Relationship between gestational diabetes and serum trace element levels in pregnant women from Eastern Iran: a multivariate approach

Rezaei, Maryam; Błaszczyk, Martyna; Tinkov, Alexey A.; Binkowski, Łukasz J.; Mansouri, Borhan; Skalny, Anatoly V.; Azadi, Nammam Ali; Doşa, Monica Daniela; Bjørklund, Geir

doi:10.1007/s11356-021-13927-1

Cited by 9 publications

(1 citation statement)

References 66 publications

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“…Although arsenic (As) has been reported to be one of the environmental factors contributing to the increased risk of GDM, − information on the relationship between arsenic species and GDM is very limited. Determining the concentrations of arsenic species in the biospecimen is vital because the toxicity of arsenic species varies greatly. − A small number of epidemiologic studies with varied assessment designs and methods have shown inconsistent results. − The effect of specific arsenic species on GDM is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Association between Arsenic Methylation in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study

Jiang,

Ma,

Zheng

et al. 2023

Environ. Health

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The metabolism of arsenic (As) plays a crucial role in its health effects. However, the impact of arsenic methylation during early pregnancy on gestational diabetes mellitus (GDM) remains unclear. This study aimed to investigate the associations between As methylation in the first and second trimesters and the incidence of GDM by conducting a prospective cohort study in Chongqing, China. Urine samples from first (n = 131) and second (n = 53) trimester pregnant women were analyzed for arsenite (As III ), arsenate (As V ), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations. Logistic regressions assessed associations between the concentrations of As species, methylation indices, and GDM risk. As species concentrations showed no significant differences between GDM and non-GDM groups. Higher MMA% (OR = 1.11; 95% CI = 1.02, 1.22) and lower secondary methylation index (SMI) (OR = 0.81; 95% CI = 0.71, 0.93) correlated with GDM risk, primarily in the first trimester. MMA% decreased and DMA% and SMI increased from the first to the second trimester. Results of stratified analyses revealed these associations in women under 28 or with normal BMIs (18−24 kg/m 2 ). The study underscores inefficient arsenic methylation as a GDM risk, modified by age and BMI, with the first trimester as a critical period.

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