Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Bouckaert, Filip; Dols, Annemiek; Emsell, Louise; Winter, François‐Laurent De; Vansteelandt, Kristof; Claes, Lene; Sunaert, Stefan; Stek, Max L.; Sienaert, Pascal; Vandenbulcke, Mathieu

doi:10.1038/npp.2016.86

Cited by 84 publications

(65 citation statements)

References 51 publications

(77 reference statements)

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“…Finally, left and right HVC showed a positive correlation ( r (65) = 0.31, P = 0.011), but there was no relation seen with the age, number of depressive episodes, number of ECT sessions, gender, presence of psychotic symptoms, LOD vs. EOD, study center, switch to a different stimulation modality, or pretreatment HV levels. For a more elaborate discussion on HV evolution regarding this patient sample, we refer to Bouckaert et al .…”

Section: Discussionmentioning

confidence: 99%

“…As described by Bouckaert et al , structural MRI was performed within one week before and after ECT respectively T 0 ( n = 79) and

T_{1}

( n = 70). High‐resolution 3D T1‐weighted images were acquired using an eight‐channel head‐coil with a 3D turbo field echo sequence on a 3T Philips Intera Scanner in Leuven and on a 3T GE Signa HDct scanner in Amsterdam (TR = 9.6 s, TE = 4.6 s, flip angle = 8°, slice thickness = 1.2 mm, in‐plane voxel size = 0.98 × 0.98 × 1.2 mm 3 , 182 slices, acquisition time = 383 s).…”

Section: Methodsmentioning

confidence: 99%

“…Several factors, however, support the possibility of an association between volume changes and cognitive side‐effects. ECT‐induced HVC and cognitive side‐effects are both reported to be transient , , . Both appear to be related to ECT treatment technique .…”

Section: Introductionmentioning

confidence: 97%

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Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Laroy

Bouckaert

Vansteelandt

et al. 2019

Acta Psychiatr Scand

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Laroy M, Bouckaert F, Vansteelandt K, et al. Association between hippocampal volume change and change in memory following electroconvulsive therapy in late-life depression.Objective: Electroconvulsive therapy (ECT)-induced hippocampal volume change (HVC) has been repeatedly described in recent years. The similar time course of HVC and ECT-related cognitive effects suggest a relation, that is to date, understudied. This study investigates whether HVC following ECT predicts the change in memory performance six months after the end of the ECT treatment. Methods: Hippocampal volume (HV) was measured via high-resolution 3D T1weighted images in 88 patients with late-life depression, within 1 week before and after ECT. Memory performance was assessed before and six months after ECT. Multiple linear regression was used to examine whether change in memory performance could be predicted based on ECT-induced changes in HV. Results: Larger right absolute HVC predicts less pronounced improvement on the VAT (visual memory) in the whole sample. For the 8-Word Test (verbal memory), Category Fluency Test (semantic memory), and MMSE, the effect is only present in patients who switched from right unilateral to bitemporal stimulation after six ECT sessions. Absolute HVC in the left hemisphere was not significantly related to cognitive change. Conclusion: A larger absolute change in right HV during ECT is associated with less improvement in memory performance up to 6 months post-ECT.

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Section: Discussionmentioning

confidence: 99%

“…As described by Bouckaert et al , structural MRI was performed within one week before and after ECT respectively T 0 ( n = 79) and

T_{1}

Section: Methodsmentioning

confidence: 99%

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Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Laroy

Bouckaert

Vansteelandt

et al. 2019

Acta Psychiatr Scand

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“…Data in this study were derived from the MODECT, a prospective cohort study. 25,26 In total, 110 older persons (age > 55 years) with a unipolar major depressive disorder according to the DSM-IV criteria 27 referred for ECT, were recruited from 2 psychiatric hospitals (GGZinGeest, Amsterdam, the Netherlands and University Psychiatric Center, KU Leuven, Belgium). Exclusion criteria were a major neurological illness (including dementia and Parkinson's disease), or a DSM-IV diagnosis of bipolar-and schizoaffective disorder.…”

Section: Study Samplementioning

confidence: 99%

The course of apathy in late‐life depression treated with electroconvulsive therapy; a prospective cohort study

Carlier

Exel

Dols

et al. 2018

Int J Geriat Psychiatry

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Objectives Apathy, a lack of motivation, is frequently seen in older individuals, with and without depression, with substantial impact on quality of life. This prospective cohort study of patients with severe late‐life depression treated with electroconvulsive therapy (ECT) aims to study the course of apathy and the predictive value of vascular burden and in particular white matter hyperintensities on apathy course. Methods Information on apathy (defined by a score of >13 on the Apathy Scale), depression severity, vascular burden, and other putative confounders was collected in at 2 psychiatric hospitals on patients with late‐life depression (aged 55 to 87 years, N = 73). MRI data on white matter hyperintensities were available in 52 patients. Possible risk factors for apathy post‐ECT were determined using regression analyses. Results After treatment with ECT, 52.0% (26/50) of the depression remitters still suffered from clinically relevant apathy symptoms. In the entire cohort, more patients remained apathetic (58.9%) than depressed (31.5%). Presence of apathy post‐ECT was not associated with higher age, use of benzodiazepines, or severity of apathy and depression at baseline. Less response in depressive symptomatology after ECT predicted post‐treatment apathy. The presence of vascular disease, diabetes mellitus and smoking, and white matter hyperintensities in the brain was not associated with post‐treatment apathy. Conclusions Apathy may perpetuate in individual patients, despite remission of depressive symptoms. In this cohort of patients with late‐life depression, post‐ECT apathy is not associated with white matter hyperintensities.

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“…Structural imaging studies have revealed limbic structure enlargements following ECT in depressive patients . Some reports have described these ECT‐induced increases in gray matter volume as transient, while returning to baseline within 3 or 6 months . When evaluating the association between neural correlates and ECT efficacy, a recent mega‐analysis found no association between brain structure and treatment response .…”

Section: Introductionmentioning

confidence: 99%

Repetitive enhancement of serum BDNF subsequent to continuation ECT

Vanicek

Kranz

Vyssoki

et al. 2019

Acta Psychiatr Scand

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Introduction Continuation electroconvulsive therapy (c‐ECT) is highly effective for the prevention of depressive symptom relapse. There is a lack of understanding, about how c‐ECT works in humans, particularly with regard to its effects on brain derived neurotrophic factor (BDNF) concentrations. Here, we aimed to close a gap in the literature by evaluating BDNF levels in patients receiving c‐ECT. Methods We included 13 patients with either unipolar or bipolar depression (mean age ± SD: 55.5 ± 17.1; f/m: 10/3; unipolar/bipolar: 10/3) who received between one and four c‐ECT (average per patient: 2.8). Serum BDNF (sBDNF) levels were assessed before and after each c‐ECT sessions. Clinical assessments were also administered both before and after treatment. Results Our analysis revealed a significant increase in sBDNF after each treatment (c‐ECT 1‐3: P < 0.001, c‐ECT 4: P = 0.018). The application of multiple c‐ECT treatments was not, however, associated with further sBDNF enhancements. Psychometric scores were not significantly altered following c‐ECT. Discussion An increase in sBDNF concentrations subsequent to c‐ECT parallel data from the animal literature, which has linked regularly applied electrical stimulation to neuroplastic processes. This finding suggests a relationship between ECT‐induced sBDNF concentrations and (sustained) remission status, considering a stable clinical condition across c‐ECT.

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Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Cited by 84 publications

References 51 publications

Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

The course of apathy in late‐life depression treated with electroconvulsive therapy; a prospective cohort study

Repetitive enhancement of serum BDNF subsequent to continuation ECT

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