Relationship between foot vibration threshold and walking and balance functions in people with Multiple Sclerosis (PwMS)

Uszynski, Marcin; Purtill, Helen; Coote, Susan

doi:10.1016/j.gaitpost.2014.10.010

Cited by 15 publications

(14 citation statements)

References 24 publications

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“…This query has been proven in various studies confirming that the loss of sensation on the sole negatively affects gait in the MS population [18,19]. However, we acknowledge that PwMS who suffer only from sensory loss have improved gait compared to those affected in the pyramidal system.…”

Section: Discussionsupporting

confidence: 70%

Gait characteristics according to pyramidal, sensory and cerebellar EDSS subcategories in people with multiple sclerosis

Kalron

Givon

2016

J Neurol

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Walking deterioration is a common problem in people with multiple sclerosis (PwMS). However, there are only scarce data examining the contribution of specific neurological functional systems on gait performance in multiple sclerosis (MS). Therefore, the objective of the current study was to examine the differences in spatio-temporal parameters of gait according to the pyramidal, cerebellar and sensory functional systems. The cross-sectional study included 289 PwMS with mean disease duration of 8.0 (SD = 8.2) years. Spatio-temporal parameters of gait were studied using an electronic walkway. The sample pool was divided into six groups according to the scores of the pyramidal, cerebellar and sensory functional systems, derived from the expanded disability status scale data. Findings indicated that asymmetry of the step time and asymmetry of the single support were significantly elevated in the pyramidal group compared to the sensory group; 9.4 (SD = 10.6) vs. 3.1 (SD = 6.7), P value = 0.004; 9.3 (SD = 10.4) vs. 2.7 (2.1), P value = 0.001, respectively. Additionally, patients in the pure sensory group walked significantly faster with longer strides and less asymmetry compared to the pyramidal-cerebellar-sensory group. Moreover, patients in the sensory group walked with longer steps/strides and symmetry compared to the patients in the pyramidal-cerebellar group. This study confirms that pyramidal disorders are main contributors of gait impairments in the MS population. Furthermore, patients with sensory impairments have a relatively preserved gait pattern compared to patients affected by the pyramidal system.

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Section: Discussionsupporting

confidence: 70%

Gait characteristics according to pyramidal, sensory and cerebellar EDSS subcategories in people with multiple sclerosis

Kalron

Givon

2016

J Neurol

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“…Vibratory sensation has been shown to distinguish among individuals with MS with and without walking impairment, and greater postural sway (i.e., proprioceptive impairment) has been linked with cerebellar and spinal cord atrophy . Our results show that vibration sensation among subtypes was significantly different, with individuals in the progressive cohort having worse vibratory sensation (Table ), which is in agreement with previous work from our laboratory .…”

Section: Discussionsupporting

confidence: 91%

“…Proprioception and vibration sensation, both carried by the dorsal columns, are frequently impaired in MS . Proprioceptive input contributes to balance impairment, postural control, and falls; similarly, vibratory sensation is linked with balance and walking speed . Our group has linked tract‐specific measures of the dorsal columns, spinal cord, and peripapillary retinal nerve fiber layer with vibratory sensation thresholds in MS.…”

Section: Introductionmentioning

confidence: 96%

Quantitative vibratory sensation measurement is related to sensory cortical thickness in MS

Fritz

Eloyan

Glaister

et al. 2019

Ann Clin Transl Neurol

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Objective Vibratory sensation is a quantifiable measure of physical dysfunction and is often related to spinal cord pathology; however, its association with relevant brain areas has not been fully explored. Our objective was to establish a cortical structural substrate for vibration sensation. Methods Eighty‐four individuals with multiple sclerosis (MS) (n = 54 relapsing, n = 30 progressive) and 28 controls participated in vibratory sensation threshold quantification at the great toe and a 3T MRI evaluating volume of the thalamus and cortical thickness primary and secondary sensory cortices. Results After controlling for age, sex, and disability level, vibratory sensation thresholds were significantly related to cortical thickness of the anterior cingulate (P = 0.041), parietal operculum (P = 0.022), and inferior frontal gyrus pars operculum (P = 0.044), pars orbitalis (P = 0.007), and pars triangularis (P = 0.029). Within the progressive disease subtype, there were significant relationships between vibratory sensation and thalamic volume (P = 0.039) as well as reduced inferior frontal gyrus pars operculum (P = 0.014) and pars orbitalis (P = 0.005) cortical thickness. Conclusions The data show significant independent relationships between quantitative vibratory sensation and measures of primary and secondary sensory cortices. Quantitative clinical measurement of vibratory sensation reflects pathological changes in spatially distinct brain areas and may supplement information captured by brain atrophy measures. Without overt relapses, monitoring decline in progressive forms of MS has proved challenging; quantitative clinical assessment may provide a tool to examine pathological decline in this cohort. These data suggest that quantitative clinical assessment may be a reliable way to examine pathological decline and have broader relevance to progressive forms of MS.

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“…To our knowledge, only one study so far, by Newsome et al, 5 has investigated the interrater reliability of the vibration threshold in people with MS, using the Vibratron II (Physitemp Instruments Inc, Clifton, NJ), and also found good reliability. In a previous study, 13 we reported the relationship between foot vibration threshold and clinical measures of walking and balance in people with MS and the predictive validity of foot vibration threshold. Additionally, we found good 43 where poor-to-moderate interrater reliability was reported in healthy participants, and by Rozental et al, 44 where fair-to-slight reliability was reported in asymptomatic individuals with peripheral nerve injuries and compression syndromes.…”

Section: Average (Fifth Mtpj)mentioning

confidence: 99%

“…The assessment of sensory impairment is not common in clinical practice, but it is clear that sensation plays an important role in motor control 11,12 and is related to gait and balance function in people with MS. 13 However, there is little research into how exercise and rehabilitation affect the sensory system; one possible reason for this is the lack of information on valid and reliable assessments.…”

mentioning

confidence: 99%

Interrater Reliability of Four Sensory Measures in People with Multiple Sclerosis

Uszynski¹,

Purtill²,

Coote³

2016

International Journal of MS Care

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Background: Sensory disturbances are a major problem for people with multiple sclerosis (MS), and up to 80% of people with MS present with various sensory deficits. To date, only one study has investigated the reliability of sensory measures in people with MS. We sought to determine the interrater reliability of the verbal analogue scale (VAS), the Erasmus MC modifications to the revised Nottingham Sensory Assessment (EmNSA), Semmes-Weinstein monofilaments (SWMs), and the neurothesiometer (NT) in people with MS.

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Relationship between foot vibration threshold and walking and balance functions in people with Multiple Sclerosis (PwMS)

Cited by 15 publications

References 24 publications

Gait characteristics according to pyramidal, sensory and cerebellar EDSS subcategories in people with multiple sclerosis

Gait characteristics according to pyramidal, sensory and cerebellar EDSS subcategories in people with multiple sclerosis

Quantitative vibratory sensation measurement is related to sensory cortical thickness in MS

Interrater Reliability of Four Sensory Measures in People with Multiple Sclerosis

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