Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population

Meng, Guang; Wang, Hongmei; Fang, Liyun; Li, Chunlei; Yu, Fei; Zhang, Qing; Liu, Li; Du, Huanmin; Shi, Hongbin; Xia, Yang; Guo, Xiaoyan; Liu, Xing; Bao, Xue; Su, Qian; Gu, Yeqing; Yang, Huijun; Yu, Bin; Wu, Yang; Sun, Zilin; Niu, Kaijun

doi:10.1038/srep33255

Cited by 45 publications

(49 citation statements)

References 47 publications

(70 reference statements)

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“…As for muscle function, grip strength has been analyzed previously in a large Asian cohort that found an inverse association between grip strength (relative to body weight) and NAFLD. (38) In our study, incremental grip strength was associated with lower NAFLD prevalence in men only; however, this association did not hold significance after multivariable adjustment.…”

Section: Discussioncontrasting

confidence: 78%

Nonalcoholic Fatty Liver Disease in The Rotterdam Study: About Muscle Mass, Sarcopenia, Fat Mass, and Fat Distribution

Alferink

Trajanoska

Erler

et al. 2019

Journal of Bone and Mineral Research

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Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. Obesity is a major risk factor for NAFLD and recently, low skeletal muscle mass emerged as additional risk factor for NAFLD. However, the different contributions of body mass index (BMI) to the risk of NAFLD are not yet well‐known. We therefore studied body composition and muscle function with NAFLD in an elderly population‐based study. Participants of European descent underwent dual‐energy X‐ray absorptiometry (DXA) and hepatic ultrasonography. NAFLD was defined as liver steatosis in absence of secondary causes for steatosis. Skeletal muscle index (SMI) was defined as appendicular lean mass/height2 and (pre)sarcopenia was defined using the European Working Group on Sarcopenia in Older People (EWGSOP) consensus guidelines. All analyses were stratified by sex and BMI (cut point: 25 kg/m2) and adjusted for age, weight, height, homeostasis model assessment of insulin resistance (HOMA‐IR), triglycerides, and android‐fat‐to‐gynoid‐fat ratio (AGR). We included 4609 participants, of whom 1623 had NAFLD (n = 161 normal‐weight and n = 1462 overweight). Presarcopenia and sarcopenia prevalence was low (5.9% and 4.5%, respectively) and both were not associated with NAFLD. SMI was associated with less NAFLD in normal‐weight women (OR, 0.48; 95% CI, 0.29 to 0.80). A similar association for SMI and NAFLD was seen in normal‐weight men, but significance dissipated after adjustment for AGR (OR, 0.63; 95% CI, 0.39 to 1.02). Generally, fat mass was a better predictor for NAFLD than lean mass. In particular, android fat mass was associated with all NAFLD subgroups (OR from 1.77 in overweight men to 8.34 in normal‐weight women, p max = 0.001), whereas substitution of gynoid fat mass for other body components had a significant protective association with NAFLD in every subgroup, but normal‐weight men. Likewise, AGR was the best performing predictor for NAFLD prevalence (OR from 1.97 in normal‐weight men to 4.81 in normal‐weight women, p max < 0.001). In conclusion, both high fat mass and low SMI were associated with normal‐weight NAFLD. However, fat distribution (as assessed by AGR) could best predict NAFLD prevalence. © 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc.

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Section: Discussioncontrasting

confidence: 78%

Nonalcoholic Fatty Liver Disease in The Rotterdam Study: About Muscle Mass, Sarcopenia, Fat Mass, and Fat Distribution

Alferink

Trajanoska

Erler

et al. 2019

Journal of Bone and Mineral Research

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“…Sarcopenia, a condition of low skeletal muscle mass, has been linked to increased risk of NAFLD and advanced fibrosis . Skeletal muscle function, too, may influence NAFLD; greater hand grip strength has been linked to decreased NAFLD prevalence . Further, NAFLD is associated with the substitution of adipose tissue in skeletal muscle and increased insulin resistance of skeletal muscle .…”

mentioning

confidence: 99%

Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis

et al. 2019

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Up to 25% of patients with nonalcoholic fatty liver disease (NAFLD) are not obese but may have a fat or muscle composition that predisposes them to NAFLD. Our aim was to determine whether body composition parameters associate with NAFLD and to identify genetic contributors to this association. This study included two cohorts. The first included 2,249 participants from the Framingham Heart Study who underwent a computed tomography scan to evaluate hepatic steatosis, dual‐energy x‐ray absorptiometry testing to assess body composition, and clinical examination. Body composition parameters were normalized to total body weight. A subset of participants underwent genotyping with an Affymetrix 550K single‐nucleotide polymorphism array. The second cohort, Michigan Genomics Initiative, included 19,239 individuals with genotyping on the Illumina HumanCoreExome v.12.1 array and full electronic health record data. Using sex‐stratified multivariable linear regression, greater central body fat associated with increased hepatic steatosis while greater lower extremity body fat associated with decreased hepatic steatosis. Greater appendicular lean mass was associated with decreased hepatic steatosis in men but not in women. A polygenic risk score for lipodystrophy (regional or global loss of adipose tissue) was associated with increased hepatic steatosis, increased liver fibrosis, and decreased lower extremity fat mass. Conclusion: Greater central body fat associated with increased hepatic steatosis, while greater lower extremity body fat and, in men, greater appendicular lean mass were associated with decreased hepatic steatosis. A genetic risk score for lipodystrophy was associated with NAFLD and liver fibrosis. Our results suggest that buffering of excess energy by peripheral fat and muscle may protect against NAFLD and liver fibrosis in the general population.

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“…[11] A recent study reported a strong relationship between handgrip strength and obesity and metabolic syndrome in adults and adolescents. [12][13][14][15][16] Steffl et al showed that handgrip strength can help identify children at risk for sarcopenic obesity. [11] The handgrip strength represents the strength of the simple muscle force, however, it can also represent something more important.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies argue that muscle mass alone cannot explain the patients' overall health status [22]. Therefore, Meng Ge et al suggested that assessing muscle strength may be more valuable than measuring muscle mass [14]. Thus, HGtW represents muscle quality and is more important than HG alone.…”

mentioning

confidence: 99%

Trends in Measures of Handgrip Strength from 2014 to 2017 Among Korean Adolescents using the Korean National Health and Nutrition Examination Survey Data

Kang

Kim

et al. 2020

Preprint

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Abstract Object: Measuring handgrip strength is a useful method to evaluate sarcopenia. No study has shown the trends of muscle quality among Korean adolescents by year. This study aimed to determine the trends of handgrip strength among Korean adolescents using data from the Korea National Health and Nutrition Examination Survey (KNHANES). Data of 2,304 adolescents who participated in the KNHANES between 2014 and 2017 were obtained. Muscle quality was estimated by dividing handgrip strength by body weight (handgrip-to-weight ratio). The handgrip-to-weight ratios were categorized by age, sex, and year. Results: Handgrip strength in adolescents decreased from 28.67kg in 2014 to 27kg in 2017. (P for trend<0.05) The handgrip-to-weight ratio also decreased from 51.48 in 2014 to 48.18 in 2017 (P for trend<0.05). The handgrip strength and handgrip-to-weight ratio also decreased among boys and girls over the years 2014–2017 (P for trend<0.05). The results of the present study indicate that the handgrip-to-weight ratio decreased in Korean adolescents from the years 2014 to 2017, and a declining overall ratio indicates a decrease in the quality of muscles among Korean adolescents. Hence, there is a need to review the health status of Korean adolescents.

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Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population

Cited by 45 publications

References 47 publications

Nonalcoholic Fatty Liver Disease in The Rotterdam Study: About Muscle Mass, Sarcopenia, Fat Mass, and Fat Distribution

Nonalcoholic Fatty Liver Disease in The Rotterdam Study: About Muscle Mass, Sarcopenia, Fat Mass, and Fat Distribution

Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis

Trends in Measures of Handgrip Strength from 2014 to 2017 Among Korean Adolescents using the Korean National Health and Nutrition Examination Survey Data

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