Relationship Between Gastric Emptying Rate and Simultaneously Assessed Symptoms in Functional Dyspepsia

Carbone, Florencia; Buysscher, Rowie De; Houte, Karen Van den; Schol, Jolien; Goelen, Nick; Tack, Jan

doi:10.1016/j.cgh.2021.03.023

Cited by 28 publications

(27 citation statements)

References 40 publications

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“…7 Notably, delayed GET was also associated with worse nausea and vomiting scores. This mirrored a finding in Carbone et al, 8 which evaluated the relationship between GET and symptom severity assessed during gastric emptying breath testing to avoid potential recall biases present in other studies. They studied 504 patients with FD (mean age, 43.6 years; 70% women), of which only 24% had delayed GET.…”

supporting

confidence: 58%

“…Of the 6 symptoms assessed, only nausea was reported at a significantly higher rate in patients with delayed GET. 8 However, the broader association between GET and symptoms was poor.…”

mentioning

confidence: 99%

“…However, severe nausea may be a distinguishing symptom because it is a predominant symptom in GP, and nausea severity was the only symptom associated with delayed GET. 8 Interventional treatments used for GP, such as pyloromyotomy and gastric electrical stimulation, often report improvements in nausea and vomiting despite variable improvements in GET. 18,19 Nausea is also less common in FD and not included in its diagnostic criteria.…”

mentioning

confidence: 99%

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Is It Time to Abandon Gastric Emptying in Patients With Symptoms of Gastroparesis and Functional Dyspepsia?

Chokshi

Chang

2022

Clinical Gastroenterology and Hepatology

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supporting

confidence: 58%

“…Of the 6 symptoms assessed, only nausea was reported at a significantly higher rate in patients with delayed GET. 8 However, the broader association between GET and symptoms was poor.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Is It Time to Abandon Gastric Emptying in Patients With Symptoms of Gastroparesis and Functional Dyspepsia?

Chokshi

Chang

2022

Clinical Gastroenterology and Hepatology

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“…45 Gastric emptying remains an important assessment modality in diabetic gastropathy, but has come under recent controversy due to the inconsistent relationship between emptying rate and symptoms, the lack of resolution of symptoms despite gastric emptying improvements, and the variable repeatability of gastric emptying results over time. 4,46,47 While this study focused on gastric myoelectrical activity and emptying testing was not performed, future studies using both BSGM and gastric emptying simultaneously would be of interest to evaluate how BSGM phenotypes and gastric emptying compare.…”

Section: Discussionmentioning

confidence: 99%

“…1 However, people with diabetes can have disruptive symptoms without gastric emptying abnormalities or may have gastrointestinal symptoms of non-gastric origin, so the more inclusive terminology of ‘diabetic gastroenteropathy’ has been suggested. 2,4…”

Section: Introductionmentioning

confidence: 99%

Defining and phenotyping gastric abnormalities in long-term type 1 diabetes using body surface gastric mapping

Gharibans

Calder

et al. 2022

Preprint

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Objective: To define phenotypes of gastric myoelectrical abnormalities and relation to symptoms in people with longstanding T1D, compared to matched healthy controls, using a novel non-invasive body surface gastric mapping (BSGM) device. Research design and methods: BSGM was performed on people with T1D of >10 years duration and matched controls, employing Gastric Alimetry (Alimetry, New Zealand), comprising a high-resolution 64-channel array, validated symptom logging App, and wearable reader. Results: 32 people with T1D were recruited (15 with a high symptom burden), and 32 controls. Those with symptoms showed more unstable gastric myoelectrical activity, (Gastric Alimetry Rhythm Index 0.39 vs 0.51, p=0.017; and lower average spatial covariance 0.48 vs 0.51, p=0.009) compared with controls. Those with T1D and symptoms also had higher prevalence of peripheral neuropathy (67% vs 6%, p=0.001), anxiety/depression diagnoses (27% vs 0%, p=0.001), and mean HbA1c levels (76 vs 56 mmol/mol, p<0.001). BSGM defined distinct phenotypes in participants including those with markedly unstable gastric rhythms (4/32, 12.5%), and abnormally high gastric frequencies (10/32, 31%). Deviation in gastric frequency was positively correlated with symptoms of bloating, upper gut pain, nausea and vomiting, and fullness and early satiation (r>0.35, p<0.05) Conclusion: Gastroduodenal symptoms in people with longstanding T1D correlate with gastric myoelectrical abnormalities on BSGM evaluation, in addition to glycemic control, psychological comorbidities, and peripheral neuropathy. BSGM using the Gastric Alimetry device identified a range of myoelectrical phenotypes, representing both myogenic and neurogenic mechanisms, which represent targets for diagnosis, monitoring and therapy.

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Risk Factors and Outcomes for Gastroparesis After Lung Transplantation

et al. 2021

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Relationship Between Gastric Emptying Rate and Simultaneously Assessed Symptoms in Functional Dyspepsia

Cited by 28 publications

References 40 publications

Is It Time to Abandon Gastric Emptying in Patients With Symptoms of Gastroparesis and Functional Dyspepsia?

Is It Time to Abandon Gastric Emptying in Patients With Symptoms of Gastroparesis and Functional Dyspepsia?

Defining and phenotyping gastric abnormalities in long-term type 1 diabetes using body surface gastric mapping

Risk Factors and Outcomes for Gastroparesis After Lung Transplantation

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