Relationship between High-Performance Liquid Chromatography Fingerprints and Uric Acid-Lowering Activities of  Cichorium intybus L.

Zhu, Chunsheng; Zhang, Bing; Lin, Zhijian; Wang, Xue-Jie; Zhou, Yue; Sun, Xiance; Xiao, Ming-Liang

doi:10.3390/molecules20059455

Cited by 23 publications

(19 citation statements)

References 15 publications

(17 reference statements)

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“…The evaluation of the levels of total protein and its fractions supply the information required to interpret the occurrence of dehydration under heat stress and inflammatory responses (Bounous, 2000). Zhu et al, (2015) assessed uric acid-lowering activities using high-performance liquid chromatography fingerprints and reported that Cichorium intybus has uric acid-lowering activities. Furthermore, Lin et al, (2014) reported that Cichorium intybus could reduce serum uric acid levels and inhibit liver xanthine dehydrogenase and xanthine oxidase.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Cichorium Intybus L. Ethanol Extraction on the Pathological and Biomedical Indexes of the Liver and Kidney of Broilers Reared Under Heat Stress

Khodadadi

Mousavinasab

Khamesipour

et al. 2016

Rev. Bras. Cienc. Avic.

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The use of compounds with antioxidant properties as a source of phelanoeid compounds is highly recommendable in the poultry industry. Therefore, the effect of Cichorium intybus L. herb on pathobiochemical indexes of chicken under heat stress was studied. After exposure to heat stress (from day 21 to day 42 of growth), hydroalcoholic extraction was provided to 270 broiler chicks randomly divided into six groups and placed in two distinct poultry houses (heat stress and normal conditions). The three groups were recipient group of Cichorium intybus L.(1); recipient group of vitamin C (2) and control group (3). The birds in one of the houses were exposed to heat stress conditions (35 °C for 8 hours) for a time period between 22 to 42 days and the birds in the other house were reared under normal conditions (20-22°C) for the same time period. Blood samples collected from the birds showed that Cichorium intybus L. herb caused significant decrease in uric acid, Triglyceride, Alanine aminotransferase (ALT), total body clearance factors (CL-factors) and right ventricular failure index (RVF) and significant increase in K + under heat stress condition (p<0.05). Vitamin C caused significant decrease in uric acid, ALT, CL-factors and RVF index and significant increase in K+ and Na+ under heat stress condition (p<0.05). A significant decrease in cholesterol and triglyceride in recipient group of Cichorium intybus L was observed compared to the recipient group of vitamin C under heat stress condition (p<0.05). In a pathologic examination normal observations were in recipient group of Cichorium intybus L and recipient group of vitamin C compared to the control group. According to this study, use of Cichorium intybus L extract and vitamin C in chicken under heat stress induced improvement in liver, kidney activity and fat metabolism.

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Section: Discussionmentioning

confidence: 99%

The Effect of Cichorium Intybus L. Ethanol Extraction on the Pathological and Biomedical Indexes of the Liver and Kidney of Broilers Reared Under Heat Stress

Khodadadi

Mousavinasab

Khamesipour

et al. 2016

Rev. Bras. Cienc. Avic.

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“…Various purification procedures of obtained extracts before analysis and (photo)oxidation of polyphenols were also carefully taken into consideration by various researchers (Cefola, Carbone, Minasi, & Pace, 2016;Carazzone et al, 2013;Innocenti et al, 2005;Rossetto et al, 2005). Some authors experimented also lyophilisation technique followed by ultrasonic assisted extraction (UAE) (Sinkovič et al, 2015) or reflux procedures (Zhu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic profile of Cichorium intybus L. endemic varieties from the Veneto region of Italy

et al. 2018

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“…To further identify whether the CSF of the rats treated with EUWE contains CGA, UHPLC-ESI-MS/MS with both positive and negative ion modes were employed to study the fragmentation behaviors of authentic standard of CGA in ESI-MS/MS at first in order to facilitate the structure characterization of the marker constituent. The marker constituent are identified according to their fragmentation data and comparison with the authentic standard from previous studies [33,34]. The ion fragmentations and structure of marker constituent are shown in Figure 7 and Scheme 1.…”

Section: Resultsmentioning

confidence: 99%

Antidepressant Potential of Chlorogenic Acid-Enriched Extract from Eucommia ulmoides Oliver Bark with Neuron Protection and Promotion of Serotonin Release through Enhancing Synapsin I Expression

Chen

et al. 2016

Molecules

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Eucommia ulmoides Oliver (E. ulmoides) is a traditional Chinese medicine with many beneficial effects, used as a tonic medicine in China and other countries. Chlorogenic acid (CGA) is an important compound in E. ulmoides with neuroprotective, cognition improvement and other pharmacological effects. However, it is unknown whether chlorogenic acid-enriched Eucommia ulmoides Oliver bark has antidepressant potential through neuron protection, serotonin release promotion and penetration of blood-cerebrospinal fluid barrier. In the present study, we demonstrated that CGA could stimulate axon and dendrite growth and promote serotonin release through enhancing synapsin I expression in the cells of fetal rat raphe neurons in vitro. More importantly, CGA-enriched extract of E. ulmoides (EUWE) at 200 and 400 mg/kg/day orally administered for 7 days showed antidepressant-like effects in the tail suspension test of KM mice. Furthermore, we also found CGA could be detected in the the cerebrospinal fluid of the rats orally treated with EUWE and reach the level of pharmacological effect for neuroprotection by UHPLC-ESI-MS/MS. The findings indicate CGA is able to cross the blood-cerebrospinal fluid barrier to exhibit its neuron protection and promotion of serotonin release through enhancing synapsin I expression. This is the first report of the effect of CGA on promoting 5-HT release through enhancing synapsin I expression and CGA-enriched EUWE has antidepressant-like effect in vivo. EUWE may be developed as the natural drugs for the treatment of depression.

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Relationship between High-Performance Liquid Chromatography Fingerprints and Uric Acid-Lowering Activities of Cichorium intybus L.

Cited by 23 publications

References 15 publications

The Effect of Cichorium Intybus L. Ethanol Extraction on the Pathological and Biomedical Indexes of the Liver and Kidney of Broilers Reared Under Heat Stress

The Effect of Cichorium Intybus L. Ethanol Extraction on the Pathological and Biomedical Indexes of the Liver and Kidney of Broilers Reared Under Heat Stress

Polyphenolic profile of Cichorium intybus L. endemic varieties from the Veneto region of Italy

Antidepressant Potential of Chlorogenic Acid-Enriched Extract from Eucommia ulmoides Oliver Bark with Neuron Protection and Promotion of Serotonin Release through Enhancing Synapsin I Expression

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