Relationship between glenoid deformity and gait characteristics in a rat model of neonatal brachial plexus injury

Crouch, Dustin L.; Hutchinson, Ian D.; Li, Zhongyu; Saul, Katherine R.

doi:10.1002/jor.23836

Cited by 1 publication

(4 citation statements)

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“…Furthermore, investigating the fidelity with which passive outcomes can predict functional performance in rodents may increase utility of passive performance data and elucidate mechanisms contributing to neuromotor and musculoskeletal deficits. Existing literature on functional movement following BPBI in rodent models includes qualitative reports of altered forelimb posture following preganglionic 8 and postganglionic injury, 13 and quantitative stride and stance metrics following postganglionic injury 14 . The quantitative effects of injury location on functional limb posture and muscle excursion have not been previously studied.…”

Section: Introductionmentioning

confidence: 99%

“…Two potential useful tools for studying functional movement ex vivo are gait analysis and musculoskeletal modeling. Gait analysis can be an effective function‐based quantitative method for studying BPBI in a rat model 14 . Musculoskeletal models provide a framework for integrating anatomical and physiological data, offering insight into the biomechanics underlying movement.…”

Section: Introductionmentioning

confidence: 99%

“…Existing literature on functional movement following BPBI in rodent models includes qualitative reports of altered forelimb posture following preganglionic 8 and postganglionic injury, 13 and quantitative stride and stance metrics following postganglionic injury. 14 The quantitative effects of injury location on functional limb posture and muscle excursion have not been previously studied.…”

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confidence: 99%

“…Gait analysis can be an effective function-based quantitative method for studying BPBI in a rat model. 14 Musculoskeletal models provide a framework for integrating anatomical and physiological data, offering insight into the biomechanics underlying movement. While upper-extremity models have been developed for the human, 15,16 and one hindlimb model has been developed for the rat, 17 the rat forelimb remains unmodeled.…”

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confidence: 99%

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Location of brachial plexus birth injury affects functional outcomes in a rat model

Doshi

Reid

Dixit

et al. 2021

Journal Orthopaedic Research

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Brachial plexus birth injury (BPBI) results in shoulder and elbow paralysis with shoulder internal rotation and elbow flexion contracture as frequent sequelae. The purpose of this study was to develop a technique for measuring functional movement and examine the effect of brachial plexus injury location (preganglionic and postganglionic) on functional movement outcomes in a rat model of BPBI, which we achieved through integration of gait analysis with musculoskeletal modeling and simulation. Eight weeks following unilateral brachial plexus injury, sagittal plane shoulder and elbow angles were extracted from gait recordings of young rats (n = 18), after which rats were sacrificed for bilateral muscle architecture measurements. Musculoskeletal models reflecting animal-specific muscle architecture parameters were used to simulate gait and extract muscle fiber lengths. The preganglionic neurectomy group spent significantly less (p = 0.00116) time in stance and walked with significantly less (p < 0.05) elbow flexion and shoulder protraction in the affected limb than postganglionic neurectomy or control groups. Linear regression revealed no significant linear relationship between passive shoulder external rotation and functional shoulder protraction range of motion. Despite significant restriction in longitudinal muscle growth, normalized functional fiber excursions did not differ significantly between groups. In fact, when superimposed on a normalized force-length curve, neurectomy-impaired muscle fibers (except subscapularis) accessed regions of the curve that overlapped with the control group. Our results suggest the presence of compensatory motor control strategies during locomotion following BPBI. The clinical implications of our findings support emphasis on functional movement analysis in treatment of BPBI, as functional and passive outcomes may differ substantially.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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