Relationship between glucose absorption and villus height in ageing

Jakab, László; Pénzes, L

doi:10.1007/bf01967955

Cited by 21 publications

(7 citation statements)

References 12 publications

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“…This method should be regarded as more reliable than the linear measurements used in some of the previous studies [13,25] which involve the subjective decision as to where the villus ends and the crypt begins [7]. High degrees of subjective involvement imply high levels of interobserver variation [6], which could explain the discrepancy on mean villous height among the controls quoted by Webster and Leaning [25] and those of the more recent studies mentioned above [18,20,22].…”

Section: Discussionmentioning

confidence: 57%

“…Ex perimental studies in rats gave contrasting results as well. Although a progression from finger-shaped villi in neonates to leaf-shaped villi in older animals was noted [2] and a decrease in the height of the villi was assessed morphometrically [13], a recent work did not show any slowing effect of ageing upon intes tinal epithelial cell turnover [11].…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of malab-mental studies showed a decreased rate of sorption in the elderly is often difficult to intestinal epithelial cell proliferation [5. 9] assess [17], which could be ascribed in part to and loss of villous architecture [13,23] with increasing age. Two studies on humans arc compatible with a direct effect of ageing in a reduction of small bowel mucosal surface area [24,25] but both arc liable to criticism mainly for the sampling criteria of the sub jects who underwent jejunal biopsy.…”

Section: Introductionmentioning

confidence: 99%

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Ageing and Small-Bowel Mucosa: A Morphometric Study

Frazzoni¹,

Gatto²,

Gasbarrini³

1986

Gerontology

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A direct effect of ageing in reducing mucosal surface area of the small intestine is still disputed. The aim of this study was to morphometrically evaluate a panel of jejunal biopsy specimens obtained from 16 elderly patients and 22 younger controls, all complaining of abdominal symptoms but without evidence of malabsorption and/or malnutrition in either group. Quantitative histology was performed by calculating the surface area to volume ratio of jejunal mucosa and the mean enterocyte height. The mean of surface to volume ratios in geriatric patients (97.6 ± 18), although slightly reduced, did not significantly differ from that of younger controls (107.6 ± 26) and no significant correlation was found between surface to volume ratio and age in years. The mean enterocyte height in the elderly group (30.1 ± 1.2 μm) did not significantly differ from that of younger controls (31.3 ± 2.3 μm). In conclusion, the frequent finding of malnutrition due to malabsorption in the elderly should not be attributed to a reduction of jejunal surface area as a mere consequence of age.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ageing and Small-Bowel Mucosa: A Morphometric Study

Frazzoni¹,

Gatto²,

Gasbarrini³

1986

Gerontology

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“…Increased microbial infiltration into submucosa and vasculature [180][181][182] Reductions to nutrient ingestion, tolerance of resident microbiota, and the response to infection. [166] Villi morphology changes, decreased cells per villus, decreased mucosal surface area, decreased crypt numbers [174,177,178,[183][184][185] Increased cell apoptosis, reduced cell proliferation and survival, decreased regenerative potential of stem cells [166,177,[184][185][186][187] Disruption of Wnt Signaling [177,[188][189][190] in healthy individuals [166,195]; mechanical properties of mucus have been found to remain stable as well [166].…”

Section: Prominent Aging Phenotypes Referencesmentioning

confidence: 99%

“…In rats, morphological changes such as increased numbers of crypts and villi are observed with aging, although size and cell production rate changes were not observed [ 183 ]. Atrophy of intestinal mucosa also occurs in aged rats and this contributes to decreased number of enterocytes [ 184 , 185 ]. These changes can be localized to specific tissues; for example, mucosal atrophy in rats has been found in proximal regions of the small intestine, but not in the distal small intestine; similarly, the decline in villi height has been found in the ileum but not the duodenum [ 184 ].…”

Section: Demonstrative Organotypic Models Relevant To Aging Tissuementioning

confidence: 99%

Organotypic cultures as aging associated disease models

Sanchez

Bagdasarian

Darch

et al. 2022

Aging

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Aging remains a primary risk factor for a host of diseases, including leading causes of death. Aging and associated diseases are inherently multifactorial, with numerous contributing factors and phenotypes at the molecular, cellular, tissue, and organismal scales. Despite the complexity of aging phenomena, models currently used in aging research possess limitations. Frequently used in vivo models often have important physiological differences, age at different rates, or are genetically engineered to match late disease phenotypes rather than early causes. Conversely, routinely used in vitro models lack the complex tissue-scale and systemic cues that are disrupted in aging. To fill in gaps between in vivo and traditional in vitro models, researchers have increasingly been turning to organotypic models, which provide increased physiological relevance with the accessibility and control of in vitro context. While powerful tools, the development of these models is a field of its own, and many aging researchers may be unaware of recent progress in organotypic models, or hesitant to include these models in their own work. In this review, we describe recent progress in tissue engineering applied to organotypic models, highlighting examples explicitly linked to aging and associated disease, as well as examples of models that are relevant to aging. We specifically highlight progress made in skin, gut, and skeletal muscle, and describe how recently demonstrated models have been used for aging studies or similar phenotypes. Throughout, this review emphasizes the accessibility of these models and aims to provide a resource for researchers seeking to leverage these powerful tools.

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The Gastrointestinal Tract

Holt

1995

Comprehensive Physiology

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The sections in this article are: Salivary Glands Stomach Gastric Secretion Small Intestine Morphology Brush Border Membranes Enzymes Intestinal Permeability Protein Synthesis Intestinal Absorption Gut‐Associated Immune System Splanchnic Blood Flow Gastrointestinal Motility Esophagus Stomach Neuromuscular Functioning Colon and Rectum Pancreas Liver and Biliary Tree Morphology Age‐Associated Effects Consequences of Aging Bile Gastrointestinal Hormones Cellular Proliferation Esophagus and Stomach Small Intestine Colon Effects of Caloric Restriction

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Relationship between glucose absorption and villus height in ageing

Abstract: There is a diminution of D-glucose absorption in the aged rat which is partly due to the decrease of the length of the villi.

Cited by 21 publications

References 12 publications

Ageing and Small-Bowel Mucosa: A Morphometric Study

Ageing and Small-Bowel Mucosa: A Morphometric Study

Organotypic cultures as aging associated disease models

The Gastrointestinal Tract

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