Relationship between genome‐wide and MHC class I and II genetic diversity and complementarity in a nonhuman primate

Petersen, Rachel M.; Bergey, Christina M.; Roos, Christian; Higham, James P.

doi:10.1002/ece3.9346

Cited by 2 publications

(1 citation statement)

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“…We focused on the DRB1 gene, and particularly on exon 2, which contributes to coding the structure of the extracellular antigen-binding region. This gene is exceptionally polymorphic and is the most commonly screened locus in studies of MHC variation in nonhuman primates [30][31][32][33][34][35]. MHC allele calling was performed using the AmpliSAS pipeline [36].…”

Section: Methods (A) Sampling and Laboratory Proceduresmentioning

confidence: 99%

Paternity data reveal high MHC diversity among sires in a polygynandrous, egalitarian primate

Chaves,

Strier,

Di Fiore

2023

Proc. R. Soc. B.

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Evidence from human and nonhuman primates suggests that females avoid breeding with close kin and may choose mates based on MHC diversity, which can improve offspring survival. In despotic societies, female mate choice may be hindered by male sexual coercion, but in egalitarian societies, females may be less constrained. Among northern muriquis—an egalitarian, polygynandrous primate with male philopatry—analyses of new data on paternity and variation at microsatellite and MHC loci, combined with behavioural and life-history data, revealed that sires showed higher MHC diversity than expected by chance and were never close kin of dams, consistent with predictions of female mate choice and close inbreeding avoidance. However, females did not differentially reproduce with males who were more distantly related to them or more dissimilar at the MHC than expected by chance, nor with those who had more MHC alleles distinct from their own. The lack of male dominance may permit females to identify and reproduce preferentially with non-offspring males and with males who are more diverse at the MHC. Nonetheless, the absence of disassortative mating at the MHC and neutral loci suggests that female mate choice may be limited by other factors impacting male fertilization success.

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