Relationship between hemodialysis and health-related quality of life: a cross-sectional study of diagnosis and duration of hemodialysis

Abstract

Background Hemodialysis is a medical technology implemented for various renal diseases and has a significant budget impact in Japan. Hemodialysis also affects health-related quality of life, as it interferes with daily life, but the effect of diagnosis and duration of hemodialysis is not clear. The purpose of this study was to examine the impact of hemodialysis on health-related quality of life, with a focus on diagnosis and duration of hemodialysis. Methods We conducted EQ-5D-5L surveys among hemodialysis patients at a single hemodialysis hospital between November 2015 and September 2017 and used a scoring algorithm that was developed in Japan to calculate the scores. Results A total of 274 subjects without missing data were included in the data analysis. The mean score of the entire group was 0.772 ± 0.215. Compared with other domains, pain/discomfort had the highest percentage of problems (59.1%). There were no differences in the distributions with respect to diagnostic names in any domain. Multiple regression analysis showed that hemodialysis duration was the only explanatory variable that had a mild significant effect on EQ-5D-5L scores, but it was not large. Conclusions QOL measured using the EQ-5D-5L survey score was not affected by age, gender, or diagnosis but was affected by hemodialysis duration. Future studies are needed to investigate the impact of prolonged hemodialysis on health-related quality of life.

Cost-Effectiveness of School Urinary Screening for Early Detection of IgA Nephropathy in Japan

“…Table 1 lists main input parameters identified by this model. Other parameters are listed in eTables 1 to 3 and eAppendix 5 in Supplement 1 . The annual incidence of IgAN was set at 4.5 cases per 100 000 people.…”

“…Other parameters are listed in eTables 1 to 3 and eAppendix 5 in Supplement 1 . 14 , 15 , 16 , 17 , 26 , 27 , 28 , 30 , 31 , 32 , 35 , 36 , 37 , 39 , 40 The annual incidence of IgAN was set at 4.5 cases per 100 000 people. The sensitivity of the screening for mild IgAN was assumed to be 0.8, referencing a previous study 16 in Niigata City, Japan.…”

“…Although there have been no reports of disutility due to IgAN, we accounted for disutility during treatment in sensitivity analysis. However, no data were available for youths with dialysis or transplant in Japan; therefore, values from Australian and New Zealand youths and Japanese adults with dialysis or transplant were used …”

“…However, no data were available for youths with dialysis or transplant in Japan; therefore, values from Australian and New Zealand youths and Japanese adults with dialysis or transplant were used. 35 , 36 , 37 …”

Cost-Effectiveness of Dapagliflozin for Chronic Kidney Disease in Japan

“…On the basis of previous studies, quality of life (QOL) for CKD, HD, and hospitalization for HF were set to 0.88, 0.77, and 0.68, respectively. 34- 36 In accordance with Japanese guidelines, all utilities were discounted at 2%/year. 28,29…”