Relationship between gut microbiota and type 2 diabetic erectile dysfunction in Sprague-Dawley rats

Li, Hao; Qi, Tao; Huang, Zenan; Ying, Ying; Wang, Bo; Ye, Lei; Zhou, Bin; Chen, Diling; Chen, Jun

doi:10.1007/s11596-017-1767-z

Cited by 40 publications

(34 citation statements)

References 34 publications

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“…Indeed, as demonstrated in two different studies, PFS patients showed erectile dysfunction [13,14]. In agreement with the present results, gut microbiota population is also altered in an experimental model of diabetic erectile dysfunction [49].…”

Section: Discussionsupporting

confidence: 93%

Alterations of gut microbiota composition in post-finasteride patients: a pilot study

Borgo

Macandog

Diviccaro

et al. 2020

J Endocrinol Invest

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Purpose Post-finasteride syndrome (PFS) has been reported in a subset of patients treated with finasteride (an inhibitor of the enzyme 5alpha-reductase) for androgenetic alopecia. These patients showed, despite the suspension of the treatment, a variety of persistent symptoms, like sexual dysfunction and cognitive and psychological disorders, including depression. A growing body of literature highlights the relevance of the gut microbiota-brain axis in human health and disease. For instance, alterations in gut microbiota composition have been reported in patients with major depressive disorder. Therefore, we have here analyzed the gut microbiota composition in PFS patients in comparison with a healthy cohort. Methods Fecal microbiota of 23 PFS patients was analyzed by 16S rRNA gene sequencing and compared with that reported in ten healthy male subjects. Results Sexual dysfunction, psychological and cognitive complaints, muscular problems, and physical alterations symptoms were reported in more than half of the PFS patients at the moment of sample collection. The quality sequence check revealed a low library depth for two fecal samples. Therefore, the gut microbiota analyses were conducted on 21 patients. The α-diversity was significantly lower in PFS group, showing a reduction of richness and diversity of gut microbiota structure. Moreover, when visualizing β-diversity, a clustering effect was found in the gut microbiota of a subset of PFS subjects, which was also characterized by a reduction in Faecalibacterium spp. and Ruminococcaceae UCG-005, while Alloprevotella and Odoribacter spp were increased compared to healthy control. Conclusion Gut microbiota population is altered in PFS patients, suggesting that it might represent a diagnostic marker and a possible therapeutic target for this syndrome.

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Section: Discussionsupporting

confidence: 93%

Alterations of gut microbiota composition in post-finasteride patients: a pilot study

Borgo

Macandog

Diviccaro

et al. 2020

J Endocrinol Invest

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show abstract

“…and Bifidobacterium spp. were related to type 2 diabetes [40]. Taken together, our results showed that the abundance of gut microbiota changed after PPM supplementation, indicating that the role of PPM in alleviating IR may be potentiated by regulating the intestinal microecology.…”

Section: Discussionsupporting

confidence: 50%

Water extract from processed Polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin resistant rats

Yang

et al. 2020

BMC Complement Med Ther

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Background: The incidence of insulin resistance (IR) has rapidly increased worldwide over the last 20 years, no perfect solution has yet been identified. Finding new therapeutic drugs will help improve this situation. As a traditional Chinese medicine, PPM (processed Polygonum multiflorum) has widely been used in the clinic. Recently, other clinical functions of PPM have been widely analyzed. Results: Administration of the water extract from PPM decreased the level of FBG, TC, and TG, and increased the level of FGC, thereby reducing the IR index and improving IR. Furthermore, Western blot analysis revealed that PPM significantly increased GPR43 and AMPK expression when compared with the MOD group, and GPR43, AMPK were known as glucose metabolism-related proteins. In addition, treatment with PPM can restore the balance of gut microbiota by adjusting the relative abundance of bacteria both at the phylum and genus level, and these changes have been reported to be related to IR. Methods: Sprague Dawley (SD) rats were fed a high-fat diet and were gavaged daily with either normal saline solution or PPM for 12 weeks. Major biochemical indexes, such as fasting blood glucose (FBG), fasting glucagon (FGC), total cholesterol (TC), and triglyceride (TG) were measured. Then the protein expression of adenosine 5′monophosphate-activated protein kinase (AMPK) and G protein-coupled receptor 43 (GPR43) was evaluated by using Western blot analysis. Moreover, the composition of gut microbiota was assessed by analyzing 16S rRNA sequences. Conclusions: Our findings showed that PPM reversed the increasing of FBG and the decreasing of IRI, PPM accelerated the expression of glucose metabolism-related proteins and regulated the intestinal microecological balance. Therefore, we hold the opinion that PPM may be an effective option for treating IR.

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“…Specifically, the stool microbiome of STEMI patients had a higher abundance of Aerococcaceae and Eubacterium and a lower abundance of the beneficial microbe family Lachnospiraceae, results that were associated with serum TMAO levels. In another study, compared with controls, patients with type 2 diabetic erectile dysfunction who had increased serum TMAO levels also had a corresponding increase in relative abundance of Aerococcus (opportunistic pathogens) and a decrease in Eubacterium 27 . In mice, Lactobacillus plantarum ZDY04 significantly reduced serum TMAO and cecal TMA levels by modulating the relative abundance of beneficial Lachnospiraceae; also, L. plantarum ZDY04 is shown to significantly inhibit the development www.nature.com/scientificreports www.nature.com/scientificreports/ Figure 3.…”

Section: Discussionmentioning

confidence: 95%

Gut microbial taxa as potential predictive biomarkers for acute coronary syndrome and post-STEMI cardiovascular events

Gao

Yan

Wang

et al. 2020

Sci Rep

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plasma trimethylamine n-oxide (tMAo) is associated with coronary atherosclerotic plaque and cardiovascular disease risk, but associations between gut microbes in acute coronary syndrome (AcS) and post-St-segment elevation myocardial infarction (post-SteMi) events are unknown. We investigated associations between gut microbial taxa and systemic tMAo levels and the possible TMAO contribution to incident post-STEMI cardiovascular events. Patients and Methods. A total of 60 patients, including 30 with unstable angina pectoris (UAP), 30 post-STEMI and 30 healthy controls, were enrolled from June to November 2017. Metagenomic sequencing was performed and TMAO and IL-6 were detected. Results. Minimal discriminators of gut microbial taxa (top 40) distinguished AcS patients from controls. Serum tMAo levels were positively associated with increased abundance of Aerococcaceae, Ruminococcaceae_UCG.005, Ruminococcaceae_UCC.014 and X. Eubacterium_ fissicatena, and decreased abundance of Lachnospiraceae_FCS020 (p < 0.05). Elevated serum TMAO levels correlated independently with AcS (p < 0.05). Risk stratification for incident major adverse cardiovascular events (MAce) improved at one year in patients with serum tMAo levels ≦2.19 µM. Serum interleukin-6 levels were not significantly increased in patients with ACS and post-STEMI MACE. conclusions. AcS and incident post-SteMi MAce may be associated with the gut bacteria choline metabolite TMAO. The specific gut microbial taxa identified in association with serum TMAO levels may be potential predictive biomarkers for accurate diagnosis of AcS onset.

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Relationship between gut microbiota and type 2 diabetic erectile dysfunction in Sprague-Dawley rats

Cited by 40 publications

References 34 publications

Alterations of gut microbiota composition in post-finasteride patients: a pilot study

Alterations of gut microbiota composition in post-finasteride patients: a pilot study

Water extract from processed Polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin resistant rats

Gut microbial taxa as potential predictive biomarkers for acute coronary syndrome and post-STEMI cardiovascular events

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