Relationship between Hemostatic Markers and Circulating Biochemical Markers of Collagen Metabolism in Patients with Aortic Aneurysm

Abstract

Our objective was to determine the relationship between plasma levels of hemostatic molecular markers – D-dimer and thrombin-antithrombin III complex (TAT) – and circulating biochemical markers of collagen metabolism – aminoterminal propeptide of type III procollagen (PIIIP) and carboxyterminal propeptide of type I procollagen (PICP) – in patients with aortic aneurysm. The subjects were 43 patients with aortic aneurysm (AA; mean age 71 years) and 26 age-matched controls (mean age 75 years). The mean D-dimer, TAT and PIIIP levels were higher in the patients than in the controls (p < 0.0001, 0.0001 and 0.012, respectively), while the mean PICP level was similar to that in the controls. Increased D-dimer had a significant correlation with PIIIP (r = 0.412, p = 0.006) and PICP (r = 0.342, p = 0.0246), while TAT correlated with PIIIP (r = 0.3194, p = 0.0374), but not with PICP. There was also a significant correlation (r = 0.306, p = 0.0463) between PIIIP and PICP. As shown by the significant positive correlations among D-dimer, TAT and PIIIP, accelerated fibrinolysis and thrombogenesis induce an increase of collagen degradation and procollagen synthesis in atherosclerotic lesions. These findings show that D-dimer and TAT, especially the former, may be useful markers to monitor the progression and predict the prognosis of AA.

Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community

“…D-dimer has been correlated with collagen markers in conditions such as aortic aneurysms [29]; hence, our results suggest a relation between collagen metabolism and the general fibrinolytic system, with a stronger relation seen with the plasminogen/plasmin system.…”

Evaluation of Platelet Indexes in Patients with Aortic Aneurysm

“…Increased larger platelets in AC of the present study might possibly be a result of age-related atherosclerosis, possibly entailing chronic platelet consumption at the site of the atherosclerotic plaque. Thrombus formation is generally strong in patients with AA, as refl ected by elevated D-dimer and TAT [14,15] , especially in group B. The increase in platelet size was accompanied by a decrease in platelet count, and the life span of 'stress' platelets will be remarkably shortened and thus, as a compensatory response, thrombopoiesis may be strongly accelerated leading to the formation of lager platelets.…”

Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm

“…57 Thus, PF1 ϩ 2 and TAT are biomarkers of coagulation activation and thrombin generation. This review identified eight studies that reported on the effect of AAAs on the levels of one or both of these biomarkers [41][42][43]45,47,[50][51][52] ( Table II). Elevated levels of both TAT and PF1 ϩ 2 have been demonstrated in men with small AAAs Ͻ55 mm in diameter.…”