Relationship Between Fetal Hypoxia and Endothelin-1 in Fetal Circulation

Hashiguchi, Kazunari; Takagi, Kaoru; Nakabayashi, Masao; Takeda, Yasuhiko; Sakamoto, S.; Naruse, Masahiro; Naruse, Kiyoko; Demura, Hiroshi

doi:10.1097/00005344-199100177-00145

Cited by 21 publications

(9 citation statements)

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“…Hashiguchi et al showed a relation between fetal hypoxia and fetal endothelin 1 concentrations. 8 They showed that the mean plasma concentration of endothelin 1 in umbilical venous blood with a pH below 7.30 was significantly higher than that in samples with a pH above 7.30. This finding is in accordance with our results; cord blood pH was below 7.30 in most of the patients with MSAF, although endothelin 1 concentrations in cord blood were not measured in our study.…”

Section: Discussionmentioning

confidence: 98%

Endothelin 1 concentrations in infants with meconium stained amniotic fluid

Yiğit

Tekinalp

Oran

et al. 2002

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Section: Discussionmentioning

confidence: 98%

Endothelin 1 concentrations in infants with meconium stained amniotic fluid

Yiğit

Tekinalp

Oran

et al. 2002

Archives of Disease in Childhood - Fetal and Neonatal Edition

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“…Roth of these events may contribute to the morphological and functional ab normalities of POPV. Binding sites and mRNA for ET-1 receptors have been reported on the muscular layer of pul monary arteries and airways [14,15], ET-1 like immunoreactivity (ET-l-IR) and mRNA have been detected in normal lungs of several species [16][17][18], ET-1 levels have been shown to increase under several pathological condi tions such as hypoxia [6,19], coronary artery disease [20], cardiogenic shock [21], and pulmonary hypertension [22], Furthermore, we have recently reported an increase of ET-1 expression in lungs of patients with pulmonary hypertension, especially over the endothelium of muscu lar pulmonary arteries [23].…”

Section: Introductionmentioning

confidence: 99%

Endothelin-1-Like Immunoreactivitγ in Postobstructive Pulmonary Vasculopathy

Giaid

Stewart²,

Michel³

1993

J Vasc Res

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Postobstructive pulmonary vasculopathy (POPV) is produced by chronic ligation of one pulmonary artery and results in bronchial collateral vessel proliferation and pulmonary arterial abnormalities. The role of endothelin-1 (ET-1), a potent vasoconstrictor peptide, was investigated in a canine model of POPV using radioimmunoassay and immunohistochemistry. The left main pulmonary artery of 9 dogs was ligated, and 3 months (n = 3) and 15 months (n = 6) later, ET-1 levels were measured by radioimmunoassay of plasma samples from left and right pulmonary arteries and veins. In addition, tissues from control and ligated lungs were fixed in Bouin’s solution embedded in paraffin and stained with antiserum to ET-1. Plasma ET-1 levels distal to the ligation were not different from those of the control pulmonary artery (1.7 pg/ml in the ligated lungs vs. 1.4 pg/ml in the controls; NS). ET-1-like immunoreactivity was localized mainly to the epithelium in both control and ligated lungs, but the pulmonary arteries and the new bronchial vessels stained more intensely in the ligated lungs. The sections immunostained with ET-1 antiserum preab-sorbed with synthetic ET-1 did not stain. These results suggest that ET-1 may play a role in the bronchial neovascularization and the pulmonary arterial thickening characteristic of POPV.

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“…The redistribution of fetal cardiac output during hypoxia may be partially dependent on the reported increased circulating levels of several vasoactive factors, including norepinephrine (14,43) and endothelin-1 (1,19), but may also involve changes in the local vascular responses to these circulating factors. The effects of chronic hypoxia in utero on the regional vascular responses to these vasoconstrictors after birth are not yet known.…”

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confidence: 99%