Relationship Between Family History of Breast Cancer and Health-Related Behavior

Ochoa, Eva Martínez; Gómez‐Acebo, Inés; Rodríguez-Cundín, Paz; Llorca, Javier; Dierssen-Sotos, Trinidad

doi:10.1080/08964289.2010.516783

Cited by 11 publications

(9 citation statements)

References 17 publications

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“…17,23 In our study, women with an FMH of breast or ovarian cancer had health behaviors similar to women without an FMH of cancer. Other studies have found similar results, 24,25 although some studies have found more intense or higher levels of physical activity in women with a family history of breast cancer, [26][27][28] or greater practice of health behaviors was observed, as compared with the general population. 26 In some of these studies, data were drawn on women of higher education or socioeconomic status; 26,28 therefore, these findings may not be generalizable to other populations, including ours.…”

Section: Discussionmentioning

confidence: 61%

“…Other studies have found similar results, 24,25 although some studies have found more intense or higher levels of physical activity in women with a family history of breast cancer, [26][27][28] or greater practice of health behaviors was observed, as compared with the general population. 26 In some of these studies, data were drawn on women of higher education or socioeconomic status; 26,28 therefore, these findings may not be generalizable to other populations, including ours. All health behavior models control for age, sex, race/ethnicity, household income, education, usual health-care provider, and marital status.…”

Section: Discussionmentioning

confidence: 61%

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Health behaviors and cancer screening among Californians with a family history of cancer

Townsend

Steele

Richardson

et al. 2013

Genetics in Medicine

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Purpose: The purpose of this study was to compare health behaviors and cancer screening among Californians with and without a family history of cancer. Methods:We analyzed data from the 2005 California Health Interview Survey to ascertain cancer screening test use and to estimate the prevalence of health behaviors that may reduce the risk of cancer. We used logistic regression to control for demographic factors and health-care access.results: Women with a family history of breast or ovarian cancer were more likely to be up to date with mammography as compared with women with no family history of cancer (odds ratio = 1.69, 95% confidence interval (1.39, 2.04)); their health behaviors were similar to other women. Men and women with a family history of colorectal cancer were more likely to be up to date with colorectal cancer screening as compared with individuals with no family history of cancer (odds ratio = 2.77, 95% confidence interval (2.20, 3.49)) but were less likely to have a body mass index <25 kg/m 2 (odds ratio = 0.80, 95% confidence interval (0.67, 0.94)).conclusion: Innovative methods are needed to encourage those with a moderate-to-strong familial risk for breast cancer and colorectal cancer to increase their physical activity levels, strive to maintain a healthy weight, quit smoking, and reduce alcohol use. 2013:15(3):212-221 Genet Med

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 61%

Health behaviors and cancer screening among Californians with a family history of cancer

Townsend

Steele

Richardson

et al. 2013

Genetics in Medicine

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show abstract

“…We excluded studies not conducted in the United States because important determinants of cancer screening such as healthcare coverage (8) vary by country. We excluded studies conducted in special populations (e.g., subjects with a family history of colon cancer) for which screening recommendations and practices may differ (9, 10) and thus, obscure the association between obesity and cancer screening. We did not require a specific measure of adiposity or study design.…”

Section: Methodsmentioning

confidence: 99%

Body Mass Index and Colon Cancer Screening: A Systematic Review and Meta-Analysis

Maruthur

Bolen

Gudzune

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Obesity is associated with increased colon cancer mortality and lower rates of mammography and Pap testing. Methods We conducted a systematic review to determine if obesity is associated with lower rates of colon cancer screening. We searched the PubMed, CINAHL, and Cochrane Library databases. Two investigators reviewed citations, abstracts, and articles independently. Two investigators abstracted study information sequentially and evaluated quality independently using standardized forms. We included all studies in our qualitative syntheses. We used random effects meta-analyses to combine those studies providing screening results by the following BMI categories: Normal, 18.5–24.9 kg/m2 (reference); overweight, 25–29.9 kg/m2; class I obesity, 30–34.9 kg/m2; class II obesity, 35–39.9 kg/m2; and class III obesity, ≥ 40 kg/ m2. Results Of 5,543 citations, we included 23 articles. Almost all studies were cross-sectional and ascertained BMI and screening through self report. BMI was not associated with colon cancer screening overall. The subgroup of obese white women reported lower rates of colon cancer screening compared to those with a normal BMI with combined odds ratios (95% CI) of 0.87 (0.82 to 0.93), 0.80 (0.65 to 0.99), and 0.73 (0.54 to 0.94) for class I, II, and III obesity, respectively. Results were similar among white men with class II obesity. Conclusions Overall, BMI was not associated with colon cancer screening. Obese white men and women may be less likely to undergo colon cancer screening compared to those with a normal BMI. Impact Further investigation of this disparity may reduce the risk of obesity-related colon cancer death.

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“…However, our understanding of the potential for risk reduction for the majority of modifiable of risk factors in this high risk group remains unknown. Studies investigating women with a strong family history of breast cancer have shown that these women are no more likely to engage in healthy lifestyle habits than women in the general population [31,32] making lifestyle interventions a potentially important target. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) is currently examining the role of various genetic modifiers of cancer risk in BRCA mutation carriers.…”

Section: Introductionmentioning

confidence: 99%

A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2gene carriers

et al. 2013

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BackgroundBreast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA genes, BRCA1 or BRCA2, the risk of developing breast or ovarian cancer is significantly increased. In recent years there has been increased penetrance of BRCA1 and BRCA2 associated breast cancer, prompting investigation into the role of modifiable risk factors in this group. Previous investigations into this topic have relied on participants recalling lifetime weight changes and subjective methods of recording physical activity. The influence of obesity-related biomarkers, which may explain the link between obesity, physical activity and breast cancer risk, has not been investigated prospectively in this group. This paper describes the design of a prospective cohort study investigating the role of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene mutation carriers.Methods/designParticipants will be recruited from breast cancer family risk clinics and genetics clinics. Lifestyle risk factors that will be investigated will include body composition, metabolic syndrome and its components, physical activity and dietary intake. PBMC telomere length will be measured as a potential predictor of breast cancer occurrence. Measurements will be completed on entry to the study and repeated at two years and five years. Participants will also be followed annually by questionnaire to track changes in risk factor status and to record cancer occurrence. Data will be analysed using multiple regression models. The study has an accrual target of 352 participants.DiscussionThe results from this study will provide valuable information regarding the role of modifiable lifestyle risk factors for breast cancer in women with a deleterious mutation in the BRCA gene. Additionally, the study will attempt to identify potential blood biomarkers which may be predictive of breast cancer occurrence.

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Relationship Between Family History of Breast Cancer and Health-Related Behavior

Cited by 11 publications

References 17 publications

Health behaviors and cancer screening among Californians with a family history of cancer

Health behaviors and cancer screening among Californians with a family history of cancer

Body Mass Index and Colon Cancer Screening: A Systematic Review and Meta-Analysis

A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2gene carriers

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