Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection

Xu, Tao; Sun, Meiqun; Wang, Hongtao

doi:10.1155/2017/9679843

Cited by 17 publications

(14 citation statements)

References 22 publications

(40 reference statements)

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“…Vermehren et al (Vermehren et al, 2012) failed to confirm an association of HLA-DPB1 rs9277535 with hepatitis B in Caucasians. A comprehensive meta-analysis suggested that HLA-DP/DQ (rs3077, rs9277535, rs9275572, rs9275319, rs2856718, and rs7453920) is associated with susceptibility to HBV or the clearance of HBV infection (Zhang et al, 2013e; Yu et al, 2015; Xu et al, 2017b; Xu et al, 2018). A meta-analysis by Huang et al (Huang et al, 2016) suggested that HLA-DQB1*0201, DQB1*0301, and DQB1*0502 are associated with an increased risk of CHB (chronic hepatitis B), while HLA-DQB1*0303 and DQB1*0604 are associated with a decreased risk of CHB.…”

Section: Chronic Hbv Infectionmentioning

confidence: 99%

Host Genetic Determinants of Hepatitis B Virus Infection

et al. 2019

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Chronic hepatitis B virus (HBV) infection is still a major health problem worldwide. Recently, a great number of genetic studies based on single nucleotide polymorphisms (SNPs) and genome-wide association studies have been performed to search for host determinants of the development of chronic HBV infection, clinical outcomes, therapeutic efficacy, and responses to hepatitis B vaccines, with a focus on human leukocyte antigens (HLA), cytokine genes, and toll-like receptors. In addition to SNPs, gene insertions/deletions and copy number variants are associated with infection. However, conflicting results have been obtained. In the present review, we summarize the current state of research on host genetic factors and chronic HBV infection, its clinical type, therapies, and hepatitis B vaccine responses and classify published results according to their reliability. The potential roles of host genetic determinants of chronic HBV infection identified in these studies and their clinical significance are discussed. In particular, HLAs were relevant for HBV infection and pathogenesis. Finally, we highlight the need for additional studies with large sample sizes, well-matched study designs, appropriate statistical methods, and validation in multiple populations to improve the treatment of HBV infection.

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Section: Chronic Hbv Infectionmentioning

confidence: 99%

Host Genetic Determinants of Hepatitis B Virus Infection

et al. 2019

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“…Chang et al, who studied the effect of HLA variants and response to interferon therapy in male Han Taiwanese patients with CHB, concluded that "G-C" haplotype of the five SNPs, including rs9277535 (HLADPB1), rs9276370 (HLA-DQA2), rs7756516 and rs7453920 (HLA-DQB2), and rs9366816 near HLA-DPA3, is associated with sustained therapeutic response to IFN-α treatment [22]. In addition, results of a meta-analysis performed by Xu et al concluded that the HLA-DQ rs7453920-A allele was a protecting factor against chronic HBV infection, while rs 7453920-G serves as a risk factor for HBV infection [23].…”

Section: Discussionmentioning

confidence: 99%

Association between Human Leukocyte Antigen-DQ Polymorphisms and Treatment Response in Chronic Hepatitis B Egyptian Population: A Prospective Study

Mohamed¹,

Zaghloul²,

Attala³

et al. 2020

TOBIOMJ

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Background & Aims: Several studies, in different populations, have focused on the role of HLA-DQ gene polymorphism in the pathogenesis of HBV infection. However, these findings are still controversial. This study aimed to determine HLA-DQ polymorphism in Chronic HBV patients and its impact on the response to antiviral therapy. Methods: This study was carried out on a total number of 188 participants, they were subdivided as follows: Group I (patients’ group): included 97 patients with chronic hepatitis B viral infection that was further subdivided according to response to treatment into responder and non-responder subgroups, Group II (Control group): included 91 normal healthy subjects who were matched to the patient group by sex and age. PCR (Polymerase Chain Reaction) testing, for HBV-DNA, was done for all participants enrolled in the study to measure the viral virus load before and after treatment. HLA- DQ polymorphism allelic discrimination assay was assayed using the Real-time equipment. Results: In a general analysis for the SNP rs7453920, the overall genotypes frequencies were 37% for A/A, 60.6% for A/G, and 37% for G/G. The G alleles of HLA-DQ rs7453920 were significantly increased in chronic HBV infection patients. A total of 77 (79.4%) patients were responders. Among this group, 72.7% were male, and the average age was 38.59 ±9.15 years. On evaluation of the association between polymorphisms in HLA-DQ gene and treatment response, the results indicated that response to treatment declined when patients were carrying the more unfavorable rs 7453920 GG with a response rate of 64%. Patients carrying the mutant allele AG, or the wild type allele AA were more likely to achieve a higher rate of response (84.8% and 83.3%, respectively). Conclusion: The presence of HLA-DQB2 rs 7453920-G serves as a risk factor for chronic HBV infection and treatment failure in the Egyptian population.

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“…Compared to a single study, meta-analysis can provide sufficient results especially in analyzing unexplained studies [ 56 ]. In our previous meta-analysis including 11 case-control studies, we demonstrated that HLA-DQ rs2856718-G polymorphism showed protective effects against HBV infection, and rs2856718-A was a risk factor for chronic HBV infection [ 57 ]. Subsequently, Meta-analysis by Lv et al showed that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese other than in Saudi Arabian [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of HLA-DQ gene polymorphisms with the development of hepatitis B virus infection, clearance, liver cirrhosis, and hepatocellular carcinoma

Anyou

Sun

et al. 2017

Oncotarget

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Hepatitis B is one of the most common infectious diseases, which leads to public health problems in the world, especially in Asian counties. In recent years, extensive human genetic association studies have been carried out to identify susceptible genes and genetic polymorphisms to understand the genetic contributions to the disease progression of HBV infection. HLA-DQ gene variations have been reported to be associated with HBV infection/clearance, disease progression and the development of hepatitis B-related complications, including liver cirrhosis (LC) and hepatocellular carcinoma (HCC). However, the results are either inconclusive or controversial. Therefore, to derive a more precise estimation of the association, a meta-analysis was performed. Our data revealed that the HLA-DQ alleles rs2856718-G, rs7453920-A and rs9275319-G were significantly associated with decreased risk of HBV infection and HBV natural clearance. Logistic regression analyses showed that HLA-DQ alleles rs9275572-A significantly increased HBV infection clearance, and decreased HBV natural clearance. However, rs2856718-G and rs9275572-A were not associated with development of cirrhosis. The HLA-DQ polymorphisms (rs2856718 and rs9275572) were associated with a decreased HBV-related HCC risk in all genetic models, but rs9272105-A increased the risk of HBV-related HCC. In addition, no significant association was observed between HLA-DQ rs9275319-G polymorphism and HBV-related HCC. These stratified analyses were limited due to relatively modest size of correlational studies. In future, further investigation on a large population and different ethnicities are warranted. Our findings contribute to the personalized care and prognosis in hepatitis B.

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Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection

Cited by 17 publications

References 22 publications

Host Genetic Determinants of Hepatitis B Virus Infection

Host Genetic Determinants of Hepatitis B Virus Infection

Association between Human Leukocyte Antigen-DQ Polymorphisms and Treatment Response in Chronic Hepatitis B Egyptian Population: A Prospective Study

Quantitative assessment of HLA-DQ gene polymorphisms with the development of hepatitis B virus infection, clearance, liver cirrhosis, and hepatocellular carcinoma

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