Relationship Between Flare and Health-related Quality of Life in Patients with Systemic Lupus Erythematosus

Zhu, Tracy Y.; Tam, Lai‐Shan; Lee, Vivian; Lee, Kenneth K.; Li, Edmund K.

doi:10.3899/jrheum.090876

Cited by 49 publications

(37 citation statements)

References 24 publications

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“…Active musculoskeletal and renal lupus had a negative influence on most SF-36 dimensions. The impacts of SLE musculoskeletal and renal involvements on HRQoL have been previously reported: In a retrospective study of 303 patients, musculoskeletal flares in the preceding year were independently associated with impairment of most of the subscales of the SF-36, except role limitation due to physical problems and mental health [29]. This is in contrast with our findings, where active musculoskeletal involvement also impaired physical role and mental health, but had no significant effect on physical functioning, general health and vitality.…”

Section: Discussionmentioning

confidence: 99%

Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)

et al. 2017

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BackgroundTo assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE).MethodsCross-sectional study of patients included in the Swiss SLE Cohort Study between April 2007 and June 2014. HRQoL outcomes were based on the Medical Outcome Study Short Form 36 (SF-36). Disease activity was assessed by the SLE Disease Activity Index score with the Safety of Estrogens in SLE National Assessment modification (SELENA-SLEDAI) and by the physican’s global assessment (PGA).ResultsOf the 252 patients included, 207 (82%) were women. Median [interquartile range (IQR)] age was 43 [32–57] years. SLE was active in 125 patients (49.6%). Median [IQR] mental component summary (MCS) in active vs inactive SLE was 40.0 [30.2–51.0] compared to 47.3 [39.2–52.8] (p < 0.01) and median [IQR] physical component summary (PCS) 43.7 [37.0–52.8] compared to 49.1 [38.4–55.6], respectively (p < 0.05). Increase in SELENA-SLEDAI or increase in PGA were negatively correlated with PCS and/or MCS. After adjusting for gender, age and disease duration, disease activity impacted on both PCS and MCS and all subscales except general health. Active lupus nephritis and musculoskeletal involvement were associated with physical limitations and emotional problems, increased bodily pain and poor social functioning. Low complement and/or presence of anti-dsDNA antibodies were associated with increased fatigue and reduced mental health.ConclusionsIn patients with SLE, HRQoL is reduced in those with active disease. Impact of disease activity on HRQoL dimensions depends on SELENA-SLEDAI system components.Electronic supplementary materialThe online version of this article (doi:10.1186/s12865-017-0200-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)

et al. 2017

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“…Previous research has established flares as important determinants of the humanistic and economic burdens of SLE 27,36 . As identified by the flare severity algorithm, flares were common in the studied population, with more than 95% of patients having at least one flare over the 2-year follow-up period.…”

Section: Discussionmentioning

confidence: 99%

Healthcare utilization and cost of systemic lupus erythematosus in a US managed care health plan

Garris

Jhingran

Bass

et al. 2013

Journal of Medical Economics

148

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“…High pain levels that interfere with quality of life are a primary concern for patients with SLE (1,2). In addition to high levels of pain, patients with SLE also experience significant stiffness, fatigue, and psychological distress (3)(4)(5); all are symptoms that are inadequately affected by current immunomodulatory therapies for SLE.…”

Section: Introductionmentioning

confidence: 99%

Self‐efficacy and pain catastrophizing in systemic lupus erythematosus: Relationship to pain, stiffness, fatigue, and psychological distress

Somers¹,

Kurakula²,

Criscione-Schreiber³

et al. 2012

Arthritis Care & Research

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Objective. To determine how self-efficacy for pain control and pain catastrophizing, both potentially modifiable pain coping cognitions, are related to pain, stiffness, fatigue, and psychological distress in patients with systemic lupus erythematosus (SLE). Methods. We conducted a cross-sectional study of patients with SLE who completed measures of pain coping cognitions (i.e., self-efficacy for pain control, pain catastrophizing), symptom ratings (i.e., pain, stiffness, fatigue), and psychological distress. Results. Correlational analyses revealed that self-efficacy for pain control and pain catastrophizing were associated with the patients' physical symptom reports and psychological distress. After controlling for age, race, and disease activity, patients with lower levels of self-efficacy for pain control reported much higher levels of pain, stiffness, and fatigue. Patients with higher levels of pain catastrophizing reported much lower positive mood. SLE activity as assessed by the rheumatologist was not associated with physical symptoms, psychological distress, self-efficacy for pain control, or pain catastrophizing. Conclusion. These results suggest that pain coping cognitions (i.e., either self-efficacy for pain control or pain catastrophizing) are significantly related to physical symptoms and psychological distress in patients with SLE. This finding is important because the results of studies from other samples of patients with persistent pain conditions have shown that these pain coping variables can be modified using psychological interventions, and that such treatment-related changes in pain cognitions are related to improved patient outcomes.

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Relationship Between Flare and Health-related Quality of Life in Patients with Systemic Lupus Erythematosus

Abstract: The low level of patients' HRQOL is mostly associated with the presence of musculoskeletal involvement.

Cited by 49 publications

References 24 publications

Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)

Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)

Healthcare utilization and cost of systemic lupus erythematosus in a US managed care health plan

Self‐efficacy and pain catastrophizing in systemic lupus erythematosus: Relationship to pain, stiffness, fatigue, and psychological distress

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