Relationship between histomorphological findings and platelet activation in psoriasis

Abstract

Psoriasis is a chronic disease accompanied by local and systemic inflammation affecting approximately 2% of the population worldwide. 1 Psoriasis is assumed as a systemic condition rather than a disease limited to the skin due to systemic inflammation and accompanying comorbidities. 2 Platelets, which are known to have critical importance in systemic inflammatory pathways, are thought to play a role in the etiopathogenesis of psoriasis. 3 Platelet count (PC) is shown to increase significantly in patients with psoriasis. 4 In

Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases

“…Several studies reported a direct relationship between platelet activation and disease activity. 38,126 It has been recently shown that a P2Y12 inhibitor added to methotrexate improved RA disease severity. 127 It turns out that influencing platelet function can be key in improving clinical outcomes.…”

Evaluation of Platelet Parameters in Patients With Secondary Failure of Platelet Recovery and Cytomegalovirus Infection After Hematopoietic Stem Cell Transplantation

“…MPV is a measure of platelet size, which indirectly reflects the activity of platelets. 11 In coronary artery disease, preeclampsia and primary immune thrombocytopenia, an elevated MPV is a marker of platelet activation. 12–14…”

“…MPV is a measure of platelet size, which indirectly reflects the activity of platelets. 11 In coronary artery disease, preeclampsia and primary immune thrombocytopenia, an elevated MPV is a marker of platelet activation. [12][13][14] However, there are also articles reporting activated platelets leading to decreased MPV by secreting microvesiculation and platelet apoptosis and membrane integrity in resting platelets can be influenced with intensive physical stress induced by abnormal shear force in atherosclerotic vessels, mechanical artificial valve and microangiopathic conditions.…”