Relationship between Helicobacter pylori infection and gastrointestinal microecology

Xu, Wenting; Xu, Liming; Xu, Caixia

doi:10.3389/fcimb.2022.938608

Cited by 25 publications

(20 citation statements)

References 79 publications

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“…It also boosts the number of microorganisms in stomach cancer, including nitrate-reducing bacteria, nitrosylobacteria, and E. coli , which promotes nitrate metabolism. The resultant N-nitroso compounds function as carcinogens and promote tumorigenesis[ 72 ]. An increasing body of evidence suggests that H. pylori infection also impacts the intestinal flora.…”

Section: Potential Carcinogenic Effect Of H Pylori ...mentioning

confidence: 99%

“…An increasing body of evidence suggests that H. pylori infection also impacts the intestinal flora. H. pylori invasion of the intestinal mucosa may lead to reduced intestinal permeability[ 72 ] and inhibit E. coli DNA[ 73 ]. H. pylori may also trigger host immune responses, thereby altering the intestinal flora[ 74 , 75 ].…”

Section: Potential Carcinogenic Effect Of H Pylori ...mentioning

confidence: 99%

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Relationship between Helicobacter pylori infection and colorectal polyp/colorectal cancer

Liu,

Yang,

Jiang

et al. 2024

World J Gastrointest Surg

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Helicobacter pylori (H. pylori ) plays an important role in the development of gastric cancer, although its association to colorectal polyp (CP) or colorectal cancer (CRC) is unknown. In this issue of World Journal of Gastrointestinal Surgery , Zhang et al investigated the risk factors for H. pylori infection after colon polyp resection. Importantly, the researchers used R software to create a prediction model for H. pylori infection based on their findings. This editorial gives an overview of the association between H. pylori and CP/CRC, including the clinical significance of H. pylori as an independent risk factor for CP/CRC, the underlying processes of H. pylori -associated carcinogenesis, and the possible risk factors and identification of H. pylori .

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Section: Potential Carcinogenic Effect Of H Pylori ...mentioning

confidence: 99%

Section: Potential Carcinogenic Effect Of H Pylori ...mentioning

confidence: 99%

Relationship between Helicobacter pylori infection and colorectal polyp/colorectal cancer

Liu,

Yang,

Jiang

et al. 2024

World J Gastrointest Surg

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“…It has been shown that the gut microbiota composition and function can impact the pharmacokinetics and pharmacodynamics of antibiotics, which are a key component of H. pylori eradication therapies. By modulating the gut microbiota, it may be possible to enhance the e cacy of H. pylori eradication therapies and reduce the risk of treatment failure (21). Inhibition of H. pylori growth: Some probiotic strains, such as Lactobacillus and Bi dobacterium, have been shown to produce antimicrobial compounds that can inhibit the growth of H. pylori.…”

Section: The Potential Role Of the Gut Microbiota In H Pylori Eradica...mentioning

confidence: 99%

Probiotics and Diet Modifications: A Holistic Approach to Tackling Helicobacter pylori with the Help of the Gut Microbiota

Addissouky

Wang

Sayed

et al. 2023

Preprint

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Background Helicobacter pylori is a common gastrointestinal bacterium that can cause a range of diseases, including gastritis, peptic ulcer disease, and gastric cancer. The gut microbiota plays an important role in H. pylori colonization and associated diseases. Main body: Lifestyle factors, such as diet, stress, smoking, and alcohol consumption, can impact the gut microbiota composition and function, and may influence the risk of H. pylori colonization and H. pylori-associated diseases. Strategies to promote gut health, such as a healthy diet, stress reduction, smoking cessation, alcohol moderation, regular exercise, adequate sleep, antibiotic stewardship, and probiotic supplementation, may help to reduce the risk of H. pylori colonization and enhance the effectiveness of H. pylori eradication therapy. Furthermore, the gut microbiota may also be a potential target for H. pylori eradication, and personalized treatment approaches based on individual patient characteristics may be necessary to optimize H. pylori eradication rates and reduce the risk of adverse effects. Conclusion Further research is needed to better understand the role of the gut microbiota in H. pylori eradication and to develop more effective treatment strategies. By promoting gut health and developing personalized treatment approaches, we may be able to reduce the burden of H. pylori-associated diseases and improve patient outcomes.

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“…H. pylori is a bacterium characterized by its spiral shape and gram-negative nature, which has a global prevalence, surpassing 50% of the global population, with greater occurrence in developing nations. It is widely recognized as the primary etiological factor responsible for chronic or atrophic gastritis, peptic ulcer, gastric lymphoma, and gastric carcinoma [ 31 ]. Considering its carcinogenic properties, the World Health Organization has classified H. pylori as a grade I carcinogen [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology

Gouda,

Saied,

Edrees

et al. 2024

BMC Infect Dis

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Background Toxoplasma gondii (T. gondii) and Helicobacter pylori (H. pylori) are among the most prevalent foodborne parasitic and bacterial infections worldwide. However, the concurrent impact of coinfection on gastric pathology has yet to be studied in depth. The effect of coinfection generally either adds a synergetic or antagonistic impact; we aimed in the current work to assess the impact of T. gondii coinfection on the progression of H. pylori-associated gastric pathology and reporting H. pylori virulent strains. The study was conducted on 82 patients complaining of persistent gastrointestinal symptoms with failed treatment response and prone to endoscopy. They were subjected to stool examination to detect H. pylori antigen, serological screening for latent toxoplasmosis, endoscopy, histopathological examination, and molecular detection of H. pylori virulence strains in gastric biopsies. Out of the 82 patients, 62 patients were positive for H. pylori antigen in stool and 55 patients confirmed positivity by histopathology; out of them, 37 patients had isolated Vac As1 variants, 11 patients had combined Vac As1 and Cag A variants, and 7 patients had combined Vac As1, Cag A and VacAs2 variants. Patients with the combined two or three variances showed significantly deteriorated histopathological features than patients with a single Vac As1 variant (P < 0.05). Latent toxoplasmosis was positive among 35/82 patients. Combined H. pylori and Toxoplasma gondii infection had significantly marked inflammation than patients with isolated infection (P < 0.05). Conclusion: Screening for toxoplasmosis among H. pylori-infected patients is recommended as it is considered a potential risk factor for gastric inflammation severity. H. pylori gastric inflammation may be heightened by Toxoplasma coinfection.

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Relationship between Helicobacter pylori infection and gastrointestinal microecology

Cited by 25 publications

References 79 publications

Relationship between Helicobacter pylori infection and colorectal polyp/colorectal cancer

Relationship between Helicobacter pylori infection and colorectal polyp/colorectal cancer

Probiotics and Diet Modifications: A Holistic Approach to Tackling Helicobacter pylori with the Help of the Gut Microbiota

Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology

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