Relationship between fasting plasma glucose, atherosclerosis risk factors and carotid intima media thickness in non-diabetic individuals

Temelkova‐Kurktschiev, Theodora; Koehler, Carsta; Schäper, Frank; Henkel, Elena; Hahnefeld, Anton; Fuecker, Katja; Siegert, Gabriele; Hanefeld, Markolf

doi:10.1007/s001250050972

Cited by 70 publications

(62 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mild hyperglycaemia [8,11,48], increased postprandial plasma glucose concentrations [12] and slight increases in HbA 1c [49] have been associated with increased carotid IMT in non-diabetic subjects. In crosssectional studies in patients with Type I diabetes, associations between HbA 1c and mean carotid IMTs have been found [14,17].…”

Section: Discussionmentioning

confidence: 99%

“…In non-diabetic subjects, age, male gender, hypertenThe mortality and morbidity from cardiovascular disease is two to four times higher in patients with Type I sion, smoking, impaired fibrinolysis, hypercholesterolaemia, and mild hyperglycaemia seem to be independent predictors of IMT [7,8,9,10,11,12]. In cross-sectional studies, carotid IMT has been increased in Type I diabetic patients compared with matched control subjects [13] already at a young age [14], and in the absence of overt macrovascular disease [15].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Family histories of Type II diabetes and hypertension predict intima–media thickness in patients with Type I diabetes

et al. 2002

View full text Add to dashboard Cite

Aims/hypothesis. Hyperglycaemia predicts microvascular complications but data on macrovascular disease are limited. We searched for predictors of carotid artery intima-media thickness in young adults with Type I (insulin-dependent) diabetes mellitus. Methods. A total of 71 children (F/M = 34/37) were followed after their diagnosis until they reached 32 ± 1 years of age, when duration of diabetes averaged 22 ± 1 years. Cardiovascular risk markers [lipids, blood pressure, smoking, urinary albumin excretion rate, lifetime glycaemic exposure (A 1c months), exercise habits, alcohol consumption, family history] were evaluated at age 21 ± 1 for the baseline examination and at age 32 ± 1 years for the follow-up examination years. During follow-up, intima-media thickness of common and internal carotid arteries and the carotid bulb were quantitated using a high-resolution B-mode ultrasound.Results. In univariate analysis, age, BMI, blood pressure, lifetime glycaemic exposure, a positive family history of Type II (non-insulin-dependent) diabetes mellitus, hypertension and cardiovascular disease were predictors of carotid intima-media thickness. In multivariate analysis, a positive family history of Type II diabetes predicted maximal (p < 0.05) and common (p < 0.005) carotid artery intima-media thickness, family history of hypertension predicted increases in maximal (p < 0.04), and far wall (p < 0.006) carotid artery intima-media thickness, and lifetime glycaemic exposure was an independent predictor of increased carotid bulb thickness (p < 0.03). Conclusion/interpretation. Positive family histories of Type II diabetes and hypertension are independent predictors of carotid intima-media thickness in patients with Type I diabetes, and could therefore predispose these patients to atherosclerosis [Diabetologia (2002) 45:711-718]

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Family histories of Type II diabetes and hypertension predict intima–media thickness in patients with Type I diabetes

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Details of the study design and recruitment have been reported elsewhere (15). Subjects were excluded from the study if they were known to have diabetes or were taking any medication that affects glucose tolerance or for infections, liver or kidney diseases, or thyroid function disorders.…”

Section: Methodsmentioning

confidence: 99%

Insulin Secretion and Insulin Sensitivity Pattern Is Different in Isolated Impaired Glucose Tolerance and Impaired Fasting Glucose

Hanefeld¹,

Koehler²,

et al. 2003

View full text Add to dashboard Cite

OBJECTIVE -Isolated impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are two risk categories for type 2 diabetes. This study compared both categories with respect to the degree of insulin secretion abnormalities and insulin resistance. RESEARCH DESIGN AND METHODS-This is a crossover comparison of a population at high risk for type 2 diabetes. The subjects were recruited from the Risk Factor in Impaired Glucose Tolerance for Atherosclerosis and Diabetes (RIAD) study. They underwent a 75-g oral glucose tolerance test, with measurement of specific insulin, C-peptide, proinsulin, and free fatty acids at baseline and every 30 min after load for 2 h. Factor analysis was performed to evaluate the importance of insulin resistance and secretion abnormalities in both categories.RESULTS -All categories of prediabetic hyperglycemia had a higher cardiovascular risk factor level when adjusted for sex, age, and BMI compared to control subjects with normal glucose tolerance. Subjects with isolated IFG were more insulin resistant than those with IGT. By contrast, subjects with isolated IGT exhibited a more severe deficit in early-and late-phase insulin secretion versus IFG subjects. As shown with factor analysis, in IFG the insulin resistance factor explained 28.4% of the variance, whereas in IGT the insulin secretion factor was dominant, explaining 31.1% of the total variance. CONCLUSIONS -Our cross-sectional data from the RIAD study demonstrate that isolated IFG and isolated IGT are different with respect to the degree of insulin resistance and anomalies in insulin secretion, and that subjects with IGT exhibit a deficit in the early and late phases of insulin secretion. This finding may be important for a differential approach in primary prevention of type 2 diabetes.

show abstract

“…1 Moreover, the association between UAE and increased CVD mortality in high-risk groups begins at levels of UAE below clinically defined thresholds for microalbuminuria. 1 Subclinical CVD, such as left ventricular (LV) hypertrophy 2-6 and increased carotid artery intima-media thickness (IMT), [7][8][9][10][11][12] has been associated with microalbuminuria among individuals at high risk for CVD. Whether the presence of increased UAE provides any additional predictive value for the presence of subclinical CVD in groups not at high risk aside from established, independent CVD risk factors remains unestablished.…”

mentioning

confidence: 99%

Urine Albumin Excretion and Subclinical Cardiovascular Disease

et al. 2005

View full text Add to dashboard Cite

Abstract-We examined the association between urine albumin excretion (UAE) and common and internal carotid artery intima-media thickness (IMT), end-diastolic left ventricular (LV) mass, and coronary artery calcification (CAC) scores using data from the Multi-Ethnic Study of Atherosclerosis (MESA), a population-based study of 6814 adults aged 45 to 85 years without clinical cardiovascular disease (CVD). The mean age of the MESA participants was 62.7 years, 47% were male, and 15% had diabetes mellitus (DM). Sex-specific spot urine albumin/creatinine ratios were used to define 4 UAE categories: normal, high normal, microalbuminuria, and macroalbuminuria. CAC scores were log-transformed after adding 1 to all scores. Key Words: cardiovascular diseases Ⅲ urine M icroalbuminuria, increased urine albumin excretion (UAE) below the detection of urinary dipstick measurement, strongly predicts cardiovascular disease (CVD) mortality in nondiabetic patients with established CVD. 1 Moreover, the association between UAE and increased CVD mortality in high-risk groups begins at levels of UAE below clinically defined thresholds for microalbuminuria. 1 Subclinical CVD, such as left ventricular (LV) hypertrophy 2-6 and increased carotid artery intima-media thickness (IMT), [7][8][9][10][11][12] has been associated with microalbuminuria among individuals at high risk for CVD. Whether the presence of increased UAE provides any additional predictive value for the presence of subclinical CVD in groups not at high risk aside from established, independent CVD risk factors remains unestablished. Coronary artery calcification (CAC) is highly correlated with the presence of coronary atherosclerotic plaque. [13][14][15] However, information on the association between CAC scores and UAE is currently limited.This study examined the association between UAE and several measures of subclinical CVD, including CAC scores, in a large multi-ethnic population without clinical CVD. We hypothesized that increased UAE is associated with subclinical CVD reflecting kidney damage caused by exposure to CVD risk factors, particularly diabetes mellitus (DM) and hypertension, and that these associations exist at UAE cutpoints below thresholds currently used to define microalbuminuria. An association between increased UAE and subclinical CVD in adults without clinical CVD may give further credence to using UAE to identify individuals who may benefit from aggressive risk factor intervention for the primary prevention of CV events.

show abstract

Relationship between fasting plasma glucose, atherosclerosis risk factors and carotid intima media thickness in non-diabetic individuals

Cited by 70 publications

References 27 publications

Family histories of Type II diabetes and hypertension predict intima–media thickness in patients with Type I diabetes

Family histories of Type II diabetes and hypertension predict intima–media thickness in patients with Type I diabetes

Insulin Secretion and Insulin Sensitivity Pattern Is Different in Isolated Impaired Glucose Tolerance and Impaired Fasting Glucose

Urine Albumin Excretion and Subclinical Cardiovascular Disease

Contact Info

Product

Resources

About