Relationship between heat shock proteins and cellular resistance to drugs and ageing

Peinado-Ruiz, Isabel C.; Burgos-Molina, Antonio Manuel; Portero, F. Sendra; Ruiz-Gómez, Miguel J

doi:10.1016/j.exger.2022.111896

Cited by 10 publications

(6 citation statements)

References 55 publications

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“…These findings support that PTT plus PET-responsive P6@PEDOT@PLT possess vascular protective effects owing to HSP expression, ROS reduction, and M2 macrophage polarization. According to previously published findings, phototherapy enables the damaged tissue to express HSP for speeding up the repair process . In addition, the earlier published literature reported that HSP promotes the production of anti-inflammatory cytokines for the sequential anti-inflammatory response .…”

Section: Resultsmentioning

confidence: 89%

Biomimetic Platelet Nanomotors for Site-Specific Thrombolysis and Ischemic Injury Alleviation

Chen

Liu

Pan

et al. 2023

ACS Appl. Mater. Interfaces

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Due to the mortality associated with thrombosis and its high recurrence rate, there is a need to investigate antithrombotic approaches. Noninvasive site-specific thrombolysis is a current approach being used; however, its usage is characterized by the following limitations: low targeting efficiency, poor ability to penetrate clots, rapid half-life, lack of vascular restoration mechanisms, and risk of thrombus recurrence that is comparable to that of traditional pharmacological thrombolysis agents. Therefore, it is vital to develop an alternative technique that can overcome the aforementioned limitations. To this end, a cotton-ball-shaped platelet (PLT)-mimetic self-assembly framework engineered with a phototherapeutic poly(3,4-ethylenedioxythiophene) (PEDOT) platform has been developed. This platform is capable of delivering a synthetic peptide derived from hirudin P6 (P6) to thrombus lesions, forming P6@PEDOT@PLT nanomotors for noninvasive site-specific thrombolysis, effective anticoagulation, and vascular restoration. Regulated by P-selectin mediation, the P6@PEDOT@PLT nanomotors target the thrombus site and subsequently rupture under near-infrared (NIR) irradiation, achieving desirable sequential drug delivery. Furthermore, the movement ability of the P6@PEDOT@PLT nanomotors under NIR irradiation enables effective penetration deep into thrombus lesions, enhancing bioavailability. Biodistribution analyses have shown that the administered P6@PEDOT@PLT nanomotors exhibit extended circulation time and metabolic capabilities. In addition, the photothermal therapy/photoelectric therapy combination can significantly augment the effectiveness (ca. 72%) of thrombolysis. Consequently, the precisely delivered drug and the resultant phototherapeutic-driven heat-shock protein, immunomodulatory, anti-inflammatory, and inhibitory plasminogen activator inhibitor-1 (PAI-1) activities can restore vessels and effectively prevent rethrombosis. The described biomimetic P6@PEDOT@PLT nanomotors represent a promising option for improving the efficacy of antithrombotic therapy in thrombus-related illnesses.

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Section: Resultsmentioning

confidence: 89%

Biomimetic Platelet Nanomotors for Site-Specific Thrombolysis and Ischemic Injury Alleviation

Chen

Liu

Pan

et al. 2023

ACS Appl. Mater. Interfaces

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“…Furthermore, to demonstrate the common origin of these mechanisms, it is relevant to reference studies in eukaryotes. These studies establish correlations between temperature adaptation mechanisms and the evasion or attenuation of various drugs, for instance, studies related to breast cancer [ 102 ] or the pathophysiology of human diseases [ 103 ]. In K. pneumoniae , there is a scarcity of literature that relates these two mechanisms.…”

Section: The Impact Of Cellular Homeostasis On K Pneumoniae...mentioning

confidence: 99%

Relevance of the Adjuvant Effect between Cellular Homeostasis and Resistance to Antibiotics in Gram-Negative Bacteria with Pathogenic Capacity: A Study of Klebsiella pneumoniae

Rivera-Galindo,

Aguirre-Garrido,

Garza-Ramos

et al. 2024

Antibiotics

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Antibiotic resistance has become a global issue. The most significant risk is the acquisition of these mechanisms by pathogenic bacteria, which can have a severe clinical impact and pose a public health risk. This problem assumes that bacterial fitness is a constant phenomenon and should be approached from an evolutionary perspective to develop the most appropriate and effective strategies to contain the emergence of strains with pathogenic potential. Resistance mechanisms can be understood as adaptive processes to stressful conditions. This review examines the relevance of homeostatic regulatory mechanisms in antimicrobial resistance mechanisms. We focus on the interactions in the cellular physiology of pathogenic bacteria, particularly Gram-negative bacteria, and specifically Klebsiella pneumoniae. From a clinical research perspective, understanding these interactions is crucial for comprehensively understanding the phenomenon of resistance and developing more effective drugs and treatments to limit or attenuate bacterial sepsis, since the most conserved adjuvant phenomena in bacterial physiology has turned out to be more optimized and, therefore, more susceptible to alterations due to pharmacological action.

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“…Naturally, it was interesting to find out how the Hsp70 family members function in the case of various pathologies accompanied by disturbances in cellular protein synthesis and degradation, and whether the levels of Hsp70 and other chaperones in various tissues can be used as an indicator of disease and physical condition in humans. Indeed, it was shown that during normal aging, the level of Hsp70 is significantly reduced in animals and humans [128][129][130]. Hsp70 levels decrease in humans during aging in most organs, including neurons, leading to the accumulation of damaged and unfolded proteins.…”

Section: Hsp70 As a Biomarker Of Pathological Processes And Diseasesmentioning

confidence: 99%

“…This contributes to proteotoxicity, which may lead to the development of age-related diseases due to neurodegeneration. Aging also leads to the attenuation or alteration of many signaling pathways, as well as the expression of several transcription factors, including major heat shock factor (HSF1) [129][130][131]. Characteristically, aging decreases the level of Hsp70 induction after stress [132].…”

Section: Hsp70 As a Biomarker Of Pathological Processes And Diseasesmentioning

confidence: 99%

The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application

Evgen’ev¹,

Onikienko²,

Chuvakova³

et al. 2023

Front. Biosci. (Landmark Ed)

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In the present era of global warming and dramatically increased environmental pollution posing a threat to animal life, the understanding and manipulation of organisms' resources of stress tolerance is apparently a question of survival. Heat stress and other forms of stressful factors induce a highly organized response of organisms at the cellular level where heat shock proteins (Hsps) and in particular Hsp70 family of chaperones are among the major players in the protection from the environmental challenge. The present review article summarizes the peculiarities of the Hsp70 family of proteins protective functions being a result of many millions of years of adaptive evolution. It discusses the molecular structure and specific details of hsp70 gene regulation in various organisms, living in diverse climatic zones, with a special emphasis on the protective role of Hsp70 in adverse conditions of the environment. The review discusses the molecular mechanisms underlying Hsp70-specific properties that emerged in the course of adaptation to harsh environmental conditions. This review also includes the data on the anti-inflammatory role of Hsp70 and the involvement of endogenous and recombinant Hsp70 (recHsp70) in proteostatic machinery in various pathologies including neurodegenerative ones such as Alzheimer's and Parkinson's diseases in rodent model organisms and humans in vivo and in vitro. Specifically, the role of Hsp70 as an indicator of disease type and severity and the use of recHsp70 in several pathologies are discussed. The review discusses different roles exhibited by Hsp70 in various diseases including the dual and sometimes antagonistic role of this chaperone in various forms of cancer and viral infection including the SARS-Cov-2 case. Since Hsp70 apparently plays an important role in many diseases and pathologies and has significant therapeutic potential there is a dire need to develop cheap recombinant Hsp70 production and further investigate the interaction of externally supplied and endogenous Hsp70 in chaperonotherapy.

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Relationship between heat shock proteins and cellular resistance to drugs and ageing

Cited by 10 publications

References 55 publications

Biomimetic Platelet Nanomotors for Site-Specific Thrombolysis and Ischemic Injury Alleviation

Biomimetic Platelet Nanomotors for Site-Specific Thrombolysis and Ischemic Injury Alleviation

Relevance of the Adjuvant Effect between Cellular Homeostasis and Resistance to Antibiotics in Gram-Negative Bacteria with Pathogenic Capacity: A Study of Klebsiella pneumoniae

The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application

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