Relationship between herpes simplex virus ulceration and CD4+ cell counts in patients with HIV infection

Bagdades, Evis; Pillay, Deenan; Squire, SB; O'neil, C. E.; Johnson, Margaret; Griffiths, Paul

doi:10.1097/00002030-199211000-00012

Cited by 115 publications

(60 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The combination of OC with dysphagia or retrosternal pain thought to be a good predictor of esophageal involvement [18] (PEC) was a fairly sensitive criterion. Genital ulceration (GU) suggestive of herpes simplex infection had a tendency for chronicity (average duration of 2 months) and recurrence (in 16 out of the 26 AIDS patients) as described previously [19]. Chronic cough was a poor marker for AIDS, as shown in Africa also [20].…”

Section: Discussionmentioning

confidence: 71%

Evaluation of the WHO Clinical Case Definition of AIDS in the Indian Context: Suggesting a Prediction Rule

Kaushik¹,

Pandey

Pande³

2000

Med Princ Pract

View full text Add to dashboard Cite

Objective: To test the statistical significance of the existing World Health Organization (WHO) clinical case definition for the diagnosis of acquired immunodeficiency syndrome (AIDS) in areas where diagnostic resources are limited in India, and frame a prediction rule that is sensitive and specific for the clinical diagnosis of AIDS. Methodology and Results: In a case-load study, we evaluated the WHO clinical case definition of AIDS in 162 patients, the training set (58 seropositives) at the All India Institute of Medical Sciences, New Delhi. This definition had a sensitivity of about 29%, specificity of about 29%, positive predictive value of about 19% and negative predictive value of about 42%. We analyzed the clinical data of these 162 patients using stepwise logistic regression analysis. Generalized lymphadenopathy, oropharyngeal candidiasis, presumptive esophageal candidiasis, herpes zoster in the last 5 years and a total lymphocyte count of less than 1,000 × 10⁹/l emerged as important predictors. A prediction rule for the diagnosis of AIDS in the Indian context was then developed empirically using the coefficients of these predictors. We further tested the rule prospectively in 50 patients, the test set (11 seropositives) and found it to have a sensitivity of 81.8%, specificity of 97.4%, positive predictive value of 90%, and a negative predictive value of 95%. Conclusion: The WHO definition was not significant statistically for clinical use in India. The new prediction rule may help in AIDS surveillance in India.

show abstract

Section: Discussionmentioning

confidence: 71%

Evaluation of the WHO Clinical Case Definition of AIDS in the Indian Context: Suggesting a Prediction Rule

Kaushik¹,

Pandey

Pande³

2000

Med Princ Pract

View full text Add to dashboard Cite

show abstract

“…Moreover, it has been evidenced that HSV-2 significantly increases the dissemination of HIV in the genitalia of those co-infected with these viruses [113]. It is important to note that the relationship between HIV and HSV-2 is reciprocal, as infection with HIV also significantly increases the probability of acquiring HSV-2, and that reactivation with HSV-2 is more frequent in HIVpositive patients [114][115][116]. Noteworthy, the relationship between HSV-2 and HIV is synergic and goes beyond risk factors associated with the acquisition of these viruses.…”

Section: Relationship Between Hsv-2 and Hivmentioning

confidence: 99%

Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease

Suazo

Tognarelli

Kalergis

et al. 2014

Med Microbiol Immunol

View full text Add to dashboard Cite

Infection with herpes simplex viruses is one of the most ancient diseases described to affect humans. Infection with these viruses produces vexing effects to the host, which frequently recur. Infection with herpes simplex viruses is lifelong, and currently there is no vaccine or drug to prevent or cure infection. Prevalence of herpes simplex virus 2 (HSV-2) infection varies significantly depending on the geographical region and nears 20% worldwide. Importantly, HSV-2 is the first cause of genital ulcers in the planet. HSV-2 affects approximately 500 million people around the globe and significantly increases the likelihood of acquiring the human immunodeficiency virus (HIV), as well as its shedding. Thus, controlling HSV-2 infection and spread is of public health concern. Here, we review the diseases produced by herpes simplex viruses, the factors that modulate HSV-2 infection, the relationship between HSV-2 and HIV and novel therapeutic and prophylactic microbicides/antivirals under development to prevent infection and pathological outcomes produced by this virus. We also review mutations associated with HSV-2 resistance to common antivirals.

show abstract

“…19 Herpes simplex virus (HSV) is the other major viral infection of the skin in HIV-infected persons and is a common problem in patients with low CD4 counts. 20 In advanced HIV infection it often presents as ulceration without any prior history of blisters. Ulceration may be extensive, particularly in the anogenital region, and this is a common clinical scenario in resource-poor regions of the world where patients often present with advanced immunosuppression (Fig.…”

Section: Viral Skin Infectionsmentioning

confidence: 99%

The impact of human immunodeficiency virus-related diseases on pigmented skin types

Ameen

2013

Br J Dermatol

View full text Add to dashboard Cite

Relationship between herpes simplex virus ulceration and CD4+ cell counts in patients with HIV infection

Cited by 115 publications

References 0 publications

Evaluation of the WHO Clinical Case Definition of AIDS in the Indian Context: Suggesting a Prediction Rule

Evaluation of the WHO Clinical Case Definition of AIDS in the Indian Context: Suggesting a Prediction Rule

Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease

The impact of human immunodeficiency virus-related diseases on pigmented skin types

Contact Info

Product

Resources

About