Relationship between follicular volume and oocyte competence, blastocyst development and live‐birth rate: optimal follicle size for oocyte retrieval

Abstract

Objective To analyze oocyte competence in gonadotropinreleasing hormone agonist (GnRHa)

Inhibin A—A Promising Predictive Parameter for Determination of Final Oocyte Maturation in Ovarian Stimulation for IVF/ICSI

“…Current literature suggests that follicles of sizes 16-22 mm on the day of oocyte retrieval contribute the most to the number of oocytes retrieved and that oocytes, derived from medium size follicles (13-23 mm), have equal maturity rates, fertilization rates, and blastocyst development compared to oocytes from large size follicles (≥23 mm). These rates were significantly lower for oocytes obtained from small follicles (8-12 mm) (33)(34)(35). Follicle growth is assumed to occur at a pace of ∼1.7 mm/day, theoretically resulting in a follicle size at the time of trigger administration, 34-38 h prior oocyte retrieval procedure, of 12-18 mm.…”

Prognostic value of oocyte quality in assisted reproductive technology outcomes: a systematic review

“…In the last 10 years, we identified 11 articles investigating the prognostic value of oocyte and follicle morphological features in predicting reproductive outcomes. Six articles studied meiotic spindle quality (9-14), 1 article investigated telomere length ( 15), 1 study measured polar body morphology ( 16), 1 article assessed the zona pellucida ( 14), 1 study measured the combined effect of several morphological features (17), and 2 articles assessed the prognostic value of overall follicular size (18,19).…”

“…However, it currently remains unclear whether follicle size is a valuable predictor of the quality of the associated oocyte (18). Two studies, by McCulloh et al (18) and Wirleitner et al (19), set out to prospectively investigate the role of overall follicular size in predicting reproductive outcomes. McCulloh et al (18) examined 317 oocytes from 22 donors.…”

Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages

“…Oocyte maturation is associated with follicle size; therefore, the size of the follicle on the day of oocyte retrieval is one of the determinants of oocyte maturation [8]. Research has shown that the oocyte recovery rate from small follicles (8-12 mm) at oocyte retrieval is significantly lower than that of medium (13-23 mm) and large (≥ 24 mm) follicles [9], which means that the larger the follicle, the higher the oocyte recovery rate, and therefore the greater the chance of mature oocytes being obtained. However, it has not been determined whether the metabolite components in the FF at different developmental stages from the same background are different.…”