Relationship between gadolinium-based MRI contrast agent consumption and anthropogenic gadolinium in the influent of a wastewater treatment plant

Laczovics, Attila; Csige, I.; Szabó, Sándor; Tóth, Ádám; Kálmán, Ferenc K.; Tóth, I.; Fülöp, Zoltán; Berényi, Ervin; Braun, Mihály

doi:10.1016/j.scitotenv.2023.162844

Science of The Total Environment

2023

DOI: 10.1016/j.scitotenv.2023.162844

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Relationship between gadolinium-based MRI contrast agent consumption and anthropogenic gadolinium in the influent of a wastewater treatment plant

Attila Laczovics

I. Csige

Sándor Szabó

et al.

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Cited by 5 publications

(1 citation statement)

References 38 publications

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“…In addition, there is growing concern about the environmental impact of GBCAs by contaminating the aquatic environment after excretion by the patients 19,20 …”

mentioning

confidence: 99%

A Comprehensive Overview of the Efficacy and Safety of Gadopiclenol: A New Contrast Agent for MRI of the CNS and Body

Hao,

Pitrou,

Bourrinet

2023

Invest Radiol

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This review describes the pharmacokinetics, efficacy, and safety of gadopiclenol, a new macrocyclic gadolinium-based contrast agent (GBCA) recently approved by the Food and Drug Administration at the dose of 0.05 mmol/kg. Gadopiclenol is a high relaxivity contrast agent that shares similar pharmacokinetic characteristics with other macrocyclic GBCAs, including a predominant renal excretion. In pediatric patients aged 2–17 years, the pharmacokinetic parameters (assessed through a population pharmacokinetics model) were comparable to those observed in adults, indicating no need for age-based dose adjustment. For contrast-enhanced magnetic resonance imaging (MRI) of the central nervous system (CNS) and body indications, gadopiclenol at 0.05 mmol/kg was shown to be noninferior to gadobutrol at 0.1 mmol/kg in terms of 3 lesion visualization parameters (ie, lesion border delineation, internal morphology, and contrast enhancement). Moreover, for contrast-enhanced MRI of the CNS, compared with gadobenate dimeglumine at 0.1 mmol/kg, gadopiclenol exhibited superior contrast-to-noise ratio at 0.1 mmol/kg and comparable contrast-to-noise ratio at 0.05 mmol/kg. A pooled safety analysis of 1047 participants showed a favorable safety profile for gadopiclenol. Comparative studies showed that the incidence and nature of adverse drug reactions with gadopiclenol were comparable to those observed with other GBCAs. Importantly, no significant safety concerns were identified in pediatric and elderly patients, as well as in patients with renal impairment. Overall, these findings support the clinical utility and safety of gadopiclenol for MRI in adult and pediatric patients aged 2 years and older in CNS and body indications.

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“…In addition, there is growing concern about the environmental impact of GBCAs by contaminating the aquatic environment after excretion by the patients 19,20 …”

mentioning

confidence: 99%

A Comprehensive Overview of the Efficacy and Safety of Gadopiclenol: A New Contrast Agent for MRI of the CNS and Body

Hao,

Pitrou,

Bourrinet

2023

Invest Radiol

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Anthropogenic gadolinium contaminations in the marine environment and its ecological implications

Zhang,

Jiang,

et al. 2024

Environmental Pollution

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Distribution of rare earth elements and assessment of anthropogenic gadolinium in estuarine habitats: The case of Loire and Seine estuaries in France

Rétif,

Briant,

Zalouk-Vergnoux

et al. 2024

Science of The Total Environment

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Relationship between gadolinium-based MRI contrast agent consumption and anthropogenic gadolinium in the influent of a wastewater treatment plant

Cited by 5 publications

References 38 publications

A Comprehensive Overview of the Efficacy and Safety of Gadopiclenol: A New Contrast Agent for MRI of the CNS and Body

A Comprehensive Overview of the Efficacy and Safety of Gadopiclenol: A New Contrast Agent for MRI of the CNS and Body

Anthropogenic gadolinium contaminations in the marine environment and its ecological implications

Distribution of rare earth elements and assessment of anthropogenic gadolinium in estuarine habitats: The case of Loire and Seine estuaries in France

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