Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese

Abstract

ABSTRACT. Dopamine (DA) has been implicated in the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopamine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect gene expression, influence biosynthesis of DA and underlie various neuropsychiatric disorders related to DA dysfunction. The present study explored the association of SNPs within the DRD5 gene with paranoid schizophrenia in Han Chinese. A total of 176 patients with schizophrenia and 206 healthy controls were genotyped for four DRD5 SNPs (rs77434921, rs2076907, rs6283, and rs1800762). Significant group differences were observed in the allele and genotype frequencies of rs77434921 and rs1800762 and in the frequencies of GC haplotypes corresponding to rs77434921-rs1800762. Our findings suggest that common genetic variations of DRD5 are likely to contribute to genetic susceptibility to paranoid schizophrenia in Han Chinese. Further studies in larger samples are needed to replicate this association.

Auxiliary role of D5 dopamine receptor as a marker in paranoid schizophrenia patients

“…The lack of expression in a few of healthy controls may be due to the use of any other drugs or medications and alcohol which indirectly influenced the expression of D5 mRNA that did not consider in this research. Zhao [19] revealed that specific SNPs in D5 dopamine receptor-related with paranoid schizophrenia in male; their investigation was on the genetic risk variant association with paranoid schizophrenia disease and found out D5 dopamine receptor gene in both of regulatory and coding region could affect the gene expression which confirmed our results for lack of D5 mRNA expression [19].…”

Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes

“…Several of these genes have been implicated in anti-psychotic mechanisms of action, including DRD4 (18), HTR1 (34), NTSR1 (31) and ADRA2C (20). mRNA studies in post-mortem brain tissue also showed alterations in PTGER3, S1PR1, ITPR2, EDNRB and SSTR2 (13,25,27), and polymorphisms of DRD5, OPRM1 and CNR1 genes have been associated with susceptibility to schizophrenia (19,23,24). The genetic support from GWAS and other data on sequence variation and from text mining was somewhat less compelling.…”

Potential link between genetic polymorphisms of <em>catechol-O-methyltransferase </em>and dopamine receptors and treatment efficacy of risperidone on schizophrenia

“…According to previously published investigations, we selected potential SNPs, including COMT rs165599, moderately associated with a change in the PANSS Negative score; 22 COMT rs4680, which might be relevant in the differentiation of schizophrenic subtypes; 23 COMT rs165774, involved as a genetic risk factor for schizophrenia; 24 DRD1 rs11746641, associated with protection against the risk of developing schizophrenia; 25 DRD1 rs11749676, supported the role of dopamine dysfunction; 25 DRD2 rs6275, implicated in schizophrenia; 26 DRD2 rs1801028, reported as a risk locus for schizophrenia; 27 DRD2 rs6277, regarded as the only susceptibility factor for schizophrenia; 28 DRD3 rs6280, reported to be associated with altered dopamine binding affinity; 29 and DRD5 rs6283, associated with male paranoid schizophrenia patients. 30 Since these SNPs have been proved to be associated with changes in the PANSS score in published studies, they were selected as genetic targets for schizophrenia in our study. DRD4 was not included as it is rarely marked among the Chinese population.…”