Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study

Abstract

Hypertriglyceridemic waist phenotype (HTWP) and its quantitative indicator, waist circumference-triglyceride index (WTI), are common quantitative indices of visceral obesity and are closely related to metabolic diseases. The purpose of this study was to investigate the relationship between fatty pancreas (FP) and HTWP in China. FP was diagnosed using trans-abdominal ultrasonography in all participants. According to the waist circumference and serum triglyceride levels, the participants were divided into four phenotype groups: normal waist circumference-normal triglyceride, normal waist circumference-elevated triglyceride, elevated waist circumference-normal triglyceride, and elevated waist circumference-elevated triglyceride (indicating HTWP). Clinical characteristics and biochemical indices were compared among the groups. Receiver operating characteristic (ROC) curves were used to evaluate the utility of WTI as a reference factor for FP screening. The HTWP group had a higher prevalence of metabolic syndrome (84.2%), FP (10.4%), fatty liver (64.5%), and hypertension (15.8%) than the other three phenotype groups. The occurrence rate of HTWP and the median WTI were significantly higher in participants with FP than in those without FP (54.7% vs 21.0%, 222 ± 135 vs 142 ± 141, p < 0.001). In the ROC curve analysis, when the maximum area under the curve was 0.746, the WTI was 107.09 and the corresponding sensitivity and specificity were 90.6% and 51.9%, respectively. HTWP is closely associated with FP and can be used as a reference factor for FP screening.

Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study

“…For example, Jaghutriz et al 31 who assessed the metabolomic characteristics of fatty pancreas in prediabetics identified as association between NAFPD and obesity. Also, Sotoudehmanesh et al 29 and Yu et al 32 found an association between NAFPD and dyslipidemia. Furthermore, Chiyanika et al 34 reported a significant association between NAFPD and MetS in obese adolescents.…”

Fatty pancreas was associated with a higher acute pancreatitis Systemic Inflammatory Response Syndrome score at hospital admission

“…The limitations of our study are its single center and retrospective study design, and that there were no differences in BMI and obesity between the two groups, despite the fact that fatty pancreas was shown to be associated with obesity, mainly central visceral obesity, and hypertriglyceridemia [35]. In our study, we had data regarding BMI and obesity in general but not concerning central obesity, and this is likely to have contributed to the similar rate of obesity we recorded between the two groups.…”

Hypertriglyceridaemic waist phenotype and waist circumference triglyceride index are associated with higher incidence of acute pancreatitis: a nationwide population-based retrospective cohort study

“… 30 Another study also reported that the HTGW phenotype was associated with systemic inflammatory response syndrome, organ failure and severity of AP. 31 In addition, there is research showing that the HTGW phenotype is closely related to fatty pancreas, 32 suggesting that visceral obesity and fatty pancreas may be related to AP in some way. There are several hypotheses that can explain the correlation between the HTGW phenotype, and the incidence of AP.…”