingerprints were analyzed using multivariate statistics. Eleven statistically significant metabolites were identified. Compared with the non-XFS group, the AH of patients with XFS contained significantly lower levels of amino acids and their derivatives, for example, arginine (−31%, VIP = 2.38) and homo-arginine (−19%, VIP = 1.38). Also, a decrease in the levels of two acylcarnitines, hydroxybutyrylcarnitine (−29%, VIP = 1.24) and decatrienoylcarnitine (−46%, VIP = 1.89), was observed. However, the level of indoleacetaldehyde in XFS patients was significantly higher (+96%, VIP = 2.64). Other significant metabolites were two well-recognized antioxidants, ascorbic acid (−33%, VIP = 2.11) and hydroxyanthranilic acid (−33%, VIP = 2.25), as well as S-adenosylmethionine, a compound with anti-inflammatory properties (−29%, VIP = 1.93). Metabolic pathway analysis demonstrated that the identified metabolites belonged to eight metabolic pathways, with cysteine and methionine metabolism as well as arginine and proline metabolism being the most frequently represented. XFS can be associated with enhanced oxidative stress and inflammation, as well as with the disturbances of cellular respiration and mitochondrial energy production. Implementation of non-targeted metabolomics provided a better insight into the still not fully understood pathogenesis of XFS.

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“…20 It also causes vascular damage and oxidative stress, thereby contributing to the development of exfoliation glaucoma and other systemic disorders. 21 Strength of the study: The strength of our study was that it was the first of its kind studying the influence of ethnic variation in Pakistani population on the risk of development of PEX. Other factors assessed had also not been previously studied in the Pakistani population.…”

Section: Discussionmentioning

confidence: 99%

The association between ethnicity, environmental and lifestyle factors and chronic disease in the development of pseudoexfoliation syndrome

Arif

Khan²,

Nauman³

et al. 2021

Pak J Med Sci

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Objectives: To determine the association between ethnicity, environmental factors, lifestyle factors, chronic diseases and pseudoexfoliation syndrome (PEX). Methods: A case control study conducted at four major hospitals in Pakistan from January to November 2019, with 241 cases and 294 controls, aged ≥ 40 years, who were administered a questionnaire assessing demographics, lifestyle factors, chronic diseases and ethnicity. Multivariate binary logistic regression was applied to calculate the odds ratio between cases and controls. Results: PEX was found to be positively associated with ethnicity (p<0.001), time spent outdoors (p<0.001), educational status (p<0.001), asthma (p<0.001), mean age (p<0.001), daily tea intake (p=0.003), weighted maximum temperature (p<0.001) and weighted mean temperature (p=0.004). Poor association was found with weighted latitude (p=0.526) and weighted minimum temperature (p=0.079). Odds ratios for patients with asthma (OR=7.366, regression coefficient=1.993, p<0.001) Pathan ethnicity (OR=1.616, regression coefficient=0.48, p=0.016) and mean weighted temperature (OR=0.907, regression coefficient-0.097, p=0 0.000) were significant in diagnosed cases of PEX. Conclusion: Individuals with Pathan ethnicity and asthmatics should be made aware of the risk of developing PEX and the importance of periodic screening. Limiting exposure to sunlight and cold and reducing the intake of tea may help in reducing in the chances of developing PEX. doi: https://doi.org/10.12669/pjms.37.2.2216 How to cite this:Arif SA, Khan MI, Nauman F, Arif MA. The association between ethnicity, environmental and lifestyle factors and chronic disease in the development of pseudoexfoliation syndrome. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.2216 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Relationship between homocysteine levels, anterior chamber depth, and pseudoexfoliation glaucoma in patients with pseudoexfoliation

Cited by 9 publications

References 28 publications

Abdominal aortic aneurysm and exfoliation syndrome: A literature review comparing single site findings

Abdominal aortic aneurysm and exfoliation syndrome: A literature review comparing single site findings

Metabolomics Reveals Differences in Aqueous Humor Composition in Patients With and Without Pseudoexfoliation Syndrome

The association between ethnicity, environmental and lifestyle factors and chronic disease in the development of pseudoexfoliation syndrome

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