Relationship between glucose control, glycemic variability, and oxidative stress in children with type 1 diabetes

Colomo, Natalia; López-Siguero, Juan Pedro; Leiva, Isabel; Fuentes, Noemí; Rubio‐Martín, Elehazara; Omiste, Antonio; Guerrero, Mercedes; Tapia, María José; Martín-Tejedor, Beatriz; Adana, María Soledad Ruiz de; Olveira, Gabriel

doi:10.1016/j.endinu.2018.12.010

Cited by 4 publications

(6 citation statements)

References 31 publications

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“…GV is a metric that provides an integrated picture of postprandial hyperglycemia and hypoglycemic episodes. GV has been hypothesized to be an independent risk factor for vascular disease, independent of HbA1c ( 12 , 13 , 14 ). Increased GV is consistently associated with mortality and is a consistent predictor of hypoglycemia, both in prospective studies and randomized clinical trials ( 15 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

The Value of Telemedicine for the Follow-up of Patients with New Onset Type 1 Diabetes Mellitus During COVID-19 Pandemic in Turkey: A Report of Eight Cases

Evin

Ata

et al. 2021

Jcrpe

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The current Coronavirus disease-2019 (COVID-19) pandemic has forced health care teams to look for alternative approaches to manage a great number of children with diabetes, not only in rural but also in urban locations. The aim was to assess the provision of information about follow-up of new-onset pediatric type 1 diabetes (T1D) patients, and to investigate the integration of telemedicine into routine clinical care in the long term. The changes in coefficient of variation (CV), standard deviation and percentages of time in range (TIR), time below range (TBR) and time above range were evaluated in eight children with new-onset T1D, diagnosed during the COVID-19 pandemic. The study period was two-months of follow-up using a telemedicine system. Median follow-up time was 51 (24-66) days. Two of the patients were using low glucose suspend system and six were on multiple daily injection therapy. Target TIR values were achieved in seven patients in the last televisit and, in line with recent guidelines, a TBR <70 mg/dL (<3.9 mmol/L) (level 1 hypoglycemia) of <4% and a TBR <54 mg/dL (<3.0 mmol/L) (level 2 hypoglycemia) of <1% were achieved in all patients. Seven patients achieved a CV of <36% at their last televisit. Telemedicine as an alternative follow-up tool during unusual circumstances such pandemics, even in countries where it is not routinely used, could be beneficial to achieve optimum glycemic control in patients with new-onset T1D.

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Section: Discussionmentioning

confidence: 99%

The Value of Telemedicine for the Follow-up of Patients with New Onset Type 1 Diabetes Mellitus During COVID-19 Pandemic in Turkey: A Report of Eight Cases

Evin

Ata

et al. 2021

Jcrpe

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“…Another study exhibited that better glycemic control in terms of FPG and day-to-day GV led to the reduction of oxidative stress in patients with type two diabetes mellitus (T2DM). 22 Furthermore, Colomo et al 23 assessed for the first time the relationship between GV and oxidative stress in children with type one diabetes mellitus (T1DM). They measured oxidative stress using urinary secretion of 8-iso-PGF 2 , and they estimated GV as CV, MAGE, and SD, evaluating the patients for five days and proving that there was a significant correlation between oxidative stress and parameters of GV.…”

Section: Pathogenic Backgroundmentioning

confidence: 99%

Short-term Glycemic Variability and Its Association With Macrovascular and Microvascular Complications in Patients With Diabetes

Psoma

Makris

Tselepis

et al. 2022

J Diabetes Sci Technol

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The introduction of continuous glucose monitoring inaugurated a new era in clinical practice by shifting the characterization of glycemic control from HbA1c to novel metrics. The one that gained widespread attention over the past decades was glycemic variability (GV), which typically refers to peaks and nadirs of blood glucose measured over a given time interval. GV can be dichotomized into two main categories: short-term and long-term. Short-term GV reflects within-day and between-day glycemic oscillations, and its contribution to diabetic complications remains an enigma. In this review, we summarize the available data about short-term GV and its possible association with both microvascular and macrovascular complications, evaluating different pathogenic mechanisms and demonstrating nonpharmaceutical, as well as pharmaceutical, therapeutic interventions.

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“…Известно, что β-клетки поджелудочной железы особенно чувствительны к ОС из-за их высокой эндогенной продукции АФК и низкой антиоксидантной способности, что позволяет предположить, что ОС может играть важную роль в разрушении β-клеток [20,23,24]. β-клетки экспрессируют низкие уровни антиоксидантных ферментов и тем самым повышают свою восприимчивость к ОС, что приводит к их повреждению и запускают «порочный круг» [21,25,26]. Приводятся данные свидетельствующие о роли АФК в нарушении функции β-клеток именно на фоне СД 1-го типа в детском возрасте, вызванном аутоиммунными реакциями, повышенной экспрессией провоспалительных цитокинов, факторов роста, прокоагулянтных факторов, молекул адгезии и снижением высвобождения оксида азота, что приводит к эндотелиальной дисфункции при СД [6,23,27].…”

Section: оксидативный стресс в патофизиологии сд 1-го типаunclassified

“…[17]. Показано, что ОС в первую очередь вызывает эндотелиальную дисфункцию, которая является основным патологическим фундаментом, на котором происходит развитие и прогрессирование осложнений при СД 1-го типа [26]. Сообщалось, что эндотелиальная дисфункция проявляется уже на ранних стадиях у пациентов с данной эндокринопатией, еще до начала клинических проявлений микро-и макрососудистых осложнений [26].…”

Section: роль оксидативного стресса в развитии осложнений при сд 1-го...unclassified

The role of oxidative stress in the pathophysiology of type 1 diabetes mellitus

Быков¹,

Батурин²

2022

Nauchno-Prakticheskii Zhurnal «Patogenez»

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Сахарный диабет (СД) 1-го типа является одной из распространенных эндокринопатий детского возраста. Данное заболевание характеризуется высокой частотой развития острых и хронических осложнений. Несмотря на установленную аутоиммунную природу СД 1-го типа, продолжается поиск новых патофизиологических механизмов развития как самого заболевания, так и его осложнений. Оксидативный стресс (ОС) рассматривается как важная составляющая патогенеза многих заболеваний, в том числе СД 1-го и 2-го типов. ОС представляет собой патологическое состояние, когда скорость образования свободных радикалов превышает возможности антиоксидантной защиты организма, что приводит к токсическому поражению клетки. ОС может быть вовлечен в патогенез СД 1-го типа, за счет повреждения β-клеток поджелудочной железы. ОС играет важную роль в развитии диабетических осложнений за счет запуска процессов аутоокисления глюкозы, нарушения выработки оксида азота и снижения функции антиоксидантных ферментов. Из возможных маркёров ОС на фоне СД 1-го типа рассматриваются: малоновый диальдегид, 8-изо-простагландин F2a, миелопероксидаза, супероксиддисмутаза, глутатионпероксидаза и др. Максимально раннее выявление проявлений ОС у детей с СД 1-го типа может не только помочь вовремя диагностировать диабетические осложнения, но и решать важные профилактические задачи. Своевременная диагностика ОС при СД 1-го типа у детей и подростков также может улучшить терапевтические результаты. Type 1 diabetes mellitus (DM) is one of highly prevalent endocrinopathies of childhood. This disorder is characterized by a high incidence of acute and chronic complications. Although the autoimmune nature of type 1 DM has been established, searches are continuing for new pathophysiological mechanisms underlying both the disease itself and its complications. Oxidative stress (OS) is considered an important pathogenetic component of the development of numerous disorders, including type 1 and 2 DM. OS is a pathological state, in which free radicals are generated at a rate that overwhelms the capacity of the antioxidant defense with resultant toxic damage to cells. OS may be involved in the pathogenesis of type 1 DM by damaging pancreatic β-cells. OS plays an important role in the development of diabetic complications by triggering glucose autoxidation, impairing nitric oxide production, and decreasing antioxidant enzyme activity. Possible OS markers include malonic dialdehyde, 8-iso-prostaglandin F2α, superoxide dismutase, and glutathione peroxidase. The earliest possible detection of OS in children with type 1 DM may help not only to diagnose timely diabetic complications but also to achieve important goals of prevention. Timely detection of OS in children and adolescents with type 1 DM may also improve therapeutic outcomes.

show abstract

Relationship between glucose control, glycemic variability, and oxidative stress in children with type 1 diabetes

Cited by 4 publications

References 31 publications

The Value of Telemedicine for the Follow-up of Patients with New Onset Type 1 Diabetes Mellitus During COVID-19 Pandemic in Turkey: A Report of Eight Cases

The Value of Telemedicine for the Follow-up of Patients with New Onset Type 1 Diabetes Mellitus During COVID-19 Pandemic in Turkey: A Report of Eight Cases

Short-term Glycemic Variability and Its Association With Macrovascular and Microvascular Complications in Patients With Diabetes

The role of oxidative stress in the pathophysiology of type 1 diabetes mellitus

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