Relationship between functional connectivity and sensory impairment: Red flag or red herring?

Dinomais, Mickaël; Groeschel, Samuel; Staudt, Martin; Krägeloh‐Mann, Ingeborg; Wilke, Marko

doi:10.1002/hbm.21227

Cited by 31 publications

(31 citation statements)

References 53 publications

(87 reference statements)

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“…5 The resulting modulation may influence the somatosensory systems through network connectivity in children with congenital onset stroke depending on stimulation parameters, orientation of the TMS coil, and reorganization patterns. 6 Investigation of translational clinical outcomes of NIBS in pediatrics is only recently developing; therefore the full impact and long-term outcomes on cognition, motor, and sensibility are not known. Paired interventions (such as CIMT and NIBS) aim to improve hand function including somatosensory processing.…”

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confidence: 99%

Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement therapy clinical trial

Rich

Cassidy

Menk

et al. 2016

Developmental Neurorehabilitation

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Objective Poor sensibility affecting stereognosis, the ability to discriminate objects without visual input, can potentiate disuse of the paretic limb following stroke. The purpose of this study was to examine potential change in stereognosis after intervention. Methods Stereognosis testing in a secondary subgroup of 10 children with hemiparesis and baseline stereognosis deficits (ages 11–16) after a 13-day clinical trial of real or sham repetitive transcranial magnetic stimulation (rTMS) and constraint-induced movement therapy (CIMT) is reported. All children received 10 h of CIMT while wearing a cast full-time. Results Post-trial, 80% of participants from both intervention groups demonstrated improvement in stereognosis (95% CI: 44.4%–97.5%). Pre-trial to long-term follow-up (range: 21–57 months), 60% retained gains or improved (95% CI: 26.2%–87.8%). Between-group differences were not detected. Discussion Children demonstrated stereognosis change following intervention. Research on this change and potential minimal clinically important differences are indicated.

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confidence: 99%

Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement therapy clinical trial

Rich

Cassidy

Menk

et al. 2016

Developmental Neurorehabilitation

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“…As discussed by Park and Friston [], a network is not a simple combination of individual pathways, but rather, a systematic organization of interactions within the network. Thus, an altered corticospinal pathway or thalamocortical pathway found in previous studies on CP [Arzoumanian et al, ; Lee et al, ; Pannek et al, ; Scheck et al, ; Thomas et al, ] or altered functional connectivity in CP [Dinomais et al, ; Lee et al, ; Papadelis et al, ] may not be sufficient enough to explain the topological architecture of the motor‐related brain regions, including cortical and subcortical regions. What is more important might be the nature of circuits and a combination of edges [Marder, ].…”

Section: Discussionmentioning

confidence: 96%

Analysis of structure–function network decoupling in the brain systems of spastic diplegic cerebral palsy

Lee

Pae

Lee

et al. 2017

Human Brain Mapping

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Manifestation of the functionalities from the structural brain network is becoming increasingly important to understand a brain disease. With the aim of investigating the differential structure-function couplings according to network systems, we investigated the structural and functional brain networks of patients with spastic diplegic cerebral palsy with periventricular leukomalacia compared to healthy controls. The structural and functional networks of the whole brain and motor system, constructed using deterministic and probabilistic tractography of diffusion tensor magnetic resonance images and Pearson and partial correlation analyses of resting-state functional magnetic resonance images, showed differential embedding of functional networks in the structural networks in patients. In the whole-brain network of patients, significantly reduced global network efficiency compared to healthy controls were found in the structural networks but not in the functional networks, resulting in reduced structural-functional coupling. On the contrary, the motor network of patients had a significantly lower functional network efficiency over the intact structural network and a lower structure-function coupling than the control group. This reduced coupling but reverse directionality in the whole-brain and motor networks of patients was prominent particularly between the probabilistic structural and partial correlation-based functional networks. Intact (or less deficient) functional network over impaired structural networks of the whole brain and highly impaired functional network topology over the intact structural motor network might subserve relatively preserved cognitions and impaired motor functions in cerebral palsy. This study suggests that the structure-function relationship, evaluated specifically using sparse functional connectivity, may reveal important clues to functional reorganization in cerebral palsy. Hum Brain Mapp 38:5292-5306, 2017. © 2017 Wiley Periodicals, Inc.

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“…The relationship between functional connectivity, sensory deficits, and structural abnormality remains poorly understood [33]. However, to our knowledge, rs-fMRI data for children with stroke are limited and refer only to the somatosensory system.…”

Section: Introductionmentioning

confidence: 99%

“…However, to our knowledge, rs-fMRI data for children with stroke are limited and refer only to the somatosensory system. Dinomais et al [33] have investigated rs-fMRI in perinatal stroke patients with cortical and periventricular lesions and demonstrated a relationship between functional connectivity and somatosensory impairment. Children who had lesions in the MCA territory displayed significantly less functional connectivity in the somatosensory cortex than children with periventricular lesions [33].…”

Section: Introductionmentioning

confidence: 99%

“…Dinomais et al [33] have investigated rs-fMRI in perinatal stroke patients with cortical and periventricular lesions and demonstrated a relationship between functional connectivity and somatosensory impairment. Children who had lesions in the MCA territory displayed significantly less functional connectivity in the somatosensory cortex than children with periventricular lesions [33]. Recently, a small group of children with spastic cerebral palsy [34] and another group of hemiplegic cerebral palsy after cortical and subcortical damage [35] were investigated with rs-fMRI without data about the vascular origin of the damage.…”

Section: Introductionmentioning

confidence: 99%

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Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke

Ilves

Laugesaar

et al. 2016

Neural Plasticity

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Perinatal stroke is a leading cause of congenital hemiparesis and neurocognitive deficits in children. Dysfunctions in the large-scale resting-state functional networks may underlie cognitive and behavioral disability in these children. We studied resting-state functional connectivity in patients with perinatal stroke collected from the Estonian Pediatric Stroke Database. Neurodevelopment of children was assessed by the Pediatric Stroke Outcome Measurement and the Kaufman Assessment Battery. The study included 36 children (age range 7.6–17.9 years): 10 with periventricular venous infarction (PVI), 7 with arterial ischemic stroke (AIS), and 19 controls. There were no differences in severity of hemiparesis between the PVI and AIS groups. A significant increase in default mode network connectivity (FDR 0.1) and lower cognitive functions (p < 0.05) were found in children with AIS compared to the controls and the PVI group. The children with PVI had no significant differences in the resting-state networks compared to the controls and their cognitive functions were normal. Our findings demonstrate impairment in cognitive functions and neural network profile in hemiparetic children with AIS compared to children with PVI and controls. Changes in the resting-state networks found in children with AIS could possibly serve as the underlying derangements of cognitive brain functions in these children.

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Relationship between functional connectivity and sensory impairment: Red flag or red herring?

Cited by 31 publications

References 53 publications

Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement therapy clinical trial

Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement therapy clinical trial

Analysis of structure–function network decoupling in the brain systems of spastic diplegic cerebral palsy

Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke

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